Nano-Enabled Sensors for High Performance in Detection and Monitoring

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Nanoelectronics, Nanosensors and Devices".

Deadline for manuscript submissions: 29 June 2024 | Viewed by 1358

Special Issue Editor


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Guest Editor
Materials Research and Technology (MRT), Luxembourg Institute of Science and Technology (LIST), 41, Rue du Brill, L-4408 Belvaux, Luxembourg
Interests: micro/nanofabrication; materials and interfaces; plasmon-enhanced spectroscopies, miniaturized sensing devices/kits
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Special Issue Information

Dear Colleagues,

Nanotechnologies have revolutionized the field of detection and monitoring, ushering in unprecedented opportunities to deliver high sensitivity within miniaturized footprints for a range of sectors, including healthcare, food, environment, security and outer space. Sensors have been sought to detect and monitor changes in concentrations of molecular analytes present in various scenarios, e.g., molecular biomarkers for healthcare diagnostics, gas compositions for air quality monitoring, toxins in quality control of food and beverages, and the detection of security threats from (bio)chemical terrorism markers. These situations may pose different sets of demands yet can benefit from the development of a common set of key enabling technologies. Nanotechnologies are especially interesting as they contribute to the development of such sensors at different levels, including as nanoscale transducers as a tool for signal enhancement, by bringing the appropriate choice of surface functionality, opportunities for miniaturization, and the means to fit to a desired form factor of choice by an end-user.

This Special Issue welcomes full papers, communications and reviews that push the boundaries of the state of the art in any of the following directions:

  • Fundamental investigation of nanostructure and interfacial properties that have potential to impact sensing performance in electrochemical, optical, mechanical or other transduction schemes;
  • Nanofabrication technologies in application to design, fabrication and application of nanoscale sensors;
  • Addressing challenges in the integration of nanostructures within nano-enabled sensing devices;
  • Assay schemes that enable continuous, real-time monitoring of molecular analytes;
  • Modelling and simulations enabling the rational design of nano-enabled sensors;
  • Novel approaches to multi-modal sensing;
  • Novel approaches to multi-analyte sensing;
  • Combination of sensors with artificial intelligence tools.

Accepted papers will be published in the joint Special Issue in Nanomaterials or Nanomanufacturing.

Dr. Sivashankar Krishnamoorthy
Guest Editor

Manuscript Submission Information

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Keywords

  • nanotechnologies
  • highly sensitive detection
  • continuous monitoring
  • healthcare diagnostics
  • molecular diagnostics
  • point-of-care sensors
  • environmental sensors
  • homeland security devices
  • food and beverage sensors
  • sensors for forensics
  • sensors for exploration of outer space

Published Papers (1 paper)

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Research

13 pages, 1087 KiB  
Article
Acid-Modulated Peptide Synthesis for Application on Oxide Biosensor Interfaces
by Edgar Cristóbal-Lecina, Janwa El-Maiss, Eduard Figueras, Aruna Chandra Singh, Sivashankar Krishnamoorthy, Thomas Østerbye, César Pascual García and David Andreu
Nanomaterials 2023, 13(24), 3092; https://doi.org/10.3390/nano13243092 - 6 Dec 2023
Viewed by 1108
Abstract
In this paper we report an acid-modulated strategy for novel peptide microarray production on biosensor interfaces. We initially selected a controlled pore glass (CPG) as a support for solid-phase peptide synthesis (SPPS) to implement a chemistry that can be performed at the interface [...] Read more.
In this paper we report an acid-modulated strategy for novel peptide microarray production on biosensor interfaces. We initially selected a controlled pore glass (CPG) as a support for solid-phase peptide synthesis (SPPS) to implement a chemistry that can be performed at the interface of multiple field effect transistor (FET) sensors, eventually to generate label-free peptide microarrays for protein screening. Our chemistry uses a temporary protection of the N-terminal amino function of each amino acid building block with a tert-butyloxycarbonyl (Boc) group that can be removed after each SPPS cycle, in combination with semi-permanent protection of the side chains of trifunctional amino acid residues. Such a protection scheme with a well-proven record of application in conventional, batchwise SPPS has been fine-tuned for optimal performance on CPG and, from there, translated to SPR chips that allow layer-by-layer monitoring of amino acid coupling. Our results validate this acid-modulated synthesis as a feasible approach for producing peptides in high yields and purity on flat glass surfaces, such as those in bio-FETs. Full article
(This article belongs to the Special Issue Nano-Enabled Sensors for High Performance in Detection and Monitoring)
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