The Effects of Diet and Exercise on Lipid Profiles in Young or Pre-clinical Populations

Dear Colleagues,

Overweight or obesity increase cardiovascular disease risk through factors such as increased fasting plasma triglycerides, high LDL cholesterol, low HDL cholesterol, elevated blood glucose and insulin levels, and high blood pressure. High dietary saturated fats have been thought to promote dyslipidemias and, consequently, atherogenesis. Conversely, the consumption of unsaturated fats, derived mostly from vegetable oils (e.g., safflower, corn, olive, and soybean), may help prevent serious disorders, including atherogenesis, hypertension, and metabolic syndrome.

Lifestyle changes (i.e., diet and exercise) are primarily advocated as a treatment for dyslipidemia. The chronic practice of exercise induces a series of cellular and organismal adaptations that modify the way the human body metabolizes all macronutrients, including lipids. Endurance exercise and resistance exercise elicit unique responses that result in differential effects on lipid and lipoprotein metabolism. These effects may be quantitatively and qualitatively different and mediated by distinct signaling pathways. Layered in these phenomena is an assumption that only those who are aged or presenting with disease are of concern for dyslipidemia. However, we might not yet fully appreciate the lipid profiles of those who are younger and how their profiles might be shaped by diet or exercise habits in a pre-clinical model. The study of those not yet clinically presenting is important for understanding their risk profile trajectory.

This Special Issue seeks submissions of manuscripts of original research or analytical reviews that explore the effects of acute or chronic exercise on dyslipidemia and nutrient metabolism.

Dr. Stephen Ives
Guest Editor

Dr. Christopher Kotarsky
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• dyslipidemia
• exercise
• nutrient metabolism
• metabolic syndrome
• obesity