Vitamin C: Challenges and Opportunities

Dear Colleagues,

Ascorbate is an indispensable nutrient known for its antioxidant properties and crucial role in diverse physiological processes, such as epigenetic regulation and immune function. Recent research and technological advancements have unveiled its critical function within the CNS, primarily through studies on the Sodium Vitamin C co-transporter 2 (SVCT2), the Vitamin C transporter present in the CNS. This Special Issue aims at exploring Vitamin C's multifaceted roles, bridging gaps between its biochemical pathways and its clinical implications for neurological health and disease.

I am pleased to invite you to highlight the importance of Vitamin C in neurobiology and pathophysiology, focusing on the challenges and opportunities for advancing understanding in areas such as neurodevelopment, mental health, cognitive function, aging, and neurodegenerative diseases. We encourage contributions that delve into the mechanistic actions of ascorbate in the CNS and explore translational research opportunities for novel therapeutic interventions.

In this Special Issue, we seek articles that cover a range of topics, including but not limited to the following:

• Mechanisms of Vitamin C transport and distribution within the brain and CNS cells;
• The role of Vitamin C in neurodevelopment and neuroplasticity;
• Epigenetic regulation by Vitamin C in neurological processes;
• Vitamin C's impact on neurodegenerative diseases;
• Clinical studies on Vitamin C supplementation in the context of neurological health and disease;
• Vitamin C and its relationship with cognitive functions and mental health;
• The role of Vitamin C in synaptic function and neurotransmitter regulation;
• Exploration of Vitamin C as a modulator of glial cell function and its implications for CNS health;
• Vitamin C in the context of brain injury and recovery: neuroprotective roles and therapeutic potential;
• Vitamin C's interaction with other nutrients and its impact on the CNS;
• Comparative studies on Vitamin C metabolism in various neurological conditions;
• Innovative methodologies for assessing Vitamin C's functions and mechanisms in the brain.

I eagerly anticipate your insightful contributions, which will enrich our collective understanding of Vitamin C's potential in neurobiology and clinical applications.

Dr. Camila C. Portugal
Guest Editor

Manuscript Submission Information

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• Vitamin C
• ascorbate
• antioxidant
• immune function
• cognitive function