Heterocyclic Compounds and Their Derivatives: Synthesis and Applications

A special issue of Organics (ISSN 2673-401X).

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 3492

Special Issue Editor

Department of Pharmaceutical Science, College of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, NE 68198-6125, USA
Interests: ketene; epoxide; diazocompound; cycloaddition reaction; cascade reaction; autocatalysis; asymmetric catalysis; anion-π cataylsis; supramolecular catalysis; ClpXP activators; neurolysin inhibitors

Special Issue Information

Dear Colleagues,

Heterocyclic molecues continue to exhibit new chemistries due to their unique reactivity and their central roles in biological chemistry. This Special Issue will cover the most recent discovers in the synthesis and applications of heterocyclic molecues utilizing different strategies and methodologies, as well as aspects of medicinal chemistry incorporating these heterocyclic compounds. It is devoted to presenting and disseminating the most recent developments in this area.

Dr. Xiaoyu Hao
Guest Editor

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Keywords

  • heterocyclic compounds
  • organic synthesis
  • natural products
  • ring cyclizations
  • ring openings
  • rearrangement
  • green chemistry
  • biological activity

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Published Papers (2 papers)

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Review

42 pages, 29305 KiB  
Review
Chiral Nonaromatic Nitrogen-Heterocycles by Asymmetric Intramolecular Haloamination and Haloamidation
by Mario Orena and Samuele Rinaldi
Organics 2024, 5(3), 163-204; https://doi.org/10.3390/org5030009 - 2 Jul 2024
Viewed by 601
Abstract
This review deals with the functionalization of double bonds carried out in the presence of a chiral catalyst exploiting the intramolecular attack to haliranium ions by nucleophilic nitrogen of amides or carbamates prepared from achiral aminoalkenes, and the C–N bonds formation leads to [...] Read more.
This review deals with the functionalization of double bonds carried out in the presence of a chiral catalyst exploiting the intramolecular attack to haliranium ions by nucleophilic nitrogen of amides or carbamates prepared from achiral aminoalkenes, and the C–N bonds formation leads to highly enantioenriched nonaromatic heterocycles. A range of protocols are reported, emphasizing the synthesis of many natural and biologically active products of pharmacological interest prepared according to this methodology. Full article
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21 pages, 4556 KiB  
Review
Synthesis of Antifungal Heterocycle-Containing Mannich Bases: A Comprehensive Review
by Diego Quiroga and Ericsson Coy-Barrera
Organics 2023, 4(4), 503-523; https://doi.org/10.3390/org4040035 - 9 Nov 2023
Cited by 3 | Viewed by 2228
Abstract
Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde. They are versatile intermediates in organic synthesis, and those compounds containing this motif find applications in pharmaceutical, agrochemical, [...] Read more.
Mannich bases are a class of organic compounds usually obtained by the condensation reaction between an amine, a compound with active hydrogens, and an aldehyde. They are versatile intermediates in organic synthesis, and those compounds containing this motif find applications in pharmaceutical, agrochemical, and even material fields since they are widely known for their wide range of biological activities, including antimicrobial properties. Thus, as part of our interest in antifungal agents, this narrative review aimed to gather information from the literature on the synthesis of various representative Mannich-base-containing compounds, particularly centered on those exhibiting antifungal properties. In this context, the compilation indicated that Mannich bases could be considered as a relevant toxophore/pharmacophore by incorporating heterocyclic moieties to be implemented for the design of new antifungal agents, given its proven efficacy against phytopathogens, other opportunistic human pathogens, and some dermatophytic fungal species, which can be further exploited as agrochemical agents or in medicinal applications to treat fungal infections. The antifungal effect exhibited by Mannich bases conjugated with oxa and/or aza-heterocycles suggests that compounds that have a heterocyclic system attached to the β-amino core are attractive alternatives oriented to the synthesis of novel and helpful antifungal agents. Full article
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