The Modern Trends in Organic Synthesis, including PASE and Green Chemistry

A special issue of Organics (ISSN 2673-401X).

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 4805

Special Issue Editors


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Guest Editor
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoy/Akademicheskaya, Ekaterinburg 620990, Russia
Interests: heterocyclic chemistry; fluorinated compounds; coordination compounds; building blocks; 1,2,4-triketones; furanones

E-Mail Website
Guest Editor
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoy/Akademicheskaya, Ekaterinburg 620990, Russia
Interests: heterocyclic chemistry; fluorinated compounds; coordination compounds; building blocks; 1,2,4-triketones; Schiff bases

Special Issue Information

Dear Colleagues,

The research focus of modern organic synthesis has been rapidly changing in recent years. Today, the integration of green chemistry principles and PASE (pot, atom, and step economy) approaches is a key trend in molecular design. In this context, the development of "building blocks" that enable the efficient synthesis of functionalized molecules is essential. Due to the combination of two or three reactive centers, the condensation of such systems can easily form both aliphatic and heterocyclic derivatives, including fluorinated derivatives. In terms of PASE, the desired formation of C-C, C-N, and C-O bonds proceeds under metal or metal-free C-H functionalization, organocatalysis, and electrochemical or photoredox reactions.

This Special Issue aims to familiarize readers with the most modern trends and achievements in the field of organic chemistry. We strongly encourage authors to submit original research articles, review papers, and short communications covering the last two decades of research innovations in organic synthesis. We especially welcome research describing the application of both metal catalysis and organocatalysis in the synthesis and functionalization of heterocyclic compounds for medicinal chemistry and the development of functional materials. We warmly invite studies concerning the development and application of polyfunctional molecules that represent convenient "building blocks" for the synthesis of various classes of organic substances.

Dr. Denis N. Bazhin
Dr. Yulia S. Kudyakova
Guest Editors

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Keywords

  • green chemistry
  • PASE
  • heterocyclic synthesis
  • building blocks
  • organocatalysis
  • Electrochemistry
  • photoredox reactions
  • C-H functionalization

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Published Papers (1 paper)

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Review

23 pages, 7756 KiB  
Review
4-Hydroxy-2-pyrones: Synthesis, Natural Products, and Application
by Vladislav V. Fedin, Dmitrii L. Obydennov, Sergei A. Usachev and Vyacheslav Y. Sosnovskikh
Organics 2023, 4(4), 539-561; https://doi.org/10.3390/org4040037 - 15 Dec 2023
Viewed by 3141
Abstract
4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in [...] Read more.
4-Hydroxy-2-pyrones are of interest as potential biorenewable molecules for a sustainable transition from biomass feedstock to valuable chemical products. This review focuses on the methodologies for the synthesis of 4-hydroxy-2-pyrones published over the last 20 years. These pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Biosynthetic paths of the pyrones are actively developed and used as biotechnological approaches for the construction of natural and unnatural polysubstituted 4-hydroxy-2-pyrones. The major synthetical methods are biomimetic and are based on the cyclization of tricarbonyl compounds. Novel chemical methods of de novo synthesis based on alkyne cyclizations using transition metal complexes and ketene transformations allow for straightforward access to 4-hydroxy-2-pyrones and have been applied for the construction of natural products. Possible directions for further pyrone ring modification are discussed. Full article
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