Current Research on Tuberculosis Prevention, Treatment, Care and Drugs

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Epidemiology of Infectious Diseases".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 4993

Special Issue Editors


E-Mail Website
Guest Editor
Clinic of Infectious Diseases, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, Bari, Italy
Interests: tuberculosis prevention; management of tuberculosis; tuberculosis in special population, TB-HIV confection; tropical medicine and emerging infectious diseases

E-Mail Website
Guest Editor
Clinic of Infectious Diseases, University of Bari, 70121 Bari, Italy
Interests: HIV; tuberculosis; NTM; malaria; antimicrobial resistance; HCV; HBV; SARS CoV2; COVID-19; infectious diseases
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Precision and Regenerative Medicine and Ionian Area-(DiMePRe-J), University of Bari “Aldo Moro”, Bari, Italy
Interests: emerging infectious diseases; antimicrobial resistance; antimicrobial stewardship; COVID-19; tuberculosis

Special Issue Information

Dear Colleagues,

Despite decades of work around the world to reduce its effects, TB remains an important global issue. In both high-burden and low-burden countries, the COVID-19 pandemic has affected the ways that TB and other infectious diseases (but also non-communicable diseases) are found, prevented, and treated. Without treatment, about half of the people with tuberculosis will die. However, with new drugs, especially for multidrug-resistant TB, about 85% of people can be cured.

Multisectoral efforts to address Tb risk factors, such as poverty, undernourishment, HIV infection, smoking, diabetes, and lack of access to health care, can reduce the number of people who become infected and ill, and therefore the number of people who die from tuberculosis.

In this ongoing context, current research on its prevention, treatment, and care is crucial to reducing the TB burden and improving the outcomes of patients, and it is also crucial to share this research with your worldwide colleagues.

For this Special Issue, manuscripts that cover all areas of TB prevention, diagnosis, management, and therapy are encouraged. We are interested in either reviews (literature reviews or systematic reviews), prospective or retrospective studies, or case studies.

Manuscripts that address the following topics are also welcome:

  1. Mycobacterium tuberculosis surveillance and pathogenesis;
  2. Experience with MDR-TB treatment;
  3. Risk factors for tuberculosis and latent TB infection (LTBI);
  4. Non-tuberculous mycobacteria (NTM);
  5. Vulnerable populations (migrants, homeless people);
  6. Epidemiology of tuberculosis;
  7. Tuberculosis in immunocompetent and immunocompromised people;
  8. Both communicable diseases and non-communicable diseases related to TB presentation and outcome.

Dr. Giuseppina De Iaco
Prof. Dr. Francesco Di Gennaro
Dr. Francesco Vladimiro Segala
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tuberculosis
  • epidemiology
  • multidrug-resistant TB
  • non-tuberculous mycobacteria
  • Mycobacterium tuberculosis

Published Papers (3 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Review

Jump to: Other

23 pages, 1216 KiB  
Review
The Role of Next-Generation Sequencing (NGS) in the Management of Tuberculosis: Practical Review for Implementation in Routine
by Marion Beviere, Sophie Reissier, Malo Penven, Loren Dejoies, François Guerin, Vincent Cattoir and Caroline Piau
Pathogens 2023, 12(8), 978; https://doi.org/10.3390/pathogens12080978 - 26 Jul 2023
Cited by 2 | Viewed by 2798
Abstract
Next-generation sequencing (NGS) has modernized the field of tuberculosis (TB) research by enabling high-throughput sequencing of the entire genome of Mycobacterium tuberculosis (MTB), which is the causative agent of TB. NGS has provided insights into the genetic diversity of MTB, which are crucial [...] Read more.
Next-generation sequencing (NGS) has modernized the field of tuberculosis (TB) research by enabling high-throughput sequencing of the entire genome of Mycobacterium tuberculosis (MTB), which is the causative agent of TB. NGS has provided insights into the genetic diversity of MTB, which are crucial for understanding the evolution and transmission of the disease, and it has facilitated the identification of drug-resistant strains, enabling rapid and accurate tailoring of treatment. However, the high cost and the technical complexities of NGS currently limit its widespread use in clinical settings. International recommendations are thus necessary to facilitate the interpretation of polymorphisms, and an experimental approach is still necessary to correlate them to phenotypic data. This review aims to present a comparative, step-by-step, and up-to-date review of the techniques available for the implementation of this approach in routine laboratory workflow. Ongoing research on NGS for TB holds promise for improving our understanding of the disease and for developing more efficacious treatments. Full article
Show Figures

Figure 1

Other

Jump to: Review

6 pages, 1256 KiB  
Case Report
Successful Management, in a Low-Resource Setting, of Disseminated Tuberculosis in a 3-Year Old Boy: A Case Report
by Josina Chilundo, Arlindo Muhelo, Zita Ahivaldino, Helton Zucula, Sheila Macuácua, Ana Cristina Mussagi, Damiano Pizzol, Lee Smith and Giuseppe Maggioni
Pathogens 2023, 12(9), 1163; https://doi.org/10.3390/pathogens12091163 - 15 Sep 2023
Viewed by 796
Abstract
Disseminated or military tuberculosis (TB) is defined as the presence of at least two non-contiguous sites of Mycobacterium tuberculosis, occurring as a result of progressive primary infection, reactivation and spread of a latent focus or due to iatrogenic origin. Disseminated TB represents [...] Read more.
Disseminated or military tuberculosis (TB) is defined as the presence of at least two non-contiguous sites of Mycobacterium tuberculosis, occurring as a result of progressive primary infection, reactivation and spread of a latent focus or due to iatrogenic origin. Disseminated TB represents a life-threatening condition, especially in at-risk children and when diagnosis and treatment are delayed. We report on a case of a 3-year old boy who presented with long-lasting unrecognised disseminated TB that was successfully managed in a low-resource setting. Full article
Show Figures

Figure 1

12 pages, 1017 KiB  
Systematic Review
Isoniazid and Rifampicin Resistance-Conferring Mutations in Mycobacterium tuberculosis Isolates from South Africa
by Afsatou Ndama Traoré, Mpumelelo Casper Rikhotso, Marry Avheani Mphaphuli, Sana Mustakahmed Patel, Hafsa Ali Mahamud, Leonard Owino Kachienga, Jean-Pierre Kabue and Natasha Potgieter
Pathogens 2023, 12(8), 1015; https://doi.org/10.3390/pathogens12081015 - 04 Aug 2023
Viewed by 1025
Abstract
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), remains a significant global health issue, with high morbidity and mortality rates. The emergence of drug-resistant strains, particularly multidrug-resistant TB (MDR-TB), poses difficult challenges to TB control efforts. This comprehensive review and meta-analysis [...] Read more.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), remains a significant global health issue, with high morbidity and mortality rates. The emergence of drug-resistant strains, particularly multidrug-resistant TB (MDR-TB), poses difficult challenges to TB control efforts. This comprehensive review and meta-analysis investigated the prevalence of and molecular insights into isoniazid (INH) and rifampicin (RIF) resistance-conferring mutations in M. tb isolates from South Africa. Through systematic search and analysis of 11 relevant studies, we determined the prevalence of gene mutations associated with RIF and INH resistance, such as rpoB, katG, and inhA. The findings demonstrated a high prevalence of specific mutations, including S450L in rpoB, and S315T, which are linked to resistance against RIF and INH, respectively. These results contribute to the understanding of drug resistance mechanisms and provide valuable insights for the development of targeted interventions against drug-resistant TB. Full article
Show Figures

Figure 1

Back to TopTop