Proteomics of Host-Helminth Interactions
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 30630
Special Issue Editors
Interests: molecular biology of trematode parasites and their host interactions
Interests: interrogation of omics datasets to investigate drug resistance, parasite development and host-parasite interaction to discover novel targets for vaccines and diagnostics
Special Issue Information
Dear Colleagues,
Helminth parasites remain a significant global human and animal health concern. The continued spread of drug resistance means that many parasite populations are difficult to manage and this has hastened the search for novel vaccine candidates and targets for improved diagnostic tests. Proteins secreted by helminths, or displayed on their outer surface, perform key roles in the host-parasite interaction and are thus leading candidates for these applications. In the past, profiling these was a major challenge due to the relative intractability of most species to conventional culture techniques and because of the low abundance/transient expression of the molecules themselves. However, the application and development of mass-spectrometry-based proteomics techniques has revolutionized our ability to identify helminth proteins, to study their modifications, and to profile changes in their expression during parasite growth and development. More recently, proteomics tools have been effectively used to investigate the interaction of helminth-derived molecules with host cells and to examine their effects on the host’s proteome.
In this Special Issue, we aim to highlight recent advances in the field, covering the interaction of helminth parasites with their hosts from both perspectives. By doing so, we hope to consolidate these developments and stimulate further discussion on the use of proteomics as a tool for investigating helminth-host interactions in the future.
Both original research and review articles are welcome.
Dr. Mark Robinson
Dr. Krystyna Cwiklinski
Guest Editors
Manuscript Submission Information
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Keywords
- helminth
- proteomics
- host-parasite interactions
- secretome
- interactome