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Pathogens
Special Issues
Mechanisms of Pathogenicity in Respiratory Bacterial Infections of Livestock
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Mechanisms of Pathogenicity in Respiratory Bacterial Infections of Livestock

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 15 May 2024 | Viewed by 1129

Special Issue Editors

Prof. Dr. Peter Valentin-Weigand

E-Mail Website
Guest Editor
Department of Infectious Diseases, Institute for Microbiology, University of Veterinary Medicine Hannover, 30173 Hannover, Germany
Interests: host-pathogen interactions in streptococcal infections; mono- and co-infections in the porcine respiratory tract
Special Issues, Collections and Topics in MDPI journals
Dr. Désirée Schaaf

E-Mail Website
Guest Editor
Institute for Microbiology, University of Veterinary Medicine Hannover, 30173 Hannover, Germany
Interests: mono- and co-infections in the porcine respiratory tract; host-pathogen interactions; bacterial toxins

Special Issue Information

Dear Colleagues,

Respiratory infections in livestock represent a serious health issue and cause major economic losses for the animal industry. Though viruses are responsible for the majority of respiratory diseases, several threatening infections are caused by bacterial pathogens. However, respiratory infections are the result of complex interactions between several factors – primary pathogens that pave the way for secondary infection with other pathogens as well as environmental factors and the host’s immune status.

This Special Issue focuses on host–bacterial as well as pathogen-pathogen interactions in the respiratory tract of livestock in order to improve the understanding of the pathomechanisms of respiratory bacterial infections, which is fundamental for the development of new therapeutic and preventive approaches.

We will consider for publication original scientific research articles and comprehensive reviews that address current challenges and advance the field.

Prof. Dr. Peter Valentin-Weigand
Dr. Désirée Schaaf
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • host-pathogen interactions
  • bacterial infections of livestock
  • pathomechanisms of bacterial infections
  • respiratory bacterial infections
  • livestock

Published Papers (1 paper)

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Research

15 pages, 1931 KiB  
Article
Transcriptional Host Responses to Infection with Streptococcus suis in a Porcine Precision-Cut Lung Slice Model: Between-Strain Differences Suggest Association with Virulence Potential
by Yenehiwot Berhanu Weldearegay, Louise Brogaard, Andreas Nerlich, Désirée Schaaf, Peter M. H. Heegaard and Peter Valentin-Weigand
Pathogens 2024, 13(1), 4; https://doi.org/10.3390/pathogens13010004 (registering DOI) - 19 Dec 2023
Viewed by 963
Abstract
Streptococcus suis is a porcine and zoonotic pathogen in the upper respiratory tract, expressing different capsular serotypes and virulence-associated factors. Given its genomic and phenotypic diversity, the virulence potential of S. suis cannot be attributed to a single factor. Since strong inflammatory response [...] Read more.
Streptococcus suis is a porcine and zoonotic pathogen in the upper respiratory tract, expressing different capsular serotypes and virulence-associated factors. Given its genomic and phenotypic diversity, the virulence potential of S. suis cannot be attributed to a single factor. Since strong inflammatory response is a hallmark of S. suis infection, the objective of this study was to investigate the differences in transcriptional host responses to two serotype 2 and one serotype 9 strains. Both serotypes are frequently found in clinical isolates. We infected porcine precision-cut lung slices (PCLSs) with two serotype 2 strains of high (strain S10) and low (strain T15) virulence, and a serotype 9 strain 8067 of moderate virulence. We observed higher expression of inflammation-related genes during early infection with strains T15 and 8067, in contrast to infection with strain 10, whose expression peaked late. In addition, bacterial gene expression from infected PCLSs revealed differences, mainly of metabolism-related and certain virulence-associated bacterial genes amongst these strains. We conclude that the strain- and time-dependent induction of genes involved in innate immune response might reflect clinical outcomes of infection in vivo, implying rapid control of infection with less virulent strains compared to the highly virulent strain S10. Full article
(This article belongs to the Special Issue Mechanisms of Pathogenicity in Respiratory Bacterial Infections of Livestock)
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