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Characteristics, Identification and Epidemiology of Respiratory Pathogens Associated with Airway Diseases

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Special Issue Editors

Dr. Katalin Burián

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Guest Editor

1. Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
2. Department of Clinical Microbiology, University of Szeged, Szeged, Hungary
Interests: chlamydia; cytokines; pathogenesis; animal model; epidemiology

Dr. Dóra Paróczai

E-Mail Website
Guest Editor

1. Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary
2. Department of Pulmonology, University of Szeged, Szeged, Hungary
Interests: chlamydia; cytokines; pathogenesis; animal model; epidemiology

Special Issue Information

Dear Colleagues,

There is accumulating evidence that bacterial, viral, or fungal microbiota in the lungs predict the susceptibility of further airway infections, such as pneumonia, and contribute to the severity of different respiratory diseases. Respiratory infections could determine and worsen the outcomes of chronic obstructive pulmonary diseases (COPD) or asthma; however, there are many queries yet to be answered. In addition to widespread bacterial or viral microorganisms, there are far more pathogens with clinical relevance implicated in these diseases, but their role is not yet fully elucidated.

The aim of this Special Issue is to reveal the epidemiology of pathogens associated with respiratory diseases and to unravel potential mechanisms leading to disease severity. The scope will cover a range of bacterial, viral, or fungal infections; however, preference will be given to intracellular bacteria and fungi. We invite you to submit either original research articles in terms of epidemiological studies or even basic research projects with cell or animal models; reviews related to the imbalance of the lung microbiome, characterization, identification of microorganisms, and immune response to the pathogens that are associated with airway diseases are also welcome.

We look forward to receiving your contributions to this Special Issue. Please feel free to invite your young ambitious colleagues to submit either original research or review articles.

Dr. Katalin Burián
Dr. Dóra Paróczai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

chlamydia
cytokines
pathogenesis
epidemiology
respiratory infections
asthma

Published Papers (2 papers)

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Research

Jump to: Review

18 pages, 686 KiB

Open AccessArticle

Change for the Better: Severe Pneumonia at the Emergency Department

by Dariusz Kawecki, Anna Majewska and Jarosław Czerwinski

Pathogens 2022, 11(7), 779; https://doi.org/10.3390/pathogens11070779 - 8 Jul 2022

Cited by 1 | Viewed by 1635

Abstract

This is a single-centre observational study of adult patients with severe pneumonia requiring hospitalization conducted at the emergency department. During the observation period (94 weeks), 398 patients were diagnosed with severe pneumonia and required further treatment at the hospital. The median age of patients was 73 years. About 65% of patients had at least one chronic comorbidity. Almost 30% of patients had cardiovascular disorders, and 13% had diabetes mellitus. The average Emergency Department length of stay was 3.56 days. The average length of hospitalization was 15.8 days. Overall, 94% of patients treated for pneumonia received a beta-lactam antibiotic. The median time from ED admission to the administration of the first dose of antimicrobial agent was less than 6 h. Microbiology test samples were obtained from 48.7% patients. Gram-positive cocci were isolated most commonly (52.9%) from blood samples. Biological material from the lower respiratory tract was collected from 8.3% of patients, and from 47.2% of positive samples, fungi were cultured. The urine samples were obtained from 35.9% patients, and Gram-negative rods (76%) were isolated most commonly. Overall, 16.1% of patients died during the hospitalization. The mean age of patients who died was 79 years. This observational study is the first single-centre study conducted as part of the Polish Emergency Department Research Organization (PEDRO) project. It aims to provide up-to-date information about patients with pneumonia in order to improve medical care and develop local diagnostic and therapeutic recommendations. Full article

(This article belongs to the Special Issue Characteristics, Identification and Epidemiology of Respiratory Pathogens Associated with Airway Diseases)

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Review

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15 pages, 1049 KiB

Open AccessReview

The Microbiome as Part of the Contemporary View of Tuberculosis Disease

by Martín Barbosa-Amezcua, David Galeana-Cadena, Néstor Alvarado-Peña and Eugenia Silva-Herzog

Pathogens 2022, 11(5), 584; https://doi.org/10.3390/pathogens11050584 - 16 May 2022

Cited by 5 | Viewed by 2651

Abstract

The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest human diseases, it is primarily a respiratory infectious disease caused by strains from the Mycobacterium tuberculosis Complex. Even today, during the COVID-19 pandemic, it remains one of the principal causes of morbidity and mortality worldwide. Tuberculosis disease manifests itself as a dynamic spectrum that ranges from asymptomatic latent infection to life-threatening active disease. The review aims to provide an overview of the microbiome in the tuberculosis setting, both in patients’ and animal models. We discuss the relevance of the microbiome and its dysbiosis, and how, probably through its interaction with the immune system, it is a significant factor in tuberculosis’s susceptibility, establishment, and severity. Full article

(This article belongs to the Special Issue Characteristics, Identification and Epidemiology of Respiratory Pathogens Associated with Airway Diseases)

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