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Pharmaceuticals
Special Issues
Nano-Strategies in Fighting Cancer
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Nano-Strategies in Fighting Cancer

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1664

Special Issue Editors

Dr. Ahmad Sohrabi Kashani

E-Mail Website
Guest Editor
National Research Concuil of Canada, Montreal, QC, Canada
Interests: nanomedicines; cancer; cell mechanics; mechanobiology; biosensor; microfluidic; biomaterials; POC diagnostic devices; intracellular plasmonic
Prof. Dr. Muthukumaran Packirisamy

E-Mail Website
Guest Editor
Department of Mechanical Engineering, Concordia University, Montréal, QC H3G2W1, Canada
Interests: nano-bio interactions; biosensors; optical BIoMEMS
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

Despite numerous technological advancements in cancer detection and treatment, global cancer management still encounters challenges in achieving efficiency. Over the past two decades, the field of nanotechnology has facilitated the emergence of the nano-bio interaction domain, enhancing our understanding of how nano-sized particles interact with the biological environment. While significant progress has been made in developing more efficient treatment approaches for enhanced cancer management within this field, many aspects remain understudied. For instance, although the biophysical properties of cells, such as cell mechanics, have been extensively examined for their roles in cancer progression and metastasis, their relevance in the context of nano-bio interaction and the development of nanotools for cancer management have not been thoroughly investigated. Due to the small size of nanoparticles, they have the potential to interact with cytoskeleton components, thereby impacting cell functionality by altering mechanobiological responses. In this sense, the physicochemical properties of nanoparticles can be modified to potentially target cell mechanobiology, in addition to their other intended therapeutic purposes, for increased effectiveness. This precision allows for the control of critical functions, including migration, adhesion, and invasion, which are the key drivers of metastasis.

This Special Issue serves as a platform to showcase research papers and reviews that highlight recent developments in using nanoparticles to enhance cancer management. For instance, this includes targeting the biophysical properties of cancer cells for more effective treatment or improving cancer diagnosis through the development of sensitive and innovative methods. Through this multidisciplinary exploration, our aim is to advance our understanding of how nanoparticles can revolutionize cancer management and identify future directions that will lead to innovative solutions for persistent challenges in cancer management.

Dr. Ahmad Sohrabi Kashani
Prof. Dr. Muthukumaran Packirisamy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomedicines
  • targeted therapy
  • intracellular diagnosis
  • cell mechanics
  • nano-biosensor
  • nano-bio interaction
  • mechanobiology
  • nano-biomechanics
  • drug delivery
  • migration

Published Papers (1 paper)

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Research

19 pages, 5449 KiB  
Article
In Silico, In Vitro, and In Vivo Evaluation of Caffeine-Coated Nanoparticles as a Promising Therapeutic Avenue for AML through NF-Kappa B and TRAIL Pathways Modulation
by Muhammad Hamid Siddique, Sidra Bukhari, Inam Ullah Khan, Asiya Essa, Zain Ali, Usama Sabir, Omiya Ayoub, Haleema Saadia, Muhammad Yaseen, Aneesa Sultan, Iram Murtaza, Philip G. Kerr, Mashooq Ahmad Bhat and Mariam Anees
Pharmaceuticals 2023, 16(12), 1742; https://doi.org/10.3390/ph16121742 - 18 Dec 2023
Cited by 1 | Viewed by 1338
Abstract
Background: Advancements in nanoscience have led to a profound paradigm shift in the therapeutic applications of medicinally important natural drugs. The goal of this research is to develop a nano-natural product for efficient cancer treatment. Methods and Results: For this purpose, mesoporous silica [...] Read more.
Background: Advancements in nanoscience have led to a profound paradigm shift in the therapeutic applications of medicinally important natural drugs. The goal of this research is to develop a nano-natural product for efficient cancer treatment. Methods and Results: For this purpose, mesoporous silica nanoparticles (MSNPs) were formulated, characterized, and loaded with caffeine to develop a targeted drug delivery system, i.e., caffeine-coated nanoparticles (CcNPs). In silico docking studies were conducted to examine the binding efficiency of the CcNPs with different apoptotic targets followed by in vitro and in vivo bioassays in respective animal models. Caffeine, administered both as a free drug and in nanomedicine form, along with doxorubicin, was delivered intravenously to a benzene-induced AML model. The anti-leukemic potential was assessed through hematological profiling, enzymatic biomarker analysis, and RT-PCR examination of genetic alterations in leukemia markers. Docking studies show strong inter-molecular interactions between CcNPs and apoptotic markers. In vitro analysis exhibits statistically significant antioxidant activity, whereas in vivo analysis exhibits normalization of the genetic expression of leukemia biomarkers STMN1 and S1009A, accompanied by the restoration of the hematological and morphological traits of leukemic blood cells in nanomedicine-treated rats. Likewise, a substantial improvement in hepatic and renal biomarkers is also observed. In addition to these findings, the nanomedicine successfully normalizes the elevated expression of GAPDH and mTOR induced by exposure to benzene. Further, the nanomedicine downregulates pro-survival components of the NF-kappa B pathway and upregulated P53 expression. Additionally, in the TRAIL pathway, it enhances the expression of pro-apoptotic players TRAIL and DR5 and downregulates the anti-apoptotic protein cFLIP. Conclusions: Our data suggest that MSNPs loaded with caffeine, i.e., CcNP/nanomedicine, can potentially inhibit transformed cell proliferation and induce pro-apoptotic TRAIL machinery to counter benzene-induced leukemia. These results render our nanomedicine as a potentially excellent therapeutic agent against AML. Full article
(This article belongs to the Special Issue Nano-Strategies in Fighting Cancer)
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