Advances in Mass Spectrometry Metrology in Pharmaceutical Sciences

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 976

Special Issue Editors


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Guest Editor
AbbVie, Inc., 1 Waukegan Rd, North Chicago, IL 60064, USA
Interests: quantitation; sensitivity; imaging

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Guest Editor
Division of Imaging Mass Spectrometry, Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht University, Maastricht, The Netherlands
Interests: mass spectrometry (imaging); analytical method development; quantitation

Special Issue Information

Dear Colleagues, 

Mass spectrometry metrology is a critical aspect of the pharmaceutical industry as it enables the precise and accurate measurement of drug compounds, metabolites, and impurities. This technology plays a vital role in drug discovery, pharmacokinetics, and clinical research, making it an essential tool for pharmaceutical scientists. 

The Special Issue of Pharmaceuticals aims to showcase the latest developments in mass spectrometry metrology, including new techniques, instrumentation, and data analysis methods. This Special Issue will feature research articles, reviews, and communications that highlight the advancements and applications of mass spectrometry in pharmaceutical sciences. 

We invite you to submit original research and review articles addressing advances in mass spectrometry metrology in its application to the pharmaceutical industry to be published in this Special Issue of Pharmaceuticals. Proposed topics related to the general theme include, but are not limited to, improved techniques for sensitivity, new datamining algorithms to search for metabolites, new technologies for the ionization of pharmaceuticals, and trace analysis of pharmaceuticals in un-dosed populations. 

Yours sincerely,

Dr. Andrew P. Bowman
Prof. Rob J. Vreeken
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • analytical standards
  • calibration
  • quality control
  • reference materials
  • validation
  • impurities
  • stability
  • traceability
  • analytical methods
  • drug analysis

Published Papers (1 paper)

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Research

12 pages, 543 KiB  
Article
An Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometric Method for the Simultaneous Determination of Eighteen Marker Compounds in the Traditional Herbal Formula Bopyeo-Tang
by Chang-Seob Seo
Pharmaceuticals 2024, 17(3), 352; https://doi.org/10.3390/ph17030352 - 8 Mar 2024
Viewed by 693
Abstract
Bopyeo-tang (BPT), comprising six medicinal plants, has been used for the treatment of respiratory diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease. In this study, we developed and validated a quantitative method for the quality assessment of BPT using ultra-performance liquid [...] Read more.
Bopyeo-tang (BPT), comprising six medicinal plants, has been used for the treatment of respiratory diseases such as pulmonary fibrosis and chronic obstructive pulmonary disease. In this study, we developed and validated a quantitative method for the quality assessment of BPT using ultra-performance liquid chromatography with tandem mass spectrometry (UPLC–MS/MS). Eighteen marker compounds were separated on an Acquity UPLC BEH C18 reversed-phase column (2.1 mm × 100 mm, 1.7 μm) via gradient elution with a 0.1% aqueous formic acid–acetonitrile mobile phase. The multiple-reaction monitoring mode was used to improve analysis speed and accuracy. The coefficients of determination, limits of detection, and limits of quantitation of the 18 marker compounds were 0.9991–0.9996, 0.36–24.45 μg/L, and 1.07–73.35 μg/L, respectively. The recovery was 85.19–110.25%, and the relative standard deviation of precision was ≤9.01%. When applied to a typical BPT sample, the method revealed a range of concentrations from below the quantitative limit (one compound only) to a maximum of 3.20 mg/freeze-dried g. This method will be used for quality control of BPT preparations. Full article
(This article belongs to the Special Issue Advances in Mass Spectrometry Metrology in Pharmaceutical Sciences)
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