Drug Candidates for Allergic Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 14963
Special Issue Editor
Special Issue Information
Dear Colleagues,
Over the last two decades, novel drugs have emerged, paving the way for the personalized management of allergic diseases. Bronchoscopy studies and mouse models of asthma have provided initial insights into the mechanisms of allergic inflammation establishing, the role of Th2 type 2 cytokines including IL-4 and IL-5 IL-13 that led to the development of several monoclonal antibodies (mAbs) targeting these cytokines. Omalizumab was the first mAb used successfully to treat severe asthma patients. Subsequently, other drugs emerged, including antibodies that block IL-5 (mepolizumab, reslizumab) and the IL-5 receptor (benralizumab), the IL-4/IL-13 receptor alpha chain (dupilumab), and the thymic stromal lymphopoietin (Tezepelumab). These novel biologicals have been shown to be good alternative therapies to corticosteroids, particularly in severe asthma management, where they have improved the quality of life of many patients. Given the success in asthma, these drugs have been used in other allergic diseases, including chronic rhinosinusitis with nasal polyps (CRSwNP), atopic dermatitis, eosinophilic esophagitis, and chronic urticaria. Currently, a number of novel antagonists targeting other inflammatory mediators are still in preclinical stages.
This Special Edition will assemble a series of articles that examine the effects of novel drugs in allergic diseases.
Prof. Dr. Luis Manuel Teran
Guest Editor
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Keywords
- allergic disease
- asthma
- CRSwNP
- atopic dermatitis
- biologicals
- chronic urticaria
- pharmacology
- novel drugs
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