Dear Colleagues,

Improving the bioavailability of drugs is a critical aspect of pharmaceutical development, as it can lead to better therapeutic outcomes and reduced dosages, thereby minimizing side effects. Bioavailability refers to the proportion of the administered dose of a drug that reaches the systemic circulation and is available to exert its pharmacological effects. This Anniversary Special Issue for the topic “Improvement of bioavailability” will collect some strategies that pharmaceutical researchers and scientists employ to enhance the bioavailability of drugs: formulation optimization, prodrug design, nanotechnology, use of excipients, amorphous solid dispersions, pH adjustment, salt formation, particle size reduction, enhanced permeability, inclusion complexes, co-crystals, modified release formulations, targeted drug delivery.

Due to their inherent and unique physico-chemical characteristics (crystallinity, solubility, stability), each drug, and the appropriate strategy to improve its bioavailability, will depend on its specific characteristics and challenges, such as the administration route. Indeed, pharmaceutical scientists often conduct thorough studies and optimization to select the most effective approach for each particular drug. These strategies will also consider the poor water-soluble characteristics of the drugs to enable adequate bioavailability after administration. This solubility problem greatly hinders pharmaceutical development and ultimately prevents patients from accessing potentially life-saving treatments.

I look forward to receiving your contributions.

Prof. Dr. Thierry Vandamme
Guest Editor

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• bioavailability
• in vivo formulation optimization
• improvement pharmacokinetics
• biopharmacy
• decrease side effects
• poor water solubility
• oral route
• parenteral route
• topical administration
• preformulation
• preclinical formulation