Polymer-Based Coatings in Prosthetics Research

A special issue of Prosthesis (ISSN 2673-1592).

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1263

Special Issue Editors


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Guest Editor
Department of Health Science and Technology, Aalborg University, DK-9220 Aalborg, Denmark
Interests: regenerative medicine; stem cell culture; tissue engineering; biomaterials; mechanobiology; stem cell differentiation; biocompatibility

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Guest Editor
Polymer Chemistry & Biomaterials Research Group, Centre of Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4 Bis, 9000 Ghent, Belgium
Interests: hydrogels; 3D printing; electrospinning; two-photon polymerization; proteins; polysaccharides; tissue engineering; hydrogel functionalization
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Special Issue Information

Dear Colleagues, 

This Special Issue is devoted to the development and application of polymer-based coatings in the field of prosthetics. The ability of an implantable prosthesis to integrate into the host and perform its intended function is largely determined by the interface between the biomaterial and the biological environment. Therefore, it is critical to understand the interactions between cells and surfaces, and to develop approaches to control surface properties such as wettability, chemistry, topography, and electrical conductivity while maintaining the bulk implant properties. In particular, polymers enable the development of biomimetic and bioactive coatings that have shown promise for influencing the biological response of implantable medical prostheses. In orthopedic implants, for example, polymeric coatings have proven to be optimal systems for encapsulating drugs that can be released locally at the implant–tissue interface, facilitating tissue integration and reducing foreign body response. Another successful example is antibacterial coatings, which have proven useful in preventing implant-related infections. More recently, progress has been made in the development of hydrogel-based coatings. These not only replicate the natural microenvironment of cells, but also exhibit many other desirable properties, such as biocompatibility, biodegradability, easily tunable mechanical properties, and the ability to encapsulate biological agents.

The aim of this Special Issue is to collect recent studies that could make an important contribution to progress in polymer-based coatings for implantable medical prostheses. The scope includes both theoretical and experimental research, from studies looking to improve the surface properties of medical implants to novel manufacturing technologies, characterization methods, and applications.

Potential topics for original research articles and critical reviews include the following:

  • Polymer-based coatings
  • Polymer-based composites
  • Biodegradable coatings
  • Smart implants
  • Drug-releasing coatings
  • Coatings to mitigate foreign body reaction
  • Antibacterial hydrogel coatings
  • Antithrombogenic coatings
  • Approaches to improve the resistance to insertion forces
  • Conductive polymers for neural prosthetic devices
  • 3D printing of hydrogels for use in prosthetic devices

Dr. Pablo Pennisi
Prof. Dr. Sandra Van Vlierberghe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Prosthesis is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer coatings
  • conducting polymer
  • antifouling coatings
  • antibacterial coatings
  • stents
  • vascular prosthesis
  • orthopaedic prosthesis
  • neural prosthesis
  • antithrombogenic coatings
  • foreign body reaction

Published Papers (1 paper)

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Research

11 pages, 6751 KiB  
Article
Development of Small-Diameter Artificial Vascular Grafts Using Transgenic Silk Fibroin
by Takashi Tanaka, Sakiko Hara, Hanan Hendawy, Hussein M. El-Husseiny, Ryo Tanaka and Tetsuo Asakura
Prosthesis 2023, 5(3), 763-773; https://doi.org/10.3390/prosthesis5030054 - 12 Aug 2023
Cited by 7 | Viewed by 1208
Abstract
Silk fibroin (SF) is a suitable material for vascular prostheses for small arteries. SF is useful not only as a base material for artificial vascular grafts but also as a coating material. This study prepared three types of transgenic SF (vascular endothelial growth [...] Read more.
Silk fibroin (SF) is a suitable material for vascular prostheses for small arteries. SF is useful not only as a base material for artificial vascular grafts but also as a coating material. This study prepared three types of transgenic SF (vascular endothelial growth factor (VEGF), Arg-Glu-Asp-Val (REDV), and Tyr-Ile-Gly-Ser-Arg (YIGSR)) incorporating expression factors that are thought to be effective for endothelialization as coating materials. We compared the contribution of these materials to early endothelialization in vivo when using them as a porous transgenic SF coating. A porous coating of transgenic SF containing VEGF, REDV, and YIGSR was applied to a silk small-diameter artificial vascular graft base with a diameter of 1.5 mm and a length of 3 cm. Two and four weeks after implantation of these artificial grafts into the abdominal aorta of rats, they were removed and evaluated by histologic examination. Transgenic SF coating incorporating VEGF and REDV demonstrated higher tissue infiltration and continuous endothelialization in the center of the graft compared to YIGSR at 4 weeks after implantation. VEGF and REDV are capable of endothelialization as early as 4 weeks after implantation, confirming the usefulness of transgenic SF when used as a porous coating. Full article
(This article belongs to the Special Issue Polymer-Based Coatings in Prosthetics Research)
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