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Herbal Products for Dermatologic Disorders: Chemistry and Applications
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Herbal Products for Dermatologic Disorders: Chemistry and Applications

A special issue of Sci (ISSN 2413-4155).

Deadline for manuscript submissions: closed (30 December 2021) | Viewed by 6581

Special Issue Editor

Prof. Dr. Helen D. Skaltsa

E-Mail Website
Guest Editor
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, 15771 Athens, Greece
Interests: chemistry of natural products; analytical methods; NMR; GC-MS; terpenes (iridoids, sesquiterpene lactones, and triterpenes); phenolics (flavonoids, phenols, phenolic acids, and lignans); essential oils; ethnopharmacology; history of pharmacy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Herbal products, based mainly on locally available plants, have been used for dermatologic disorders for thousands of years. From classic antiquity until the present, systems of herbal therapeutics have developed regionally all over the world. Although new synthetic therapeutic agents for skin disorders were introduced during the 20th century, the interest for natural remedies never disappeared, and herbal therapy has increased in popularity in the past two decades in parallel to current conventional allopathic medicines.

Today, several herbal products are used for common dermatologic disorders such as bacterial and fungal infections of the skin, wounds and burns, bruises, dermatitis, pruritus, acne, chronic venous insufficiency, and psoriasis.

This Special Issue of Sci aims to present a collection of original papers and/or review papers dealing with complementary and alternative approaches to the study of herbal products and their application in skin disorders. Submitted papers should be focused on phytochemical analyses and in vitro/or in vivo biological assays.

Prof. Dr. Helen D. Skaltsa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sci is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Plants
  • Secondary metabolites
  • Skin disorders
  • Phytochemical analysis
  • In vitro tests
  • In vivo tests

Published Papers (2 papers)

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Research

16 pages, 1320 KiB  
Article
Chemical Profile and In Vitro Evaluation of the Antibacterial Activity of Dioscorea communis Berry Juice
by Konstantina Tsami, Christina Barda, George Ladopoulos, Nikos Asoutis Didaras, Maria-Eleni Grafakou, Jörg Heilmann, Dimitris Mossialos, Michail Christou Rallis and Helen Skaltsa
Sci 2022, 4(2), 21; https://doi.org/10.3390/sci4020021 - 18 May 2022
Cited by 3 | Viewed by 3077
Abstract
Within the large family of Dioscoreaceae, Dioscorea communis (L.) Caddick & Wilkin (syn. Tamus communis L.) is considered among the four most widespread representatives in Europe, and it is commonly known under the name black bryony or bryonia. To date, reports have revealed [...] Read more.
Within the large family of Dioscoreaceae, Dioscorea communis (L.) Caddick & Wilkin (syn. Tamus communis L.) is considered among the four most widespread representatives in Europe, and it is commonly known under the name black bryony or bryonia. To date, reports have revealed several chemical components from the leaves and tubers of this plant. Nevertheless, an extensive phytochemical investigation has not been performed on its berry juice. In the present study, metabolite profiling procedures, using LC-MS, GC-MS, and NMR approaches, were applied to investigate the chemical profile of the D. communis berries. This work reveals the presence of several metabolites belonging to different phytochemical groups, such as fatty acid esters, alkylamides, phenolic derivatives, and organic acids, with lactic acid being predominant. In parallel, based on orally transmitted traditional uses, the initial extract and selected fractions were tested in vitro for their antibacterial effects and exhibited good activity against two bacterial strains related to skin infections: methicillin-resistant Staphylococcus aureus and Cutibacterium acnes. The MIC and MBC values of the extract were determined at 1.56% w/v against both bacteria. The results of this study provide important information on the chemical characterization of the D. communis berry juice, unveiling the presence of 71 metabolites, which might contribute to and further explain its specific antibacterial activity and its occasional toxicity. Full article
(This article belongs to the Special Issue Herbal Products for Dermatologic Disorders: Chemistry and Applications)
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16 pages, 2046 KiB  
Article
HPLC–NMR-Based Chemical Profiling of Matricaria pubescens (Desf.) Schultz and Matricaria recutita and Their Protective Effects on UVA-Exposed Fibroblasts
by Maria-Elena Ignatiadou, Maria Kostaki, Zahia Kabouche, Paschalina Chatzopoulou, Michail Christou Rallis and Anastasia Karioti
Sci 2022, 4(1), 14; https://doi.org/10.3390/sci4010014 - 18 Mar 2022
Cited by 2 | Viewed by 2757
Abstract
The present study aimed to investigate the chemical profile and the protective activity on fibroblasts of two Matricaria species: M. pubescens, which grows wild in Algeria, and M. recutita, which is cultivated in Greece. A comparative phytochemical investigation using High-Performance Liquid [...] Read more.
The present study aimed to investigate the chemical profile and the protective activity on fibroblasts of two Matricaria species: M. pubescens, which grows wild in Algeria, and M. recutita, which is cultivated in Greece. A comparative phytochemical investigation using High-Performance Liquid Chromatography, coupled with Photodiode Array Detection and Mass Spectrometry (HPLC–PDA–MS) combined with Nuclear Magnetic Resonance (NMR), was performed for the identification of the main constituents in the flowerheads of these medicinal plants. In M. pubescens more than 25 compounds were identified and/or isolated; among them are quercetagenin-3-O-glucopyranoside, reported for the first time in Matricaria sp., and two polyamines previously reported in other Asteraceae species. In M. recutita, which is the officially recognized species in Europe, 19 constituents were identified. To minimize time analysis, the structure elucidation was based on a multi-analytical approach directly on subfractions. Two representative polar extracts from each species were characterized chemically and further screened for their protective effects on 3T3 fibroblasts. The cells were exposed to a mild toxic dose of UVA light (6 J/cm2), in the presence of different concentrations of the extracts. Both M. recutita and M. pubescens extracts were effective. The methanolic extract was the best protective agent at lower concentrations (0.1 to 10 μg/mL), and hydromethanolic was best at higher ones (100–200 μg/mL). M. recutita exhibited the most enhanced cell viability in relation to those not exposed to UV control; it ranged from of 28 to 49% higher viability, depending on the dose, leading to the conclusion that the latter seems to exhibit potent cytoprotective activity and significant regeneration activity. Full article
(This article belongs to the Special Issue Herbal Products for Dermatologic Disorders: Chemistry and Applications)
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