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Label-Free Biosensors for Medicine and Biotechnology
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Label-Free Biosensors for Medicine and Biotechnology

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 6592

Special Issue Editors

Prof. Dr. Joshua A. Jackman

E-Mail Website
Guest Editor
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
Interests: biosensors; interfacial science; biophysics; translational medicine; biotechnology
Special Issues, Collections and Topics in MDPI journals
Prof. Nam-Joon Cho

E-Mail Website
Guest Editor
Nanyang Technological University, School of Materials Science and Engineering, Singapore
Interests: biointerfacial science; acoustic sensors; optical sensors; nanoplasmonic sensors; lipid membranes; membrane-active peptides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There has been tremendous progress in the design and application of label-free biosensors for a wide range of medicine and biotechnology applications. Key application areas include, but are not limited to, diagnostics, bioanalytical tools, smart stimuli-responsive systems, and energy-generating sensing devices. This Special Issue focuses on covering the latest developments in label-free biosensors for medicine and biotechnology. Topics related to various transducing mechanisms, such as optical, acoustic, and electrochemical types, are broadly welcome. This Special Issue is suitable for novel biosensor designs as well as for new applications of existing biosensors, including performance testing.

We welcome submissions from any area of biosensing, provided that the basic measurement strategy involves a label-free readout. Both research papers and review articles will be considered. If you are interested in contributing to this Special Issue, we would very much appreciate receiving the tentative title of your contribution.

Prof. Joshua A. Jackman
Prof. Nam-Joon Cho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical sensors
  • acoustic sensors
  • piezoelectric sensors
  • electrochemical sensors
  • lab-on-a-chip
  • surface functionalization
  • diagnostics
  • point-of-care
  • bioanalytical
  • nanoplasmonics
  • electrical stimulation
  • smart sensors

Published Papers (2 papers)

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Research

14 pages, 2899 KiB  
Article
Pentacyanoammineferrate-Based Non-Enzymatic Electrochemical Biosensing Platform for Selective Uric Acid Measurement
by Won-Yong Jeon, Chang-Jun Lee, Tun Naw Sut, Hyug-Han Kim and Young-Bong Choi
Sensors 2021, 21(5), 1574; https://doi.org/10.3390/s21051574 - 24 Feb 2021
Cited by 4 | Viewed by 1961
Abstract
The electrochemical-based detection of uric acid (UA) is widely used for diagnostic purposes. However, various interfering species such as ascorbic acid, dopamine, and glucose can affect electrochemical signals, and hence there is an outstanding need to develop improved sensing platforms to detect UA [...] Read more.
The electrochemical-based detection of uric acid (UA) is widely used for diagnostic purposes. However, various interfering species such as ascorbic acid, dopamine, and glucose can affect electrochemical signals, and hence there is an outstanding need to develop improved sensing platforms to detect UA with high selectivity. Herein, we report a pentagonal mediator-based non-enzymatic electrochemical biosensing platform to selectively measure UA in the presence of interfering species. The working electrode was fabricated by electrodepositing polymerized 1-vinylimidazole (PVI), which has an imidazole ligand, onto indium tin oxide (ITO), and then conjugating nickel ions to the PVI-coated ITO electrode. Electrode performance was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) measurements and integrated together with pentacyanoammineferrate, which can bind to the amine groups of UA and function as an electron transferring mediator. The experimental results showed a wide linear range of UA concentration-dependent responses and the multi-potential step (MPS) technique facilitated selective detection of UA in the presence of physiologically relevant interfering species. Altogether, these findings support that pentacyanoammineferrate-based non-enzymatic electrodes are suitable biosensing platforms for the selective measurement of UA, and such approaches could potentially be extended to other bioanalytes as well. Full article
(This article belongs to the Special Issue Label-Free Biosensors for Medicine and Biotechnology)
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16 pages, 3083 KiB  
Article
Electrochemical Immunosensor for the Early Detection of Rheumatoid Arthritis Biomarker: Anti-Cyclic Citrullinated Peptide Antibody in Human Serum Based on Avidin-Biotin System
by Somasekhar R. Chinnadayyala and Sungbo Cho
Sensors 2021, 21(1), 124; https://doi.org/10.3390/s21010124 - 28 Dec 2020
Cited by 19 | Viewed by 4083
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune disease that produces a progressive inflammatory response that leads to severe pain, swelling, and stiffness in the joints of hands and feet, followed by irreversible damage of the joints. The authors developed a miniaturized, label-free electrochemical [...] Read more.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that produces a progressive inflammatory response that leads to severe pain, swelling, and stiffness in the joints of hands and feet, followed by irreversible damage of the joints. The authors developed a miniaturized, label-free electrochemical impedimetric immunosensor for the sensitive and direct detection of arthritis Anti-CCP-ab biomarker. An interdigitated-chain-shaped microelectrode array (ICE) was fabricated by taking the advantage of microelectromechanical systems. The fabricated ICE was modified with a self-assembled monolayer (SAM) of Mercaptohexanoic acid (MHA) for immobilization of the synthetic peptide bio-receptor (B-CCP). The B-CCP was attached onto the surface of SAM modified ICE through a strong avidin-biotin bio-recognition system. The modified ICE surface with the SAM and bio-molecules (Avidin, B-CCP, Anti-CCP-ab and BSA) was morphologically and electrochemically characterized. The change in the sensor signal upon analyte binding on the electrode surface was probed through the electrochemical impedance spectroscopy (EIS) property of charge-transfer resistance (Rct) of the modified electrodes. EIS measurements were target specific and the sensor response was linearly increased with step wise increase in target analyte (Anti-CCP-ab) concentrations. The developed sensor showed a linear range for the addition of Anti-CCP-ab between 1 IU mL−1 → 800 IU mL−1 in phosphate buffered saline (PBS) and Human serum (HS), respectively. The sensor showed a limit of detection of 0.60 IU mL−1 and 0.82 IU mL−1 in the PBS and HS, respectively. The develop bio-electrode showed a good reproducibility (relative standard deviation (RSD), 1.52%), selectivity and stability (1.5% lost at the end of 20th day) with an acceptable recovery rate (98.0% → 101.18%) and % RSD’s for the detection of Anti-CCP-ab in spiked HS samples. Full article
(This article belongs to the Special Issue Label-Free Biosensors for Medicine and Biotechnology)
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