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Sensors
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Label-Free Biosensors for Medicine and Biotechnology II
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Label-Free Biosensors for Medicine and Biotechnology II

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biomedical Sensors".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 2608

Special Issue Editors

Prof. Dr. Joshua A. Jackman

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Guest Editor
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea
Interests: biosensors; interfacial science; biophysics; translational medicine; biotechnology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Nam-Joon Cho

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Interests: biosensing, hydrogel tissue engineering, biopharmaceuticals and drug delivery.
Special Issues, Collections and Topics in MDPI journals
Dr. Bo Kyeong Yoon

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Guest Editor
School of Healthcare and Biomedical Engineering, Chonnam National University, Yeosu 59626, Republic of Korea
Interests: antimicrobial lipids; lipid membrane biotechnology; biosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There has been tremendous progress in the design and application of label-free biosensors for a wide range of medicine and biotechnology applications. Key application areas include but are not limited to diagnostics, bioanalytical tools, smart stimuli-responsive systems, and energy-generating sensing devices. This Special Issue focuses on covering the latest developments in label-free biosensors for medicine and biotechnology. Topics related to various transducing mechanisms, such as optical, acoustic, and electrochemical types, are broadly welcome. This Special Issue is suitable for novel biosensor designs as well as for new applications of existing biosensors, including performance testing.

We welcome submissions from any area of biosensing, provided that the basic measurement strategy involves a label-free readout. Both research papers and review articles will be considered. If you are interested in contributing to this Special Issue, we would very much appreciate receiving the tentative title of your contribution.

Prof. Dr. Joshua A. Jackman
Prof. Dr. Nam-Joon Cho
Dr. Bo Kyeong Yoon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical sensors
  • acoustic sensors
  • piezoelectric sensors
  • electrochemical sensors
  • lab-on-a-chip
  • surface functionalization
  • diagnostics
  • point-of-care
  • bioanalytical
  • nanoplasmonics
  • electrical stimulation
  • smart sensors

Published Papers (1 paper)

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Research

14 pages, 3667 KiB  
Article
Mechanistic Evaluation of Antimicrobial Lipid Interactions with Tethered Lipid Bilayers by Electrochemical Impedance Spectroscopy
by Sue Woon Tan, Won-Yong Jeon, Bo Kyeong Yoon and Joshua A. Jackman
Sensors 2022, 22(10), 3712; https://doi.org/10.3390/s22103712 - 13 May 2022
Cited by 13 | Viewed by 2093
Abstract
There is extensive interest in developing real-time biosensing strategies to characterize the membrane-disruptive properties of antimicrobial lipids and surfactants. Currently used biosensing strategies mainly focus on tracking membrane morphological changes such as budding and tubule formation, while there is an outstanding need to [...] Read more.
There is extensive interest in developing real-time biosensing strategies to characterize the membrane-disruptive properties of antimicrobial lipids and surfactants. Currently used biosensing strategies mainly focus on tracking membrane morphological changes such as budding and tubule formation, while there is an outstanding need to develop a label-free biosensing strategy to directly evaluate the molecular-level mechanistic details by which antimicrobial lipids and surfactants disrupt lipid membranes. Herein, using electrochemical impedance spectroscopy (EIS), we conducted label-free biosensing measurements to track the real-time interactions between three representative compounds—glycerol monolaurate (GML), lauric acid (LA), and sodium dodecyl sulfate (SDS)—and a tethered bilayer lipid membrane (tBLM) platform. The EIS measurements verified that all three compounds are mainly active above their respective critical micelle concentration (CMC) values, while also revealing that GML induces irreversible membrane damage whereas the membrane-disruptive effects of LA are largely reversible. In addition, SDS micelles caused membrane solubilization, while SDS monomers still caused membrane defect formation, shedding light on how antimicrobial lipids and surfactants can be active in, not only micellar form, but also as monomers in some cases. These findings expand our mechanistic knowledge of how antimicrobial lipids and surfactants disrupt lipid membranes and demonstrate the analytical merits of utilizing the EIS sensing approach to comparatively evaluate membrane-disruptive antimicrobial compounds. Full article
(This article belongs to the Special Issue Label-Free Biosensors for Medicine and Biotechnology II)
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