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Sensors and Actuators for Wearable and Implantable Devices

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Physical Sensors".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 27817

Special Issue Editors


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Guest Editor
School of Engineering and Built Environment, Griffith University, Nathan, QLD 4111, Australia
Interests: integrated circuit; VLSI; MEMS; piezoelectric films
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia (UKM)
Interests: MEMS/NEMS, nanoelectronics, microenergy, bio-MEMS, lab-on-chip, biomedical devices

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Guest Editor
Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia (UKM)
Interests: MEMS/NEMS, micro-nano fabrication, lab-on-chip, biomedical technologies

Special Issue Information

Dear Colleagues,

Wearable and implantable devices have sustainable academic and commercial interests over the years. Some examples for wearable devices include vital signs monitoring such as smart watches, portable dialysis systems, and pacemakers. The artificial heart, artificial cochlear, and artificial kidney are the examples of implantable systems. Such devices/systems would not be possible without the use of micro-sensors to detect temperature, pressure, protein, ions, flow rate, occulation, bubble, pH etc. Correspondingly, several actuators are being employed such as micro-pumps, micro-filters, micro-valves, dielectrophoresis based separation devices etc. Most of these devices/systems are self-operated and self-monitored via signal processing circuitries, while some have wireless data transfer capability to the clouds for big data analysis and storage.

This Special Issue solicits review and original articles on the state-of-the-art sensors and actuators for wearable and implantable devices. We are also interested with the fabrication and processing of functional materials for such purposes, algorithms for the smart monitoring of the systems, and system-level development of the aforementioned clusters in the large network such as in hospital. In addition, articles that address the practical issues such as the signal processing circuitries, low power design, self-powered capability, bio-compatible and ergonomic packaging, robust manufacturing, comprehensive testing, and system integration for these sensors and actuators and their systems are also welcomed.

Dr. Faisal Mohd-Yasin
Prof. Azrul Azlan Hamzah
Prof. Burhanuddin Yeop Majlis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical device
  • wearable device
  • implantable device
  • ambulatory device
  • health and vital signs monitoring
  • artificial organ
  • pressure sensor
  • protein sensor
  • ion sensor
  • flow sensor
  • occulation sensor
  • bubble sensor
  • pH sensor
  • temperature sensor
  • micro-pump
  • micro-filter
  • micro-valve
  • dielectrophoresis
  • smart material
  • functional material
  • smart monitoring
  • big data analysis
  • electronics
  • wireless sensor network
  • biocompatible packaging
  • energy harvesting

Published Papers (8 papers)

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Research

13 pages, 4017 KiB  
Article
An Adaptive Pedaling Assistive Device for Asymmetric Torque Assistant in Cycling
by Jesse Lozinski, Seyed Hamidreza Heidary, Scott C. E. Brandon and Amin Komeili
Sensors 2023, 23(5), 2846; https://doi.org/10.3390/s23052846 - 06 Mar 2023
Cited by 3 | Viewed by 2000
Abstract
Dynamic loads have short and long-term effects in the rehabilitation of lower limb joints. However, an effective exercise program for lower limb rehabilitation has been debated for a long time. Cycling ergometers were instrumented and used as a tool to mechanically load the [...] Read more.
Dynamic loads have short and long-term effects in the rehabilitation of lower limb joints. However, an effective exercise program for lower limb rehabilitation has been debated for a long time. Cycling ergometers were instrumented and used as a tool to mechanically load the lower limbs and track the joint mechano-physiological response in rehabilitation programs. Current cycling ergometers apply symmetrical loading to the limbs, which may not reflect the actual load-bearing capacity of each limb, as in Parkinson’s and Multiple Sclerosis diseases. Therefore, the present study aimed to develop a new cycling ergometer capable of applying asymmetric loads to the limbs and validate its function using human tests. The instrumented force sensor and crank position sensing system recorded the kinetics and kinematics of pedaling. This information was used to apply an asymmetric assistive torque only to the target leg using an electric motor. The performance of the proposed cycling ergometer was studied during a cycling task at three different intensities. It was shown that the proposed device reduced the pedaling force of the target leg by 19% to 40%, depending on the exercise intensity. This reduction in pedal force caused a significant reduction in the muscle activity of the target leg (p < 0.001), without affecting the muscle activity of the non-target leg. These results demonstrated that the proposed cycling ergometer device is capable of applying asymmetric loading to lower limbs, and thus has the potential to improve the outcome of exercise interventions in patients with asymmetric function in lower limbs. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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10 pages, 1532 KiB  
Article
Surface Acoustic Wave Propagation of GaN/Sapphire Integrated with a Gold Guiding Layer
by Muhammad Musoddiq Jaafar, Mohd Farhanulhakim Mohd Razip Wee, Hoang-Tan-Ngoc Nguyen, Le Trung Hieu, Rahul Rai, Ashish Kumar Sahoo, Chang Fu Dee, Edward Yi Chang, Burhanuddin Yeop Majlis and Clarence Augustine TH Tee
Sensors 2023, 23(5), 2464; https://doi.org/10.3390/s23052464 - 23 Feb 2023
Cited by 1 | Viewed by 1548
Abstract
Gallium nitride (GaN), widely known as a wide bandgap semiconductor material, has been mostly employed in high power devices, light emitting diodes (LED), and optoelectronic applications. However, it could be exploited differently due to its piezoelectric properties, such as its higher SAW velocity [...] Read more.
Gallium nitride (GaN), widely known as a wide bandgap semiconductor material, has been mostly employed in high power devices, light emitting diodes (LED), and optoelectronic applications. However, it could be exploited differently due to its piezoelectric properties, such as its higher SAW velocity and strong electromechanical coupling. In this study, we investigated the affect of the presence of a guiding layer made from titanium/gold on the surface acoustic wave propagation of the GaN/sapphire substrate. By fixing the minimum thickness of the guiding layer at 200 nm, we could observe a slight frequency shift compared to the sample without a guiding layer, with the presence of different types of surface mode waves (Rayleigh and Sezawa). This thin guiding layer could be efficient in transforming the propagation modes, acting as a sensing layer for the binding of biomolecules to the gold layer, and influencing the output signal in terms of frequency or velocity. The proposed GaN/sapphire device integrated with a guiding layer could possibly be used as a biosensor and in wireless telecommunication applications. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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21 pages, 5487 KiB  
Article
Evaluation Methodology of a Smart Clothing Biomechanical Energy Harvesting System for Mountain Rescuers
by Bartosz Pękosławski, Łukasz Starzak, Anna Dąbrowska and Grażyna Bartkowiak
Sensors 2021, 21(3), 905; https://doi.org/10.3390/s21030905 - 29 Jan 2021
Cited by 4 | Viewed by 2081
Abstract
The article presents a methodology developed for the evaluation of biomechanical energy harvesting systems that permits avoiding long-duration outdoor tests while providing realistic input signals and preserving uniform conditions across repeated tests. It consists of two stages: transducer output signal recording and power [...] Read more.
The article presents a methodology developed for the evaluation of biomechanical energy harvesting systems that permits avoiding long-duration outdoor tests while providing realistic input signals and preserving uniform conditions across repeated tests. It consists of two stages: transducer output signal recording and power conversion and storage system measurements. The proposed approach was applied to assess the usefulness of a commercial electromagnetic transducer for supplying a Global Positioning System (GPS) receiver used as an active component of a smart clothing dedicated for mountain rescuers. Electrical power yield measurements have been presented together with ergonomic tests results. They all involved diverse physical activities performed by mountain rescuers that simulated their true operations, but were conducted in a training room for the sake of standardization. By providing reliable data on the transducer’s performance under realistic use conditions, the proposed evaluation procedure revealed that the true energy yield was much smaller not only with respect to the manufacturer’s assertions, but also substantially lower than what was expected based on an independent review which used unrealistic and non-uniform excitations. On the other hand, ergonomics ratings given by potential end users were very high, which demonstrates that the evaluated transducer can still be useful for supplying active cloth components with a lower power demand. The study also revealed that transducer location and orientation strongly affect its performance, which must be taken into account at the first stage of the evaluation procedure. Moreover, physical activity type and conditions (such as motion speed and ground tilt) influence the output power and should be carefully considered when composing a typical case scenario for the second stage. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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14 pages, 5689 KiB  
Article
Encapsulation of Capacitive Micromachined Ultrasonic Transducers (CMUTs) for the Acoustic Communication between Medical Implants
by Jorge Oevermann, Peter Weber and Steffen H. Tretbar
Sensors 2021, 21(2), 421; https://doi.org/10.3390/s21020421 - 09 Jan 2021
Cited by 4 | Viewed by 2816
Abstract
The aim of this work was to extend conventional medical implants by the possibility of communication between them. For reasons of data security and transmitting distances, this communication should be realized using ultrasound, which is generated and detected by capacitive micromachined ultrasonic transducers [...] Read more.
The aim of this work was to extend conventional medical implants by the possibility of communication between them. For reasons of data security and transmitting distances, this communication should be realized using ultrasound, which is generated and detected by capacitive micromachined ultrasonic transducers (CMUTs). These offer the advantage of an inherent high bandwidth and a high integration capability. To protect the surrounding tissue, it has to be encapsulated. In contrast to previous results of other research groups dealing with the encapsulation of CMUTs, the goal here is to integrate the CMUT into the housing of a medical implant. In this work, CMUTs were designed and fabricated for a center frequency of 2 MHz in water and experimentally tested on their characteristics for operation behind layers of Polyether ether ketone (PEEK) and titanium, two typical materials for the housings of medical implants. It could be shown that with silicone as a coupling layer it is possible to operate a CMUT behind the housing of an implant. Although it changes the characteristics of the CMUT, the setup is found to be well suited for communication between two transducers over a distance of at least 8 cm. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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11 pages, 1872 KiB  
Article
Modeling and Prediction of Wearable Energy Harvesting Sliding Shoes for Metabolic Cost and Energy Rate Outside of the Lab
by Peter B. Shull and Haisheng Xia
Sensors 2020, 20(23), 6915; https://doi.org/10.3390/s20236915 - 03 Dec 2020
Cited by 4 | Viewed by 2331
Abstract
The recent explosion of wearable electronics has led to widespread interest in harvesting human movement energy, particularly during walking, for clinical and health applications. However, the amount of energy available to harvest and the required metabolic rate for wearable energy harvesting varies across [...] Read more.
The recent explosion of wearable electronics has led to widespread interest in harvesting human movement energy, particularly during walking, for clinical and health applications. However, the amount of energy available to harvest and the required metabolic rate for wearable energy harvesting varies across subjects. In this paper, we utilize custom energy harvesting sliding shoes to develop and evaluate multivariate linear regression models to predict metabolic rate and energy harvesting rate during overground walking outside of the lab. Subjects performed 200 m self-selected normal and fast walking trials on flat ground with custom sliding shoes. Metabolic rate was measured with a portable breathing analysis system and energy harvesting rate was measured directly from the generator on the custom sliding shoes. Model performance was determined by comparing the difference between actual and predicted metabolic and energy harvesting rates. Overall, predictive modeling closely matched the actual values, and there was no statistical difference between actual and predicted average metabolic rate or between actual and predicted average energy harvesting rate. Energy harvesting sliding shoes could potentially be used for a variety of wearable devices to reduce onboard energy storage, and these findings could serve to inform expected energy harvesting rates and associated required metabolic cost for a diverse array of medical and health applications. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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16 pages, 3299 KiB  
Article
Ultrasensitive and Highly Selective Graphene-Based Field-Effect Transistor Biosensor for Anti-Diuretic Hormone Detection
by Reena Sri Selvarajan, Ruslinda A. Rahim, Burhanuddin Yeop Majlis, Subash C. B. Gopinath and Azrul Azlan Hamzah
Sensors 2020, 20(9), 2642; https://doi.org/10.3390/s20092642 - 06 May 2020
Cited by 21 | Viewed by 6216
Abstract
Nephrogenic diabetes insipidus (NDI), which can be congenital or acquired, results from the failure of the kidney to respond to the anti-diuretic hormone (ADH). This will lead to excessive water loss from the body in the form of urine. The kidney, therefore, has [...] Read more.
Nephrogenic diabetes insipidus (NDI), which can be congenital or acquired, results from the failure of the kidney to respond to the anti-diuretic hormone (ADH). This will lead to excessive water loss from the body in the form of urine. The kidney, therefore, has a crucial role in maintaining water balance and it is vital to restore this function in an artificial kidney. Herein, an ultrasensitive and highly selective aptameric graphene-based field-effect transistor (GFET) sensor for ADH detection was developed by directly immobilizing ADH-specific aptamer on a surface-modified suspended graphene channel. This direct immobilization of aptamer on the graphene surface is an attempt to mimic the functionality of collecting tube V 2 receptors in the ADH biosensor. This aptamer was then used as a probe to capture ADH peptide at the sensing area which leads to changes in the concentration of charge carriers in the graphene channel. The biosensor shows a significant increment in the relative change of current ratio from 5.76 to 22.60 with the increase of ADH concentration ranging from 10 ag/mL to 1 pg/mL. The ADH biosensor thus exhibits a sensitivity of 50.00 µA· ( g / mL ) 1 with a limit of detection as low as 3.55 ag/mL. In specificity analysis, the ADH biosensor demonstrated a higher current value which is 338.64 µA for ADH-spiked in phosphate-buffered saline (PBS) and 557.89 µA for ADH-spiked in human serum in comparison with other biomolecules tested. This experimental evidence shows that the ADH biosensor is ultrasensitive and highly selective towards ADH in PBS buffer and ADH-spiked in human serum. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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8 pages, 2895 KiB  
Article
Fabrication of Si Micropore and Graphene Nanohole Structures by Focused Ion Beam
by Nik Noor Nabilah Md Ibrahim and Abdul Manaf Hashim
Sensors 2020, 20(6), 1572; https://doi.org/10.3390/s20061572 - 12 Mar 2020
Cited by 2 | Viewed by 3202
Abstract
A biosensor formed by a combination of silicon (Si) micropore and graphene nanohole technology is expected to act as a promising device structure to interrogate single molecule biopolymers, such as deoxyribonucleic acid (DNA). This paper reports a novel technique of using a focused [...] Read more.
A biosensor formed by a combination of silicon (Si) micropore and graphene nanohole technology is expected to act as a promising device structure to interrogate single molecule biopolymers, such as deoxyribonucleic acid (DNA). This paper reports a novel technique of using a focused ion beam (FIB) as a tool for direct fabrication of both conical-shaped micropore in Si3N4/Si and a nanohole in graphene to act as a fluidic channel and sensing membrane, respectively. The thinning of thick Si substrate down to 50 µm has been performed prior to a multi-step milling of the conical-shaped micropore with final pore size of 3 µm. A transfer of graphene onto the fabricated conical-shaped micropore with little or no defect was successfully achieved using a newly developed all-dry transfer method. A circular shape graphene nanohole with diameter of about 30 nm was successfully obtained at beam exposure time of 0.1 s. This study opens a breakthrough in fabricating an integrated graphene nanohole and conical-shaped Si micropore structure for biosensor applications. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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20 pages, 6778 KiB  
Article
Design and Control of a Polycentric Knee Exoskeleton Using an Electro-Hydraulic Actuator
by Taesik Lee, Dongyoung Lee, Buchun Song and Yoon Su Baek
Sensors 2020, 20(1), 211; https://doi.org/10.3390/s20010211 - 30 Dec 2019
Cited by 40 | Viewed by 6177
Abstract
An exoskeleton robot helps the wearer with mechanical forces by identifying the wearer’s intentions and requires high energy efficiency, sufficient load capacity, and a comfortable fit. However, since it is difficult to implement complex anatomical movements of the human body, most exoskeleton robots [...] Read more.
An exoskeleton robot helps the wearer with mechanical forces by identifying the wearer’s intentions and requires high energy efficiency, sufficient load capacity, and a comfortable fit. However, since it is difficult to implement complex anatomical movements of the human body, most exoskeleton robots are designed simply, unlike the anatomy of real humans. This forces the wearer to accept the robot’s stiffness entirely, and to use energy inefficiently from the power source. In this paper, a simple 1 degree of freedom (DoF) structure, which was mainly used in the knees of exoskeleton robots, was designed with a polycentric (multi-axial) structure to minimize the misalignment between wearer and robot, so that torque transfer could be carried out efficiently. In addition, the overall robot system was constructed by using an electro-hydraulic actuator (EHA) to solve the problems of the energy inefficiency of conventional hydraulic actuators and the low load capacity of conventional electric actuators. After the configuration of the hardware system, the sliding mode controller was designed to address the EHA nonlinear models and the uncertainty of the plant design. This was configured as Simulink for the first verification, and the experiment was conducted by applying it to the actual model to demonstrate the performance of the sliding mode control. In this process, an optical rotary encoder was used as the main feedback sensor of the controller. The proposed polycentric knee exoskeleton robot system using the EHA was able to reach the desired target value well despite the presence of many model uncertainties. Full article
(This article belongs to the Special Issue Sensors and Actuators for Wearable and Implantable Devices)
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