Special Issue "Aptasensors 2016"
Deadline for manuscript submissions: closed (15 February 2017)
Dr. Beate Strehlitz
Department Environmental and Biotechnology Centre, Helmholtz Centre for Environmental Research – UFZ, Permoserstr. 15, 04318 Leipzig, Germany
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Phone: +49 341 2351764
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Interests: aptamer selection and characterization; SELEX; aptamer based sensors and assays; biosensor development and application; bioelectrotechnology; bioelectrochemistry
The last year was the 25th anniversary of the ‘aptamer’ termed functional biomacromolecules and of the in vitro selection and amplification technology (SELEX) used for their development. In 1990, Tuerk & Gold and Ellington & Szostak, independently described their discoveries to generate RNA aptamers able to bind a protein molecule (Science 249, 1990, 505–510) and synthetic organic dyes (Nature 346, 1990, 818–822), respectively. Aptamers are still very attractive functional molecules that are applied by researchers from different disciplines in areas such as nanotechnology, synthetic and chemical biology, analytics, clinical diagnostics, and therapy. The discovery of high-quality aptamers for relevant targets proceeds. The first commercial products based on aptamers are on the market, such as Macugen® (Pfizer Inc., US) as a therapeutic aptamer to treat wet macular degeneration; the ELISA-like assays for detection of Ochratoxin A and aflatoxin (NeoVentures Biotechnologies, Canada); and others. In addition to these applications, aptamers are in great demand in the development of new biosensors, the so-called aptasensors. The aptamers are used as sensitive and selective bio-receptors coupled with a variety of transducer principles, such as optical, mass-sensitive, and electrochemical detection. The analytes cover a wide range from small molecules, such as nucleotides, cofactors, amino acids, organic molecules over peptides, polysaccharides and proteins to complex structures such as whole cells, viruses, and single cell organisms. Aptasensors offer great potential to measure substances in clinical diagnostics, environmental analytics, food and biotechnology industries, process engineering, and others.
With this re-opening of the Special Issue, we invite you again to contribute with your full research papers and review articles showing the highly-dynamic evolvements in the field of aptasensor development. We look forward to and welcome your participation in this Special Issue.
Dr. Beate Strehlitz
Manuscript Submission Information
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- affinity sensor
- mass sensitive
- label- and label-free detection