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Electromagnetic Medical Sensing

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Physical Sensors".

Deadline for manuscript submissions: closed (31 August 2018) | Viewed by 91769

Special Issue Editor


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Guest Editor
Director of Research & Microwave Group Leader, School of ITEE, The University of Queensland, Office 616, Building 78, St Lucia QLD 4072, Australia
Interests: electromagnetic imaging; microwave imaging; hyperthermia; implantable antennas; UWB antennas; microwave devices; microwave biosensors

Special Issue Information

Dear Colleagues,

In recent years, electromagnetic (EM) techniques have been widely investigated and researched for different medical applications, from early diagnosis to therapy and monitoring. It is well known that biological tissues have specific dielectric properties, which are usually frequency dispersive. Any change in the physiological and pathological conditions of those tissues change those dielectric properties, and thus the response of the affected tissues to EM waves will change. Moreover, EM waves interact strongly with biological tissues, and thus, they deliver via that interaction specific energy to those tissues. Consequently, electromagnetic sensors can be designed and used to detect, image, and monitor those changes or as a therapeutic tool for the affected tissues. Moreover, any research on medical sensing based on EM techniques will need to look at dosimetry levels and ensure subject safety. 

Many techniques have already been formulated to enable the use of electromagnetic sensing methods in either non-invasive or invasive assessment, therapy and monitoring of the functional and pathological conditions of tissues. This Special Issue of Sensors aims at reporting on recent research efforts on this increasingly important topic. Its scope covers sensing devices, systems, sub-systems, techniques, and protocols designed to use electromagnetics, at any band from very low frequency to millimetre waves, for medical applications.

Prof. Dr. Amin Abbosh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • beamforming
  • electromagnetic imaging
  • digestible sensors
  • electromagnetic capsule
  • electromagnetic-guided therapy
  • hyperthermia hypoglycaemia sensors
  • microwave imaging
  • MRI compatibility of sensors
  • implantable devices
  • implantable antennas
  • bio monitoring
  • transcranial magnetic stimulation
  • tomography
  • microwave ablation
  • RFID sensors
  • wearable sensors

Published Papers (10 papers)

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Editorial

Jump to: Research, Review

4 pages, 134 KiB  
Editorial
Electromagnetic Medical Sensing
by Amin Abbosh
Sensors 2019, 19(7), 1662; https://doi.org/10.3390/s19071662 - 08 Apr 2019
Cited by 3 | Viewed by 4150
Abstract
In recent years, electromagnetic (EM) techniques have been widely investigated and researched for different medical applications, from early diagnosis to therapy and monitoring [...] Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)

Research

Jump to: Editorial, Review

14 pages, 7393 KiB  
Article
Three-Dimensional Electromagnetic Torso Scanner
by Sasan Ahdi Rezaeieh, Ali Zamani, Konstanty S. Bialkowski, Graeme A. Macdonald and Amin M. Abbosh
Sensors 2019, 19(5), 1015; https://doi.org/10.3390/s19051015 - 27 Feb 2019
Cited by 10 | Viewed by 3856
Abstract
A three-dimensional (3D) electromagnetic torso scanner system is presented. This system aims at providing a complimentary/auxiliary imaging modality to supplement conventional imaging devices, e.g., ultrasound, computerized tomography (CT) and magnetic resonance imaging (MRI), for pathologies in the chest and upper abdomen such as [...] Read more.
A three-dimensional (3D) electromagnetic torso scanner system is presented. This system aims at providing a complimentary/auxiliary imaging modality to supplement conventional imaging devices, e.g., ultrasound, computerized tomography (CT) and magnetic resonance imaging (MRI), for pathologies in the chest and upper abdomen such as pulmonary abscess, fatty liver disease and renal cancer. The system is comprised of an array of 14 resonance-based reflector (RBR) antennas that operate from 0.83 to 1.9 GHz and are located on a movable flange. The system is able to scan different regions of the chest and upper abdomen by mechanically moving the antenna array to different positions along the long axis of the thorax with an accuracy of about 1 mm at each step. To verify the capability of the system, a three-dimensional imaging algorithm is proposed. This algorithm utilizes a fast frequency-based microwave imaging method in conjunction with a slice interpolation technique to generate three-dimensional images. To validate the system, pulmonary abscess was simulated within an artificial torso phantom. This was achieved by injecting an arbitrary amount of fluid (e.g., 30 mL of water), into the lungs regions of the torso phantom. The system could reliably and reproducibly determine the location and volume of the embedded target. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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13 pages, 939 KiB  
Article
Design and Experimental Validation of a Multiple-Frequency Microwave Tomography System Employing the DBIM-TwIST Algorithm
by Syed Ahsan, Ziwen Guo, Zhenzhuang Miao, Ioannis Sotiriou, Maria Koutsoupidou, Efthymios Kallos, George Palikaras and Panagiotis Kosmas
Sensors 2018, 18(10), 3491; https://doi.org/10.3390/s18103491 - 16 Oct 2018
Cited by 33 | Viewed by 3898
Abstract
We present a first prototype of a wideband microwave tomography system with potential application to medical imaging. The system relies on a compact and robust printed monopole antenna which can operate in the 1.0–3.0 GHz range when fully immersed in commonly used coupling [...] Read more.
We present a first prototype of a wideband microwave tomography system with potential application to medical imaging. The system relies on a compact and robust printed monopole antenna which can operate in the 1.0–3.0 GHz range when fully immersed in commonly used coupling liquids, such as glycerine–water solutions. By simulating the proposed imaging setup in CST Microwave Studio, we study the signal transmission levels and array sensitivity for different target and coupling liquid media. We then present the experimental prototype design and data acquisition process, and show good agreement between experimentally measured data and results from the CST simulations. We assess imaging performance by applying our previously proposed two-dimensional (2-D) DBIM TwIST-algorithm to both simulated and experimental datasets, and demonstrate that the system can reconstruct simple cylindrical targets at multiple frequencies. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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16 pages, 4524 KiB  
Article
A Transmission-Based Dielectric Property Probe for Clinical Applications
by Paul Meaney, Tomas Rydholm and Helena Brisby
Sensors 2018, 18(10), 3484; https://doi.org/10.3390/s18103484 - 16 Oct 2018
Cited by 15 | Viewed by 3204
Abstract
We have developed a transmission-based, open-ended coaxial dielectric probe that can be used in clinical situations and overcomes many of the limitations related to the typical reflection-based dielectric probes. The approach utilizes the low profile, open-ended coaxial cables enabling clinicians to still probe [...] Read more.
We have developed a transmission-based, open-ended coaxial dielectric probe that can be used in clinical situations and overcomes many of the limitations related to the typical reflection-based dielectric probes. The approach utilizes the low profile, open-ended coaxial cables enabling clinicians to still probe relatively compact spaces. The sensing depth can be extended to as large as 1.5 to 2 cm compared with the more typical range of 0.3 mm for conventional probes and is dramatically less affected by measurement technique variability including poor sample contact and cable bending. As a precursor to an actual clinical implementation, we study the technique in a range of homogeneous liquids with substantially varying dielectric properties. The initial results demonstrate good agreement between the transmission-based probe and commercial, reflection-based probes and pave the way for more substantial clinical implementation. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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14 pages, 2306 KiB  
Article
Concentric Ring Probe for Bioimpedance Spectroscopic Measurements: Design and Ex Vivo Feasibility Testing on Pork Oral Tissues
by Shekh Emran, Reijo Lappalainen, Arja M. Kullaa and Sami Myllymaa
Sensors 2018, 18(10), 3378; https://doi.org/10.3390/s18103378 - 10 Oct 2018
Cited by 9 | Viewed by 4432
Abstract
Many oral diseases, such as oral leukoplakia and erythroplakia, which have a high potential for malignant transformations, cause abnormal structural changes in the oral mucosa. These changes are clinically assessed by visual inspection and palpation despite their poor accuracy and subjective nature. We [...] Read more.
Many oral diseases, such as oral leukoplakia and erythroplakia, which have a high potential for malignant transformations, cause abnormal structural changes in the oral mucosa. These changes are clinically assessed by visual inspection and palpation despite their poor accuracy and subjective nature. We hypothesized that non-invasive bioimpedance spectroscopy (BIS) might be a viable option to improve the diagnostics of potentially malignant lesions. In this study, we aimed to design and optimize the measurement setup and to conduct feasibility testing on pork oral tissues. The contact pressure between a custom-made concentric ring probe and tissue was experimentally optimized. The effects of loading time and inter-electrode spacing on BIS spectra were also clarified. Tissue differentiation testing was performed for ex vivo pork oral tissues including palatinum, buccal mucosa, fat, and muscle tissue samples. We observed that the most reproducible results were obtained by using a loading weight of 200 g and a fixed time period under press, which was necessary to allow meaningful quantitative comparison. All studied tissues showed their own unique spectra, accompanied by significant differences in both impedance magnitude and phase (p ≤ 0.014, Kruskal-Wallis test). BIS shows promise, and further studies are warranted to clarify its potential to detect specific pathological tissue alterations. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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12 pages, 1879 KiB  
Article
Monitoring and Assessing the Degradation Rate of Magnesium-Based Artificial Bone In Vitro Using a Wireless Magnetoelastic Sensor
by Limin Ren, Kun Yu and Yisong Tan
Sensors 2018, 18(9), 3066; https://doi.org/10.3390/s18093066 - 12 Sep 2018
Cited by 15 | Viewed by 3075
Abstract
A magnetoelastic-based (MB) sensor was employed as a novel method to monitor and assess the degradation rate of magnesium-based artificial bone (MBAB) in vitro, which can be used as an implant to repair a bone defect, providing a quantitative method to depict the [...] Read more.
A magnetoelastic-based (MB) sensor was employed as a novel method to monitor and assess the degradation rate of magnesium-based artificial bone (MBAB) in vitro, which can be used as an implant to repair a bone defect, providing a quantitative method to depict the degradation rate of MBAB. MBABs were fabricated by the Pro/Engineering software and a precision machine tool using high-purity (HP) magnesium. The MB sensor was embedded in the neutral surface of MBAB by an unharmful quick adhesive, forming the MB sensor-embedded MBAB (EMBAB). The modified simulated body fluid (MSBF) media (PH = 7.4), mimicking the human internal environment, and the NaOH media (PH = 12), accelerating EMBAB’s degradation, were used to immerse the EMBAB for 15 days at 37 °C. The EMBAB was then tested daily on a self-developed experimental platform to monitor the relative output power under a 100 N external force. The results showed that the relative output power of the sensing coil gradually increased with the EMBAB’s degradation. The degradation rate of the EMBAB could be calculated on the basis of the changes of the relative output power caused by the MB sensor and of the degradation time. With the EMBAB’s degradation, an increasing strain directly worked on the MB sensor, significantly changing the value of the relative output power, which means that the EMBAB was characterized by a quick degradation rate. During the 15 days of the experiment, the degradation rates on the 7th and 15th days were 0.005 dbm/day and 0.02 dbm/day, and 0.02 dbm/day and 0.04 dbm/day in MSBF and alkaline media, respectively. Therefore, the MB sensor provides a wireless and passive method to monitor and assess the degradation rate of bone implants in vitro. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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25 pages, 9274 KiB  
Article
Distorter Characterisation Using Mutual Inductance in Electromagnetic Tracking
by Herman Alexander Jaeger and Pádraig Cantillon-Murphy
Sensors 2018, 18(9), 3059; https://doi.org/10.3390/s18093059 - 12 Sep 2018
Cited by 8 | Viewed by 4828
Abstract
Electromagnetic tracking (EMT) is playing an increasingly important role in surgical navigation, medical robotics and virtual reality development as a positional and orientation reference. Though EMT is not restricted by line-of-sight requirements, measurement errors caused by magnetic distortions in the environment remain the [...] Read more.
Electromagnetic tracking (EMT) is playing an increasingly important role in surgical navigation, medical robotics and virtual reality development as a positional and orientation reference. Though EMT is not restricted by line-of-sight requirements, measurement errors caused by magnetic distortions in the environment remain the technology’s principal shortcoming. The characterisation, reduction and compensation of these errors is a broadly researched topic, with many developed techniques relying on auxiliary tracking hardware including redundant sensor arrays, optical and inertial tracking systems. This paper describes a novel method of detecting static magnetic distortions using only the magnetic field transmitting array. An existing transmitter design is modified to enable simultaneous transmission and reception of the generated magnetic field. A mutual inductance model is developed for this transmitter design in which deviations from control measurements indicate the location, magnitude and material of the field distorter to an approximate degree. While not directly compensating for errors, this work enables users of EMT systems to optimise placement of the magnetic transmitter by characterising a distorter’s effect within the tracking volume without the use of additional hardware. The discrimination capabilities of this method may also allow researchers to apply material-specific compensation techniques to minimise position error in the clinical setting. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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Review

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20 pages, 3391 KiB  
Review
Noninvasive Electromagnetic Wave Sensing of Glucose
by Ruochong Zhang, Siyu Liu, Haoran Jin, Yunqi Luo, Zesheng Zheng, Fei Gao and Yuanjin Zheng
Sensors 2019, 19(5), 1151; https://doi.org/10.3390/s19051151 - 07 Mar 2019
Cited by 60 | Viewed by 9418
Abstract
Diabetic patients need long-term and frequent glucose monitoring to assist in insulin intake. The current finger-prick devices are painful and costly, which places noninvasive glucose sensors in high demand. In this review paper, we list several advanced electromagnetic (EM)-wave-based technologies for noninvasive glucose [...] Read more.
Diabetic patients need long-term and frequent glucose monitoring to assist in insulin intake. The current finger-prick devices are painful and costly, which places noninvasive glucose sensors in high demand. In this review paper, we list several advanced electromagnetic (EM)-wave-based technologies for noninvasive glucose measurement, including infrared (IR) spectroscopy, photoacoustic (PA) spectroscopy, Raman spectroscopy, fluorescence, optical coherence tomography (OCT), Terahertz (THz) spectroscopy, and microwave sensing. The development of each method is discussed regarding the fundamental principle, system setup, and experimental results. Despite the promising achievements that have been previously reported, no established product has obtained FDA approval or survived a marketing test. The limitations of, and prospects for, these techniques are presented at the end of this review. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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45 pages, 6190 KiB  
Review
The Progress of Glucose Monitoring—A Review of Invasive to Minimally and Non-Invasive Techniques, Devices and Sensors
by Wilbert Villena Gonzales, Ahmed Toaha Mobashsher and Amin Abbosh
Sensors 2019, 19(4), 800; https://doi.org/10.3390/s19040800 - 15 Feb 2019
Cited by 342 | Viewed by 46792
Abstract
Current glucose monitoring methods for the ever-increasing number of diabetic people around the world are invasive, painful, time-consuming, and a constant burden for the household budget. The non-invasive glucose monitoring technology overcomes these limitations, for which this topic is significantly being researched and [...] Read more.
Current glucose monitoring methods for the ever-increasing number of diabetic people around the world are invasive, painful, time-consuming, and a constant burden for the household budget. The non-invasive glucose monitoring technology overcomes these limitations, for which this topic is significantly being researched and represents an exciting and highly sought after market for many companies. This review aims to offer an up-to-date report on the leading technologies for non-invasive (NI) and minimally-invasive (MI) glucose monitoring sensors, devices currently available in the market, regulatory framework for accuracy assessment, new approaches currently under study by representative groups and developers, and algorithm types for signal enhancement and value prediction. The review also discusses the future trend of glucose detection by analyzing the usage of the different bands in the electromagnetic spectrum. The review concludes that the adoption and use of new technologies for glucose detection is unavoidable and closer to become a reality. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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23 pages, 6275 KiB  
Review
Electromagnetic–Acoustic Sensing for Biomedical Applications
by Siyu Liu, Ruochong Zhang, Zesheng Zheng and Yuanjin Zheng
Sensors 2018, 18(10), 3203; https://doi.org/10.3390/s18103203 - 21 Sep 2018
Cited by 17 | Viewed by 6625
Abstract
This paper reviews the theories and applications of electromagnetic–acoustic (EMA) techniques (covering light-induced photoacoustic, microwave-induced thermoacoustic, magnetic-modulated thermoacoustic, and X-ray-induced thermoacoustic) belonging to the more general area of electromagnetic (EM) hybrid techniques. The theories cover excitation of high-power EM field (laser, microwave, magnetic [...] Read more.
This paper reviews the theories and applications of electromagnetic–acoustic (EMA) techniques (covering light-induced photoacoustic, microwave-induced thermoacoustic, magnetic-modulated thermoacoustic, and X-ray-induced thermoacoustic) belonging to the more general area of electromagnetic (EM) hybrid techniques. The theories cover excitation of high-power EM field (laser, microwave, magnetic field, and X-ray) and subsequent acoustic wave generation. The applications of EMA methods include structural imaging, blood flowmetry, thermometry, dosimetry for radiation therapy, hemoglobin oxygen saturation (SO2) sensing, fingerprint imaging and sensing, glucose sensing, pH sensing, etc. Several other EM-related acoustic methods, including magnetoacoustic, magnetomotive ultrasound, and magnetomotive photoacoustic are also described. It is believed that EMA has great potential in both pre-clinical research and medical practice. Full article
(This article belongs to the Special Issue Electromagnetic Medical Sensing)
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