Special Issue "Chemo- and Biosensors for Security and Defense"
Deadline for manuscript submissions: closed (31 March 2015)
Dr. Michael G. Weller (Website)
Head of Division 1.5, BAM Federal Institute for Materials Research and Testing, Richard-Willstaetter-Strasse 11, 12489 Berlin, Germany
Fax: 49 30 8104-1157
Interests: multiplexed biosensors; biochemical detection of explosives; quantitative protein analysis; affinity enrichment
Explosives, chemical weapons, and biological agents are a permanent menace in many countries around the world. Although various traditional methods exist to detect those hazards, they often are slow, expensive, unwieldy, lab-based, and usually lack sufficient sensitivity and selectivity, thus rendering them impracticable. The development of innovative detection methods for such agents is therefore one of the major challenges in modern analytical sciences.
In this Special Issue, we would like to focus on approaches which are based on the selective interaction of biochemical or chemical binders, such as antibodies, enzymes, aptamers, DNA and RNA in general, PNA, peptides, molecular imprinted polymers (MIPs), and the like.
Technologies, such as surface-plasmon resonance (SPR) sensors, surface-acoustic wave (SAW) sensors, quartz crystal microbalances (QMB), microcantilevers, other microelectromechanical systems (MEMS), fluorescence and chemiluminescence-based sensors, test strips, lateral flow assays, microarray biosensors and other multiplexed approaches, µ-total analysis systems (µ-TAS), lab-on-a-chip systems, and nanosensors are transducer platforms of interest for this issue. Technologies that deal with biological hazards, such as amplification-based assays utilizing polymerase chain reaction (PCR), rolling-circle amplification or loop-mediated isothermal amplification (LAMP) embedded in a sensor system, are also of substantial interest.
Dr. Michael G. Weller
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.
- chemical warfare
- biological weapons
- biological warfare
- homeland security
- improvised explosive device
- land mines
- public safety
- airport security
- security of mass transportation
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Detection of Explosives in a Dynamic Marine Environment Using a Moored TNT Immunosensor
Authors: Paul T. Charles 1,*, André A. Adams 1 , Jeffrey R. Deschamps 1, Scott Veitch 2, Al Hanson 2 and Anne W. Kusterbeck 1
Affiliation: 1 Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC, 20375, USA; E-Mails: firstname.lastname@example.org; email@example.com; Jeffrey.firstname.lastname@example.org; email@example.com
2 SubChem Systems, Inc., 65 Pier Road, Narragansett, RI 02882, USA; E-Mails: firstname.lastname@example.org; email@example.com
Abstract: A field demonstration and longevity assessment for long-term monitoring of the explosive, 2, 4, 6-trinitrotoluene (TNT) in a marine environment using an anti-TNT microfluidic immunosensor is described. The TNT immunosensor is comprised of a microfluidic device fabricated with 39 parallel microchannels (2.5 cm × 250 µm × 500 µm, L×W×D) in poly (methylmethacrylate) (PMMA) then chemically functionalized with antibodies possessing a high affinity for TNT. Synthesized fluorescence reporter complexes used in a displacement-based assay format were used for TNT identification. For field deployment the TNT immunosensor was configured onto a submersible moored steel frame along with frame controller, pumps and TNT plume generator and deployed pier side for intermittent plume sampling of TNT (1h increments). Under varying current and tidal conditions trace levels of TNT in natural seawater were detected over an extended period (>18h). Overnight operation and data recording was monitored via web interface.
Keywords: 2, 4, 6- Trinitrotoluene (TNT); explosives; immunosensor; seawater; fluorescence; remote