Chemistry for Life

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Chemistry: Symmetry/Asymmetry".

Deadline for manuscript submissions: closed (30 March 2021) | Viewed by 2365

Special Issue Editors


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Department of Pharmaceutical Sciences, Group of Catalysis, Synthesis and Organic Green Chemistry, University of Perugia, Perugia, Italy
Interests: organic synthesis; medicinal chemistry; selenium compounds
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Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 7 Gagarin Street, 87-100 Torun, Poland
Interests: organic synthesis; medicinal chemistry; asymmetric synthesis; organoselenium compounds
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Special Issue Information

Dear Colleagues,

Chemistry influences many areas of our everyday life and novel chemical processes are continuously being developed in order to make life easier. Innovative synthetic pathways and approaches are designed to accelerate and increase the efficiency of obtaining compounds for the medical, agrochemical, petrochemical, and manufacturing industry sectors, among others. Old reactions are constantly reinterpreted to fulfill the rules of green chemistry and the green economy. In this context, organochalcogen chemistry is worth mentioning, since its interest within a green chemistry perspective has been recently renewed. Stereospecific, stereoselective, stereoconvergent, and stereodivergent approaches are implemented to have a thorough control of the chirality throughout the chemical transformation. All of those actions are conducted based on the requirements of particular industrial sectors necessary to develop and meet the needs of the consumer. Nevertheless, starting from basic synthetic problems to specific large-scale production issues, synthetical protocols face many practical challenges. For this Special Issue, we aim at collecting innovative research articles and reviews that will present novel solutions for current problems in the field of organic synthesis, with emphasis on the preparation of new compounds and new reactions that facilitate the development and improvement in chemical biology, material sciences, nanotechnology, and medicine.

Dr. Luca Sancineto
Dr. Agata Pacula
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • synthesis
  • biological evaluation
  • chirality
  • chalcogens

Published Papers (1 paper)

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Research

10 pages, 3447 KiB  
Article
Chiral Aziridine Sulfide N(sp3),S-Ligands for Metal-Catalyzed Asymmetric Reactions
by Agata J. Pacuła-Miszewska, Anna Laskowska, Anna Kmieciak, Mariola Zielińska-Błajet, Marek P. Krzemiński and Jacek Ścianowski
Symmetry 2021, 13(3), 502; https://doi.org/10.3390/sym13030502 - 19 Mar 2021
Cited by 1 | Viewed by 1845
Abstract
A series of new bidentate N,S-ligands—aziridines containing a para-substituted phenyl sulfide group—was synthesized and evaluated in the Pd-catalyzed Tsuji–Trost reaction and addition of diethylzinc and phenylethynylzinc to benzaldehyde. A high enantiomeric ratio for the addition reactions (up to 94.2:5.8) was obtained using [...] Read more.
A series of new bidentate N,S-ligands—aziridines containing a para-substituted phenyl sulfide group—was synthesized and evaluated in the Pd-catalyzed Tsuji–Trost reaction and addition of diethylzinc and phenylethynylzinc to benzaldehyde. A high enantiomeric ratio for the addition reactions (up to 94.2:5.8) was obtained using the aziridine ligand bearing a p-nitro phenyl sulfide group. Collected results reveal a specific electronic effect that, by the presence of particular electron-donating or electron-withdrawing groups in the PhS- moiety, influences the σ-donor–metal binding and the enantioselectivity of the catalyzed reactions. Full article
(This article belongs to the Special Issue Chemistry for Life)
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