Special Issue "Health Effects of Airborne Particles, Gases and Aerosols: Current and Future Perspectives"
Deadline for manuscript submissions: closed (15 November 2017)
Prof. Teresa D. Tetley
Lung Cell Biology, Division of Airway Disease, National Heart and Lung Institute, Imperial College London, SW3 6LY, UK
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Phone: +44 (0) 20 759 42984
Interests: mechanisms of pulmonary inflammation and lung disease; inhalation toxicology; cardiovascular effects; airborne particles—ambient particulate air pollution and engineered nanoparticles; asbestos; cigarette smoke; microbial infection; every day and occupational exposure; bioreactivity, immunology and toxicity; cell death pathways; particle uptake and translocation; oxidative stress; TLR activation; pro-inflammatory events
The respiratory system is the primary target organ for airborne particulates, gases, and aerosols from natural and man-made sources. Although we are equipped to deal with many of these agents, there are circumstances when the usual defence mechanisms are overwhelmed, or when lung defence is already compromised, which can lead to both acute and chronic adverse health effects. An important consideration is the ever-changing nature of airborne substances, some of which are increasingly being related to respiratory symptoms, allergy and asthma, chronic obstructive pulmonary disease (COPD), fibrosis, and cancer. In addition, there is mounting evidence that inhaled toxicants can have systemic effects on the cardiovascular system, cognition, growth, and other processes.
Today, urban traffic-related air pollution is estimated to be responsible for tens of thousands of deaths in Europe and America. Rapid urbanisation in Beijing generates a dense haze that regularly exceeds government threshold guidelines, impacting on normal lifestyles. Use of novel engineered nanomaterials is exponential; we know little about their long-term health effects, hazard and risk. Cigarette smoking is declining in the West, but is rapidly increasing in countries such as Africa. The use of electronic cigarettes (e-cigarettes) to replace tobacco is perceived to be less harmful, yet they contain additives, the effects of which are largely unknown. Other considerations include the effects of climate change, natural events/disasters, therapeutic applications, spray products and use of biomass fuels.
The aim of this Special Issue is to highlight current and anticipated future issues relating to the human health effects of exposure to airborne toxicants. Of particular interest is whether what we have already learnt will impact on managing assessment of hazard and risk of exposure to new types of airborne substances and anticipated health effects of future exposures (e.g., burning biomass, new generation nanomaterials, novel inhaled therapeutics, novel consumer products/sprays). Original research papers, reviews and short communications are welcome. The following areas will be covered:
- Respiratory effects: e.g., allergy and asthma, cough, COPD, cancer, fibrosis
- Cardiovascular effects: e.g., thrombosis (associated with acute coronary syndrome, stroke, deep venous thrombosis) and electrical dysfunction (ventricular arrhythmia) and changes in autonomic nervous system
- Impact on other organs following inhalation, e.g., brain/cognitive function, growth, nervous system
- Multipollutant exposure
- Epidemiological evidence
- Physiological impacts
- Cellular mechanisms—oxidative stress, inflammatory pathways, particle uptake and fate, cell death, mutagenesis, etc.
- Use and translational significance of existing and novel in vitro and in vivo toxicity testing models
- Modelling and dosimetry
Prof. Teresa D. Tetley
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 350 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Air pollution
- Respiratory system
- Cardiovascular system
- Nervous system
- Oxidative stress
- Inflammatory signalling pathways