Venomous Snakes: Taxonomy, Toxicology and Clinical Management of Envenomation

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1184

Special Issue Editors


E-Mail Website
Guest Editor
European Food Safety Authority (EFSA), Via Carlo Magno 1A, 43126 Parma, Italy
Interests: clinical pharmacology; toxicology; statistics

E-Mail Website
Guest Editor
Unit of Dermatology, IRCCS San Raffaele Hospital, 20132 Milan, Italy
Interests: reptiles; amphibians; herpetology; snakes; Italian wildlife
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Currently, over 4000 species of snakes have been described across all world continents except Antarctica; of these species, over 600 species are considered venomous.

Snakebites constitute a significant public health issue in both developing and developed countries, with over 5 million people being bitten every year and over 2.7 million people poisoned according to the World Health Organisation. In terms of associated mortalities, 138,000 deaths are reported on a yearly basis and a much larger number of patients are left with permanent disabilities. On a taxonomical basis, knowledge on the toxicology of snake venoms and clinical management aspects of envenomation vary from species to species and particularly depends on the geographical distribution, impact on public health and severity of the envenomation.

The present Special Issue aims to publish original research articles, reviews, and short communications on the toxinology and toxicology of snake venom and clinical management of snake envenomation. Recent investigations integrating the taxonomy, geographical distribution, and biochemical characterisation of snake toxins and clinical investigations associated with snake bites are also relevant to this Special Issue, including snake species that are not generally considered to be venomous (e.g., colubridae).

Dr. Jean Lou Dorne
Dr. Matteo Riccardo Di Nicola
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • snakebite
  • toxinology
  • toxicology
  • clinical management
  • snake envenomation
  • antivenom

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 3266 KiB  
Article
Studying Venom Toxin Variation Using Accurate Masses from Liquid Chromatography–Mass Spectrometry Coupled with Bioinformatic Tools
by Luis L. Alonso, Jory van Thiel, Julien Slagboom, Nathan Dunstan, Cassandra M. Modahl, Timothy N. W. Jackson, Saer Samanipour and Jeroen Kool
Toxins 2024, 16(4), 181; https://doi.org/10.3390/toxins16040181 - 07 Apr 2024
Viewed by 672
Abstract
This study provides a new methodology for the rapid analysis of numerous venom samples in an automated fashion. Here, we use LC-MS (Liquid Chromatography–Mass Spectrometry) for venom separation and toxin analysis at the accurate mass level combined with new in-house written bioinformatic scripts [...] Read more.
This study provides a new methodology for the rapid analysis of numerous venom samples in an automated fashion. Here, we use LC-MS (Liquid Chromatography–Mass Spectrometry) for venom separation and toxin analysis at the accurate mass level combined with new in-house written bioinformatic scripts to obtain high-throughput results. This analytical methodology was validated using 31 venoms from all members of a monophyletic clade of Australian elapids: brown snakes (Pseudonaja spp.) and taipans (Oxyuranus spp.). In a previous study, we revealed extensive venom variation within this clade, but the data was manually processed and MS peaks were integrated into a time-consuming and labour-intensive approach. By comparing the manual approach to our new automated approach, we now present a faster and more efficient pipeline for analysing venom variation. Pooled venom separations with post-column toxin fractionations were performed for subsequent high-throughput venomics to obtain toxin IDs correlating to accurate masses for all fractionated toxins. This workflow adds another dimension to the field of venom analysis by providing opportunities to rapidly perform in-depth studies on venom variation. Our pipeline opens new possibilities for studying animal venoms as evolutionary model systems and investigating venom variation to aid in the development of better antivenoms. Full article
Show Figures

Graphical abstract

Back to TopTop