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Toxins
Special Issues
Application of Botulinum Toxins in Non-spastic and Neurodegenerative Disorders
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Application of Botulinum Toxins in Non-spastic and Neurodegenerative Disorders

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 4950

Special Issue Editors

Dr. Marjolaine Baude

E-Mail Website
Guest Editor
Service de Rééducation Neurolocomotrice, Henri Mondor University Hospitals, 94000 Créteil, France
Interests: neuroplasticity; neurorehabilitation; spasticity; movement disorders; neurodegenerative diseases; botulinum toxin; facial nerve injuries; facial paresis; motion capture
Prof. Dr. Jean-Michel Gracies

E-Mail Website
Guest Editor
Service de Rééducation Neurolocomotrice, Henri Mondor University Hospitals, 94000 Créteil, France
Interests: neuroplasticity; neurorehabilitation; movement disorders; spasticity; neurodegenerative diseases; botulinum toxin

Special Issue Information

Dear Colleagues,

In recent years, botulinum toxins (BoNT), beyond their massive use in conditions involving spastic muscle overactivity, have been used for the treatment of a large number of other medical indications, including the treatment of non-spastic motor and non-motor disorders. Many of the symptoms or syndromes for which BoNT has been found to be effective occur in a variety of neurological conditions, including neurodegenerative disorders. Botulinum toxins are highly potent biotoxins that can partially block nerve signals to muscles or other effectors. Suited doses make them potentially powerful therapeutic tools for excessive muscle contractions or autonomic dysfunctions.

This Special Issue will provide discussions on the application and development of botulinum toxins in the treatment of non-spastic motor and non-motor symptoms, particularly in the context of neurodegenerative diseases. Submissions can include reviews, systematic reviews, and meta-analyses, as well as original studies.

Dr. Marjolaine Baude
Prof. Dr. Jean-Michel Gracies
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • botulinum toxin
  • non-spastic neurologic disorders
  • neurodegenerative disorders
  • parkinsonian syndromes
  • idiopathic parkinson’s disease
  • tremors
  • facial paresis

Published Papers (2 papers)

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Research

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14 pages, 1259 KiB  
Article
Long-Term Muscular Atrophy and Weakness Following Cessation of Botulinum Toxin Type A Injections in the Flexor Digitorum Muscle of Musicians with Focal Hand Dystonia
by Christos I. Ioannou, Franziska L. Hodde-Chriske and Eckart Altenmüller
Toxins 2023, 15(4), 296; https://doi.org/10.3390/toxins15040296 - 18 Apr 2023
Cited by 2 | Viewed by 3231
Abstract
The present study assessed muscular atrophy and weakness of the flexor digitorum superficialis (FDS) and profundus (FDP) muscle as possible long-term side effects of botulinum toxin (BoNT) injections in hand dystonia patients after the termination of their treatment. For the assessment of both [...] Read more.
The present study assessed muscular atrophy and weakness of the flexor digitorum superficialis (FDS) and profundus (FDP) muscle as possible long-term side effects of botulinum toxin (BoNT) injections in hand dystonia patients after the termination of their treatment. For the assessment of both parameters, a group of 12 musicians diagnosed with focal hand dystonia was compared with a group of 12 healthy matched musicians. The minimum and maximum times since the last injection across patients were 0.5 to 3.5 years, respectively. The thickness and strength of the FDS and FDP were assessed via ultrasonography and a strength measurement device. Group differences were estimated through the calculation of the symmetry index between the dominant and non-dominant hand. The results revealed that compared to the control group, thickness and flexion strength of the injected FDS and FDP were decreased by 10.6% ± 5.3% (95% CI) and 12.5% ± 6.4% (95% CI), respectively, in the patient group. The amount of weakness and atrophy was predicted significantly by the total amount of BoNT injected throughout the entire treatment period. In contrast, the time after the last injection did not predict the amount of strength and muscle mass recovery after the cessation of the treatment. The current study revealed that even up to 3.5 years after the termination of BoNT injections, long-term side effects such as weakness and atrophy can still be observed. We suggest that the total BoNT dose should remain as small as possible to reduce long-lasting side effects to the minimum. Although side effects differ significantly among patients, a potential full recovery of atrophy and weakness after the cessation of BoNT treatment might be observed after periods longer than 3.5 years. Full article
(This article belongs to the Special Issue Application of Botulinum Toxins in Non-spastic and Neurodegenerative Disorders)
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Review

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20 pages, 2131 KiB  
Review
Botulinum Toxin Injections to Manage Sequelae of Peripheral Facial Palsy
by Fabienne Carré, Jérémy Amar, Frédéric Tankéré and Claire Foirest
Toxins 2024, 16(3), 161; https://doi.org/10.3390/toxins16030161 - 20 Mar 2024
Viewed by 1209
Abstract
Long-standing facial palsy sequelae cause functional, aesthetic, and psychological problems in patients. Botulinum toxin is an effective way to manage them, but no standardized recommendations exist. Through this non-systematic review, we aimed to guide any practitioner willing to master the ins and outs [...] Read more.
Long-standing facial palsy sequelae cause functional, aesthetic, and psychological problems in patients. Botulinum toxin is an effective way to manage them, but no standardized recommendations exist. Through this non-systematic review, we aimed to guide any practitioner willing to master the ins and outs of this activity. We reviewed the existing literature and completed, with our experience as a reference center, different strategies of botulinum toxin injections used in facial palsy patients, including history, physiopathology, facial analysis, dosages, injection sites, and techniques, as well as time intervals between injections. The reader will find all the theorical information needed to best guide injections according to the patient’s complaint, which is the most important information to consider. Full article
(This article belongs to the Special Issue Application of Botulinum Toxins in Non-spastic and Neurodegenerative Disorders)
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