Inhibition of Mycotoxin Production

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 2378

Special Issue Editors


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Guest Editor
Department of Biosciences, Faculty of Science and Engineering, Teikyo University, 1-1 Toyosatodai, Utsunomiya City, Tochigi Prefecture 320-8551, Japan
Interests: bioorganic chemistry of bioactive natural compounds
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Guest Editor
National Institute of Health Sciences, 3-25-26, Tonomachi, Kawasaki-shi, Kanagawa 210-9501, Japan
Interests: analytical methods for mycotoxin analysis

Special Issue Information

Dear Colleagues,

Mycotoxin contamination in crops causes health and economic problems worldwide. However, practical methods for mycotoxin control are lacking, and we are in dire need of developing them. Inhibition of mycotoxin production is a possible method for mycotoxin control. In this Special Issue, manuscripts that provide data on inhibition of mycotoxin production are invited. Mycotoxin production inhibitors are useful as mycotoxin control agents. They are found in a variety of sources, such as plant constituents, microbial metabolites, pesticides, food additives, and chemical libraries. Mycotoxin production inhibitors are also useful as biological probes to investigate the regulatory mechanism for mycotoxin production. Works to clarify their modes of action are important for determining the optimal target of methods to control mycotoxin contamination. Microorganisms, which inhibit mycotoxin production, are useful as biocontrol agents. Works to investigate their inhibitory mechanism are also important. All papers dealing with these objectives are welcome.

Prof. Dr. Shohei Sakuda
Dr. Tomoya Yoshinari
Guest Editors

Manuscript Submission Information

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Keywords

  • inhibition
  • inhibitors
  • inhibitory mechanism
  • biocontrol
  • microorganisms
  • mode of action

Published Papers (1 paper)

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Research

17 pages, 1436 KiB  
Article
Investigating the Efficiency of Hydroxycinnamic Acids to Inhibit the Production of Enniatins by Fusarium avenaceum and Modulate the Expression of Enniatins Biosynthetic Genes
by Charlotte Gautier, Laetitia Pinson-Gadais, Marie-Noelle Verdal-Bonnin, Christine Ducos, Judith Tremblay, Sylvain Chéreau, Vessela Atanasova and Florence Richard-Forget
Toxins 2020, 12(12), 735; https://doi.org/10.3390/toxins12120735 - 24 Nov 2020
Cited by 11 | Viewed by 1808
Abstract
Enniatins (ENNs) that belong to the group of emerging mycotoxins are widespread contaminants of agricultural commodities. There is currently insufficient evidence to rule out health concerns associated with long-term exposure to ENNs and efforts must be strengthened to define a control strategy. While [...] Read more.
Enniatins (ENNs) that belong to the group of emerging mycotoxins are widespread contaminants of agricultural commodities. There is currently insufficient evidence to rule out health concerns associated with long-term exposure to ENNs and efforts must be strengthened to define a control strategy. While the potential of plant compounds to counteract the contamination with legislated mycotoxins has been reported, little remains known regarding ENNs. The present study evidenced for the first time the efficiency of hydroxycinnamic acids to inhibit the fungal growth and ENNs yield by Fusarium avenaceum. Notably, 0.5 mM of exogenous ferulic, caffeic, and p-coumaric acids led to a drastic reduction of ENNs synthesis in pH4 broths, with ferulic acid being the most potent. The ENNs production inhibitory activity of ferulic acid was shown to be associated with a significant down-regulation of the expression of ENNs biosynthetic genes. To further investigate the bioactivity of ferulic acid, its metabolic fate was characterized in fungal broths and the capacity of F. avenaceum to metabolize it through a C2-cleavage type degradation was demonstrated. Overall, our data support the promising use of ferulic acid in ENNs control strategies, either as part of an environmentally friendly plant-care product or as a biomarker of plant resistance. Full article
(This article belongs to the Special Issue Inhibition of Mycotoxin Production)
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