Bordetella pertussis Infection and Vaccination
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Tropical and other Infectious Diseases".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 30631
Special Issue Editor
Interests: B cells; Ag-specific B cells; BCR repertoire; pertussis infection and vaccination; primary and booster vaccination; flow cytometry; molecular biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pertussis or whooping cough is an acute infection of the respiratory tract caused by the bacterium Bordetella pertussis (Bp). Despite good vaccination coverage, it remains a disease with one of the highest residual morbidity and mortality, and it is especially dangerous for infants and young children. The first vaccine against pertussis contained whole inactivated bacterium (wP). It was introduced in the 1950s and led to a significant decrease in the number of pertussis cases. Later on, it was replaced by a presumably safer acellular pertussis vaccine (aP) containing only selected pertussis proteins. This coincided with an increase in the number of pertussis cases. At present, not only is the number of pertussis cases increasing, but the Bp carriership in the human population also remains high. Several attempts have been made to improve current vaccination strategies, such as optimizing the composition of current acellular vaccines or testing alternative vaccination routes. This Special Issue of Vaccines focuses on research that aims to understand immune responses to Bp infection and vaccination, which can shed light on the high pertussis incidence and provide strategies for better pertussis management at the population level. Submissions to this Special Issue can be studies that either evaluate current pertussis vaccines or are aiming to improve them. Research in both human and animal models are welcome.
Dr. Magdalena A. Berkowska
Guest Editor
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Keywords
- pertussis
- infection
- vaccination
- serology
- cellular analysis
- human studies
- animal models
- epidemiology
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