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Vaccines
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Immunogenetics Research
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Immunogenetics Research

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Innate and Adaptive Immunity in Vaccination".

Deadline for manuscript submissions: closed (30 December 2021) | Viewed by 5820

Special Issue Editor

Prof. Dr. Sofia Kossida

E-Mail Website
Guest Editor
IMGT, The International ImMunoGeneTics Information System, National Center for Scientific Research (CNRS), Institute of Human Genetics (IGH), University of Montpellier (UM), 34090 Montpellier, France
Interests: genome analysis; immunogenetics; genetic information; vaccine development & administration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

At present, an avalanche of genomic data is being produced at an incredible pace. Making sense of this information is still a challenge. The genomes of several species, as well as the genomes of several individuals of the same species—which give us the chance to study the haplotypes and the ultimate implication of specific genes for a given phenotype, paving the way to personalized medicine—are accessible through publicly available generalist databases. High-throughput sequencing is becoming more effective, and its cost is constantly decreasing. The analysis of the immune repertoire is tightly linked to any vaccination procedure, as well as the distinction between pathological and nonpathological conditions in both basic and clinical research.

We will focus on the adaptive immune response, and in this Special Issue entitled “Immunogenetics Research” we welcome all papers, reviews, methodologies, and novel software tools able to shed new light in the immunogenetics field. More specifically, we encourage submissions on the genomic organization of the immunoglobulins (IG) and/or T cell receptors (TR) of a species, comparative analyses between/among species, immune repertoire analyses, tools to visualize the immune repertoire data, tools to analyze and integrate the data under question with several resources, and studies on ontologies in the field.

Prof. Sofia Kossida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunogenetics
  • immunoinformatics
  • immune repertoire
  • immunoglobulins
  • T-cell receptors
  • software tools
  • ontology
  • data integration
  • Artificial Intelligence
  • immunogentics

Published Papers (2 papers)

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Research

18 pages, 2661 KiB  
Article
Comparative Immunoreactivity Analyses of Hantaan Virus Glycoprotein-Derived MHC-I Epitopes in Vaccination
by Baozeng Sun, Junqi Zhang, Jiawei Wang, Yang Liu, Hao Sun, Zhenhua Lu, Longyu Chen, Xushen Ding, Jingyu Pan, Chenchen Hu, Shuya Yang, Dongbo Jiang and Kun Yang
Vaccines 2022, 10(4), 564; https://doi.org/10.3390/vaccines10040564 - 6 Apr 2022
Cited by 3 | Viewed by 2125
Abstract
MHC-I antigen processes and presentation trigger host-specific anti-viral cellular responses during infection, in which epitope-recognizing cytotoxic T lymphocytes eliminate infected cells and contribute to viral clearance through a cytolytic killing effect. In this study, Hantaan virus (HTNV) GP-derived 9-mer dominant epitopes were obtained [...] Read more.
MHC-I antigen processes and presentation trigger host-specific anti-viral cellular responses during infection, in which epitope-recognizing cytotoxic T lymphocytes eliminate infected cells and contribute to viral clearance through a cytolytic killing effect. In this study, Hantaan virus (HTNV) GP-derived 9-mer dominant epitopes were obtained with high affinity to major HLA-I and H-2 superfamilies. Further immunogenicity and conservation analyses selected 11 promising candidates, and molecule docking (MD) was then simulated with the corresponding MHC-I alleles. Two-way hierarchical clustering revealed the interactions between GP peptides and MHC-I haplotypes. Briefly, epitope hotspots sharing good affinity to a wide spectrum of MHC-I molecules highlighted the biomedical practice for vaccination, and haplotype clusters represented the similarities among individuals during T-cell response establishment. Cross-validation proved the patterns observed through both MD simulation and public data integration. Lastly, 148 HTNV variants yielded six types of major amino acid residue replacements involving four in nine hotspots, which minimally influenced the general potential of MHC-I superfamily presentation. Altogether, our work comprehensively evaluates the pan-MHC-I immunoreactivity of HTNV GP through a state-of-the-art workflow in light of comparative immunology, acknowledges present discoveries, and offers guidance for ongoing HTNV vaccine pursuit. Full article
(This article belongs to the Special Issue Immunogenetics Research)
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32 pages, 36754 KiB  
Article
IMGT® Biocuration and Analysis of the Rhesus Monkey IG Loci
by Viviane Nguefack Ngoune, Morgane Bertignac, Maria Georga, Ariadni Papadaki, Alexandre Albani, Géraldine Folch, Joumana Jabado-Michaloud, Véronique Giudicelli, Patrice Duroux, Marie-Paule Lefranc and Sofia Kossida
Vaccines 2022, 10(3), 394; https://doi.org/10.3390/vaccines10030394 - 3 Mar 2022
Cited by 3 | Viewed by 2897
Abstract
The adaptive immune system, along with the innate immune system, are the two main biological processes that protect an organism from pathogens. The adaptive immune system is characterized by the specificity and extreme diversity of its antigen receptors. These antigen receptors are the [...] Read more.
The adaptive immune system, along with the innate immune system, are the two main biological processes that protect an organism from pathogens. The adaptive immune system is characterized by the specificity and extreme diversity of its antigen receptors. These antigen receptors are the immunoglobulins (IG) or antibodies of the B cells and the T cell receptors (TR) of the T cells. The IG are proteins that have a dual role in immunity: they recognize antigens and trigger elimination mechanisms, to rid the body of foreign cells. The synthesis of the immunoglobulin heavy and light chains requires gene rearrangements at the DNA level in the IGH, IGK, and IGL loci. The rhesus monkey (Macaca mulatta) is one of the most widely used nonhuman primate species in biomedical research. In this manuscript, we provide a thorough analysis of the three IG loci of the Mmul_10 assembly of rhesus monkey, integrating IMGT previously existing data. Detailed characterization of IG genes includes their localization and position in the loci, the determination of the allele functionality, and the description of the regulatory elements of their promoters as well as the sequences of the conventional recombination signals (RS). This complete annotation of the genomic IG loci of Mmul_10 assembly and the highly detailed IG gene characterization could be used as a model, in additional rhesus monkey assemblies, for the analysis of the IG allelic polymorphism and structural variation, which have been described in rhesus monkeys. Full article
(This article belongs to the Special Issue Immunogenetics Research)
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