HPV Immunotherapy

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Human Papillomavirus Vaccines".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3238

Special Issue Editor


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Guest Editor
Center for Advanced Studies and Technology, Department of Medical, Oral and Biotechnology Science, “G. d’Annunzio” University of Chieti – Pescara, Chieti, Italy
Interests: inflammation; resolution; resolvins; lipoxins; oncoviruses; hpv; autophagy; neutrophils; macrophages; cystic fibrosis; chronic inflammation
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Special Issue Information

Dear Colleagues,

Infection with high-risk human papilloma viruses (HPV) is the causative agent of cervical cancer and is associated with other anogenital malignancies and head and neck cancers. Novel therapeutic approaches to control HPV cancers are of wide interest since, despite the implementation of an effective vaccination program, HPV cancer burden is still very high.

Immunotherapy aimed at strengthening the host immune system response against tumor cells has shown promise in HPV malignancies. However, benefits are limited for some patients, urging more efforts in this area.

The focus of this Research Topic is to collect articles, reviews or case reports covering different aspects of HPV cancers and immunology that shed light on potential innovative therapeutic options, such as, but not limited to:

  • Immunotherapy and delivery systems;
  • Tumor/immune system crosstalk;
  • Strategies to re-educate immune cells;
  • Biomarkers to follow and predict response to immune therapies.

Dr. Domenico Mattoscio
Guest Editor

Manuscript Submission Information

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Keywords

  • HPV cancers
  • Cervical cancer
  • Head and neck cancer
  • HPV vaccines
  • HPV immunotherapy
  • Immune checkpoint inhibitors
  • T-cell transfer therapy
  • Monoclonal antibodies
  • Immune system modulators
  • Immune cells
  • Innate and adaptive immune response
  • Biomarkers
  • Tumor-host interaction
  • Tumor microenvironment

Published Papers (1 paper)

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Research

11 pages, 4797 KiB  
Article
Predictors of the Therapeutic Response to Intralesional Bivalent HPV Vaccine in Wart Immunotherapy
by Noha M. Hammad, Ayman Marei, Gamal El-Didamony, Zeinb Mortada, Mona Elradi, Amira Hamed Mohamed Afifi and Heba M. Kadry
Vaccines 2021, 9(11), 1280; https://doi.org/10.3390/vaccines9111280 - 4 Nov 2021
Cited by 1 | Viewed by 2642
Abstract
Variable intralesional immunotherapies have recently been proposed as a means of achieving a successful eradication of recurrent and recalcitrant human papillomavirus (HPV)-induced cutaneous and anogenital warts. The bivalent HPV vaccine is one of the newly proposed immunotherapeutic agents. We investigated the role of [...] Read more.
Variable intralesional immunotherapies have recently been proposed as a means of achieving a successful eradication of recurrent and recalcitrant human papillomavirus (HPV)-induced cutaneous and anogenital warts. The bivalent HPV vaccine is one of the newly proposed immunotherapeutic agents. We investigated the role of interleukin-4 (IL-4) and interferon-gamma (IFN-γ) as ex vivo immunologic predictors to estimate the response to the bivalent HPV vaccine as a potential immunotherapy for cutaneous and anogenital warts. Heparinized blood samples were withdrawn from forty patients with multiple recurrent recalcitrant cutaneous and anogenital warts and forty matched healthy control subjects. Whole blood cultures were prepared with and without bivalent HPV vaccine stimulation. Culture supernatants were harvested and stored for IL-4 and IFN-γ measurements using an enzyme-linked immunosorbent assay. A comparative analysis of IL-4 and IFN-γ levels in culture supernatants revealed a non-significant change between the patient and control groups. The bivalent HPV vaccine stimulated cultures exhibited a non-significant reduction in IL-4 levels within both groups. IFN-γ was markedly induced in both groups in response to bivalent HPV vaccine stimulation. The bivalent HPV vaccine can give a sensitive IFN-γ immune response ex vivo, superior to IL-4 and sufficient to predict both the successful eradication of HPV infection and the ultimate clearance of cutaneous and anogenital warts when the bivalent HPV vaccine immunotherapy is applied. Full article
(This article belongs to the Special Issue HPV Immunotherapy)
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