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Vaccines
Special Issues
Veterinary Parasitic Vaccines: Current Status and Future Directions
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Veterinary Parasitic Vaccines: Current Status and Future Directions

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 6180

Special Issue Editors

Dr. Monica Leszkowicz Mazuz

E-Mail Website
Guest Editor
Parasitology Division, Kimron Veterinary Institute, Israeli Veterinary Services and Animal Health, Beith Dagan 50250, Israel
Interests: veterinary parasitology; protozoology; ticks; tick-borne diseases; veterinary epidemiology; vaccine development; parasite diagnostics
Dr. Carlos E. Suarez

E-Mail Website
Guest Editor
Animal Disease Research Unit, ARS-USDA, and Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-6630, USA
Interests: ticks and tick-borne diseases of livestock; vaccine development and molecular biology of apicomplexan parasites; diagnostics of babesiosis in livestock
Special Issues, Collections and Topics in MDPI journals
Dr. Sharon Tirosh-Levy

E-Mail Website
Guest Editor
Kimron Veterinary Institute Israel, Bet Dagan, Israel
Interests: veterinary parasitology; equine medicine; epidemiology of infectious diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Veterinary parasitic diseases are caused by a range of parasites, with major impacts on animal health and productivity, causing severe economic losses in livestock. The causative agents of parasitic diseases include protozoa, helminths and ectoparasites, which require different prevention and control strategies.

Parasites use complex mechanisms, including antigenic variation, to escape host immune responses, which may lead to immune modulation and result in long-term persistent infections. Therefore, the control of parasitic diseases is challenging and usually requires advanced diagnostics and integrated control measures including chemotherapy, vaccines and management. 

This Special Issue, “Veterinary Parasitic Vaccines: Current Status and Future Directions”, aims to gather knowledge concerning the use of currently available vaccines (drawbacks and advantages) and future trends in the development of vaccines against protozoa, helminths and ectoparasites. Thus, all manuscripts related to parasitic vaccine development (new approaches), epidemiological data for current and forthcoming vaccines, clinical trials, disease outbreaks, parasites’ immune responses, antigenic variation, host/parasite interactions, DIVA diagnostics, adjuvants and vectored vaccines, and general research on traditional and novel parasitic diseases will be welcomed. 

Dr. Monica Leszkowicz Mazuz
Dr. Carlos E. Suarez
Dr. Sharon Tirosh-Levy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • parasites
  • protozoa
  • tick-borne diseases
  • helminths
  • ectoparasites
  • vaccine
  • host/parasite infection
  • epidemiology

Published Papers (2 papers)

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Research

18 pages, 7721 KiB  
Article
Protective Immunization of Atlantic Salmon (Salmo salar L.) against Salmon Lice (Lepeophtheirus salmonis) Infestation
by Haitham Tartor, Marius Karlsen, Rasmus Skern-Mauritzen, Adérito Luis Monjane, Charles McLean Press, Christer Wiik-Nielsen, Rolf Hetlelid Olsen, Lisa Marie Leknes, Karine Yttredal, Bjørn Erik Brudeseth and Søren Grove
Vaccines 2022, 10(1), 16; https://doi.org/10.3390/vaccines10010016 - 23 Dec 2021
Cited by 5 | Viewed by 3206
Abstract
Vaccination against salmon lice (Lepeophtheirus salmonis) is a means of control that averts the negative effects of chemical approaches. Here, we studied the immunogenicity and protective effect of a vaccine formulation (based on a salmon lice-gut recombinant protein [P33]) against Lepeophtheirus [...] Read more.
Vaccination against salmon lice (Lepeophtheirus salmonis) is a means of control that averts the negative effects of chemical approaches. Here, we studied the immunogenicity and protective effect of a vaccine formulation (based on a salmon lice-gut recombinant protein [P33]) against Lepeophtheirus salmonis infestation in Atlantic salmon in a laboratory-based trial. Our findings revealed that P33 vaccine can provide a measure of protection against immature and adult salmon lice infestation. This protection seemed to be vaccine dose-dependent, where higher doses resulted in lower parasitic infestation rates. We also provide immunological evidence confirming that P33-specific immune response can be triggered in Atlantic salmon after P33 vaccination, and that production of P33-specific antibodies in blood can be detected in vaccinated fish. The negative correlation between P33-specific IgM in salmon plasma and salmon lice numbers on vaccinated fish suggests that protection against lice can be mediated by the specific antibody in salmon plasma. The success of P33 vaccination in protecting salmon against lice confirms the possibility of employing the hematophagous nature of the parasite to deliver salmon-specific antibodies against lice-gut proteins. Full article
(This article belongs to the Special Issue Veterinary Parasitic Vaccines: Current Status and Future Directions)
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11 pages, 730 KiB  
Article
The Effect of Vaccination with Neospora caninum Live-Frozen Tachyzoites on Abortion Rates of Naturally Infected Pregnant Cows
by Monica L. Mazuz, Benjamin Leibovitz, Igor Savitsky, Elena Blinder, Daniel Yasur-Landau, Yaniv Lavon, Binyamin Sharir and Sharon Tirosh-Levy
Vaccines 2021, 9(4), 401; https://doi.org/10.3390/vaccines9040401 - 19 Apr 2021
Cited by 8 | Viewed by 2153
Abstract
Neosporosis is a major cause of abortions in cattle worldwide. Recently a live attenuated vaccine showing promising results in preventing abortions, when administered at mid-pregnancy to seropositive cows, was developed. In this study, vaccination with 2 × 108 live frozen N. caninum [...] Read more.
Neosporosis is a major cause of abortions in cattle worldwide. Recently a live attenuated vaccine showing promising results in preventing abortions, when administered at mid-pregnancy to seropositive cows, was developed. In this study, vaccination with 2 × 108 live frozen N. caninum tachyzoites (NcIs491) was used to immunize naturally infected seropositive pregnant dairy dams. The study was performed under field conditions in four herds, and a follow-up of three subsequent pregnancies was analyzed. A total of 1136 cows were serologically examined. Total seroprevalence was 41.4%, with 25.1% of the cows having titers of 1:800 or higher. Abortion rates were significantly higher in cows with high antibody titers (≥1:800) for two consecutive pregnancies. Vaccination was administered to 114 out of 285 cows with antibody titers higher than 1:800. Immunization resulted in lower abortion rates at three of the farms. Vaccine efficacy ranged from −19.8% to 75% at different farms, with overall efficacy of 28.4% in all four farms and overall efficacy of 58.2% in the three farms with positive results. Our results showed different vaccine efficacy in studied farms, suggesting that frozen live vaccination may generally be an effective method to control neosporosis in cattle. Full article
(This article belongs to the Special Issue Veterinary Parasitic Vaccines: Current Status and Future Directions)
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