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Veterinary Sciences
Special Issues
Spotlight on Tuberculosis and Mycoplasmosis in Cattle
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Spotlight on Tuberculosis and Mycoplasmosis in Cattle

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Microbiology, Parasitology and Immunology".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 3214

Special Issue Editor

Prof. Dr. Aizhen Guo

E-Mail Website
Guest Editor
College of Veterinary Medicine, The State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
Interests: cattle infectious diseases; vaccine; diagnosis; epidemiology; biosafety; zoonosis; tuberculosis; mycoplasmosis; BVDV; IBRV

Special Issue Information

Dear Colleagues,

The biggest barrier impeding the cattle industry is disease. Two troublesome diseases are bovine tuberculosis (bTB) and mycoplasmosis. bTB is globally controlled via detection slaughtering. However, the high economic burden and concept of animal protection makes the implementation of this policy very difficult. The important bovine mycoplasmas include Mycoplasma mycoides subsp. mycoides SC which cause contagious bovine pleuropneumonia (CBPP), a highly contagious and deadly infectious disease, and Mycoplasma bovis, one of the main pathogens leading to bovine respiratory disease as well as being responsible for various other diseases such as mastitis, arthritis, etc. Although eradicated in several countries, CBPP remains enzootic in many Sub-Saharan African countries. Meanwhile, Mycoplasma bovis causes worldwide economic loss in the bovine industry, mainly affecting new-born calves and milking cows after long-distance transportation. The expectation for new measures to be developed and used against bovine TB and mycoplasmosis is high. To achieve this goal, it is necessary to elucidate their epidemic rules, pathogenesis and immune responses. Therefore, we bring you this Special Issue focusing on tuberculosis and mycoplasmosis in cattle; our hope is to present the most recent progress in this area, provide valuable references to develop new strategies to control these two diseases and ultimately promote the healthy and sustainable development of the bovine industry.

Prof. Dr. Aizhen Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tuberculosis
  • mycoplasmosis
  • cattle

Published Papers (2 papers)

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Research

11 pages, 244 KiB  
Article
Individual- and Herd-Level Milk ELISA Test Status and Incidence for Paratuberculosis in Hubei Province, China
by Yingyu Chen, Liyue Hou, Abdul Karim Khalid, Ian Duncan Robertson, Yuhao Zhao, Xi Chen and Aizhen Guo
Vet. Sci. 2024, 11(5), 202; https://doi.org/10.3390/vetsci11050202 - 7 May 2024
Viewed by 437
Abstract
Mycobacterium avium subsp. paratuberculosis (MAP) is responsible for the persistent infectious illness known as bovine paratuberculosis, which is one of the most easily overlooked diseases in China amid a lack of epidemiological data. In this study, we evaluated the agreement of milk and [...] Read more.
Mycobacterium avium subsp. paratuberculosis (MAP) is responsible for the persistent infectious illness known as bovine paratuberculosis, which is one of the most easily overlooked diseases in China amid a lack of epidemiological data. In this study, we evaluated the agreement of milk and blood antibody tests for paratuberculosis and showed an overall agreement of 92.0%, with a 95.0% negative coincidence rate and a 78.6% positive coincidence rate. The milk test was then used to examine the prevalence and incidence of dairy cows in Hubei Province, China. We found that, at the individual level, the highest lacto-prevalence reached up to 22.9%; the farm-level prevalence was as high as 92.3% (12/13) and 84.6% (11/13) in January and April 2018, respectively. The total incidence risk of all farms was 6% per three months. We also found that large-scale farms had a significantly lower prevalence and incidence than small-scale farms. Finally, the correlation between paratuberculosis and milk quality was evaluated, and we confirmed that MAP can significantly alter milk quality and raise somatic cell counts in the milk. This study provides valuable information for assessing the prevalence and incidence risk of paratuberculosis in China. It further provides an essential basis for calling for the prevention and control of paratuberculosis in China. Full article
(This article belongs to the Special Issue Spotlight on Tuberculosis and Mycoplasmosis in Cattle)
13 pages, 2582 KiB  
Article
Comparative Proteomic Analysis of Secretory Proteins of Mycoplasma bovis and Mycoplasma mycoides subsp. mycoides Investigates Virulence and Discovers Important Diagnostic Biomarkers
by Ali Sobhy Dawood, Gang Zhao, Yujia He, Doukun Lu, Shujuan Wang, Hui Zhang, Yingyu Chen, Changmin Hu, Huanchun Chen, Elise Schieck and Aizhen Guo
Vet. Sci. 2023, 10(12), 685; https://doi.org/10.3390/vetsci10120685 - 1 Dec 2023
Viewed by 1785
Abstract
The most important pathogenic Mycoplasma species in bovines are Mycoplasma bovis (M. bovis) and Mycoplasma mycoides subsp. mycoides (Mmm). Mmm causes contagious bovine pleuropneumonia (CBPP), which is a severe respiratory disease widespread in sub-Saharan Africa but eradicated in several [...] Read more.
The most important pathogenic Mycoplasma species in bovines are Mycoplasma bovis (M. bovis) and Mycoplasma mycoides subsp. mycoides (Mmm). Mmm causes contagious bovine pleuropneumonia (CBPP), which is a severe respiratory disease widespread in sub-Saharan Africa but eradicated in several countries, including China. M. bovis is an important cause of the bovine respiratory disease complex (BRD), characterized worldwide by pneumonia, arthritis, and mastitis. Secreted proteins of bacteria are generally considered virulence factors because they can act as toxins, adhesins, and virulent enzymes in infection. Therefore, this study performed a comparative proteomic analysis of the secreted proteins of M. bovis and Mmm in order to find some virulence-related factors as well as discover differential diagnostic biomarkers for these bovine mycoplasmas. The secretome was extracted from both species, and liquid chromatography-tandem mass spectrometry was used, which revealed 55 unique secreted proteins of M. bovis, 44 unique secreted proteins of Mmm, and 4 homologous proteins. In the M. bovis secretome, 19 proteins were predicted to be virulence factors, while 4 putative virulence factors were identified in the Mmm secretome. In addition, five unique secreted proteins of Mmm were expressed and purified, and their antigenicity was confirmed by Western blotting assay and indirect ELISA. Among them, Ts1133 and Ts0085 were verified as potential candidates for distinguishing Mmm infection from M. bovis infection. Full article
(This article belongs to the Special Issue Spotlight on Tuberculosis and Mycoplasmosis in Cattle)
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