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Veterinary Sciences
Special Issues
Minimizing Anesthetic Risks in Dogs and Cats
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Minimizing Anesthetic Risks in Dogs and Cats

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: 15 October 2024 | Viewed by 3114

Special Issue Editor

Dr. David Orlando Alves Ferreira

E-Mail Website1 Website2
Guest Editor
Comprehensive Health Research Centre (CHRC), Departamento de Desporto e Saúde, Escola de Saúde e Desenvolvimento Humano, Universidade de Évora, Largo dos Colegiais, 7004-516 Évora, Portugal
Interests: pain management; veterinary anesthesia; monitoring anesthetic depth; veterinary anatomy; companion animal surgery

Special Issue Information

Dear Colleagues,

During anesthetic procedures, there is a constant risk associated with anesthetic protocols and its physiologic effects, namely in cardiovascular and brain functions. An understanding of perioperative monitoring and drug delivery systems, as well as the pharmacokinetic/pharmacodynamic characteristics of anesthetics drugs, largely contributes to increasing anesthetic safety and animal wellbeing, not only during the anesthetic procedures, but also in short- and long-term post-operative periods. Moreover, pain is an unavoidable variable when discussing animal comfort and anesthetic safety.

We invite you to submit scientific reports, sharing your practical experiences and clinical works, contributing to increasing anesthetic safety and animal comfort.

Dr. David Orlando Alves Ferreira
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pain
  • anaesthetic monitoring
  • analgesics
  • anaesthetics
  • opioids
  • total intravenous anaesthesia
  • constant infusion rates

Published Papers (2 papers)

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Research

17 pages, 552 KiB  
Article
The Effect of a Subsequent Dose of Dexmedetomidine or Other Sedatives following an Initial Dose of Dexmedetomidine on Sedation and Quality of Recovery in Cats: Part I
by Chrysoula Margeti, Georgios Kazakos, Vassilis Skampardonis, Apostolos D. Galatos, Theodora Zacharopoulou, Vassiliki Tsioli, Epameinondas Loukopoulos, Panagiota Tyrnenopoulou, Vasileios G. Papatsiros and Eugenia Flouraki
Vet. Sci. 2024, 11(5), 186; https://doi.org/10.3390/vetsci11050186 - 25 Apr 2024
Viewed by 433
Abstract
Dexmedetomidine is an a2-agonist commonly used in veterinary practice. Occasionally, the administered dose of dexmedetomidine may result in insufficient sedation, and an additional dose or drug may be required. The sedative effects of seven different drugs administered at subsequent time points [...] Read more.
Dexmedetomidine is an a2-agonist commonly used in veterinary practice. Occasionally, the administered dose of dexmedetomidine may result in insufficient sedation, and an additional dose or drug may be required. The sedative effects of seven different drugs administered at subsequent time points after an initial, insufficient dose of dexmedetomidine were evaluated. Seven adult cats participated in this crossover, blind, randomised study. The groups consisted of two consecutive doses of dexmedetomidine (15 + 10 μg/kg) (DD) or a dose of dexmedetomidine (15 μg/kg) followed by either NS 0.9% (DC-control group), tramadol 2 mg/kg (DT), butorphanol 0.2 mg/kg (DBT), buprenorphine 20 μg/kg (DBP), ketamine 2 mg/kg (DK), or midazolam 0.1 mg/kg (DM). Sedation was evaluated using the Grint sedation scale. In all groups, atipamezole was administered at the end of the evaluation, and recovery was assessed using the Lozano and Sams recovery scales. The DC and DM groups exhibited minimal sedative effects. The maximum sedative effect was observed in the DD and DK groups, while sedation in the DD and DK groups was significantly higher compared to the DC group. Recovery in all groups was uneventful, except in the DM group, where it was prolonged and difficult, although no statistically significant difference was detected. Therefore, insufficient sedation with dexmedetomidine can be enhanced by a subsequent dose of dexmedetomidine, ketamine, or butorphanol, whereas the addition of midazolam reduces sedation and prolongs recovery. Full article
(This article belongs to the Special Issue Minimizing Anesthetic Risks in Dogs and Cats)
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20 pages, 1362 KiB  
Article
The Effect of a Subsequent Dose of Dexmedetomidine or Other Sedatives following an Initial Dose of Dexmedetomidine on Electrolytes, Acid–Base Balance, Creatinine, Glucose, and Cardiac Troponin I in Cats: Part II
by Chrysoula Margeti, Georgios Kazakos, Apostolos D. Galatos, Vassilis Skampardonis, Theodora Zacharopoulou, Vassiliki Tsioli, Panagiota Tyrnenopoulou, Epameinondas Loukopoulos, Vasileios G. Papatsiros and Eugenia Flouraki
Vet. Sci. 2024, 11(4), 143; https://doi.org/10.3390/vetsci11040143 - 22 Mar 2024
Viewed by 1634
Abstract
The administered dose of dexmedetomidine may occasionally fail to produce the anticipated sedative effects. Therefore, a subsequent dose or administration of another sedative may enhance sedation; however, patient safety may be affected. The safety of seven different drugs administered at the following time [...] Read more.
The administered dose of dexmedetomidine may occasionally fail to produce the anticipated sedative effects. Therefore, a subsequent dose or administration of another sedative may enhance sedation; however, patient safety may be affected. The safety of seven different drugs administered at the following time point after an insufficient dose of dexmedetomidine was evaluated in a crossover, blind, experimental study that included six healthy adult cats. All cats received an initial dose of dexmedetomidine and a subsequent dose of either dexmedetomidine (Group DD), NS 0.9% (DC), tramadol (DT), butorphanol (DBT), buprenorphine (DBP), ketamine (DK), or midazolam (DM). Animal safety was assessed using repeated blood gas analysis and measurement of electrolytes, glucose, cardiac troponin I, and creatinine to evaluate cardiac, respiratory, and renal function. The median values of creatinine, cardiac troponin I, pH, partial pressure of carbon dioxide, potassium, and sodium did not change significantly throughout the study. Heart rate was significantly decreased in all groups after administration of the drug combinations, except for in the DK group. Respiratory rate decreased significantly after administration of the initial dose of dexmedetomidine and in the DBP and DM groups. The partial pressure of oxygen, although normal, decreased significantly after the administration of dexmedetomidine, whereas the median concentration of glucose increased significantly following the administration of dexmedetomidine. The results of our study suggest that the drug combinations used did not alter the blood parameters above normal limits, while cardiac and renal function were not compromised. Therefore, a safe level of sedation was achieved. However, the administration of dexmedetomidine reduced the partial pressure of oxygen; thus, oxygen supplementation during sedation may be advantageous. Additionally, the increase in glucose concentration indicates that dexmedetomidine should not be used in cats with hyperglycaemia, whereas the decrease in haematocrit suggests that dexmedetomidine is not recommended in anaemic cats. Full article
(This article belongs to the Special Issue Minimizing Anesthetic Risks in Dogs and Cats)
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