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Veterinary Sciences
Special Issues
New Insights into Pancreatic Diseases in Animals
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New Insights into Pancreatic Diseases in Animals

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Internal Medicine".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 13845

Special Issue Editor

Dr. Floryne O. Buishand

E-Mail Website
Guest Editor
Queen Mother Hospital for Animals, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
Interests: insulinoma; cancer stem cells; endocrine oncology; small animal soft tissue surgery; surgical oncology; cancer genomics; comparative oncology

Special Issue Information

Dear Colleagues,

The pancreas is a complex glandular organ in the cranial abdomen that has both endocrine and exocrine functions. Disorders of the pancreas are a major health issue for veterinary and human patients. Pancreatic diseases include acute and chronic pancreatitis, exocrine pancreatic insufficiency, diabetes mellitus, as well as pancreatic cancers with insulinoma being the most common type.

This Special Issue aims to publish original research work, reviews or case reports that provide readers with an update on the most recent advances in pancreatic disease research and management in animals. Examples of manuscript topics that will be considered are:

  • New insights into molecular pathogenesis;
  • Advances in diagnostic tests and imaging;
  • Novel (prognostic) biomarkers;
  • Novel treatment strategies;
  • Comparative aspects of pancreatic disorders in the context of “One Health”.

This Special Issue will provide the latest information on the above topics and will be of interest to those scientists and clinicians working in the area of pancreatic diseases.

Dr. Floryne O. Buishand
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pancreatitis
  • diabetes mellitus
  • pancreatic abscess
  • insulinoma
  • pancreatic adenocarcinoma
  • exocrine pancreatic insufficiency
  • molecular pathogenesis
  • biomarkers
  • treatment
  • “One Health”

Published Papers (2 papers)

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Research

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13 pages, 1673 KiB  
Article
Accuracy of 1,2-o-Dilauryl-rac-glycero-3-glutaric Acid-(6′-methylresorufin) Ester (DGGR)-Lipase to Predict Canine Pancreas-Specific Lipase (cPL) and Diagnostic Accuracy of Both Tests for Canine Acute Pancreatitis
by Lina A. Wolfer, Judith Howard and Laureen M. Peters
Vet. Sci. 2022, 9(4), 177; https://doi.org/10.3390/vetsci9040177 - 8 Apr 2022
Cited by 5 | Viewed by 4453
Abstract
Different lipase assays have variable reported diagnostic accuracies for acute pancreatitis (AP) in dogs. The aims of this retrospective study were to evaluate optimal cutoffs for 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR)-lipase to predict diagnostic cutoffs of canine pancreas-specific lipase (cPL; IDEXX). DGGR-lipase activity and [...] Read more.
Different lipase assays have variable reported diagnostic accuracies for acute pancreatitis (AP) in dogs. The aims of this retrospective study were to evaluate optimal cutoffs for 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR)-lipase to predict diagnostic cutoffs of canine pancreas-specific lipase (cPL; IDEXX). DGGR-lipase activity and cPL from the same blood draw in 301 dogs with a variety of diseases were compared using Spearman’s rank correlation, Cohen’s kappa agreement, and receiver operating characteristic (ROC) curves. Activity of DGGR-lipase (10–15,616 U/L) and cPL concentrations (8.1–≥2000 µg/L) were highly correlated (rs = 0.91). Areas under the ROC curves (AUCs) to predict cPL >200 and ≥400 µg/L with DGGR-lipase were 0.97 and 0.99, with optimal cutoffs of 143 U/L (sensitivity (Se) 91.7%; specificity (Sp) 95.3%) and 205 U/L (Se 97.5%; Sp 96.4%), and Cohen’s kappa agreements of 0.87 and 0.92, respectively. AUCs for a clinical diagnosis of AP, assigned to 87/301 dogs, with DGGR-lipase (0.75) and cPL (0.76) did not differ significantly (p = 0.48); optimal cutoffs were 161 U/L for DGGR (Se 67%; Sp 81%) and 235 µg/L for cPL (Se 68%; Sp 84%). To conclude, DGGR-lipase is a highly accurate predictor of cPL with a comparable performance when used to diagnose AP in dogs. Full article
(This article belongs to the Special Issue New Insights into Pancreatic Diseases in Animals)
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Review

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12 pages, 289 KiB  
Review
Current Trends in Diagnosis, Treatment and Prognosis of Canine Insulinoma
by Floryne O. Buishand
Vet. Sci. 2022, 9(10), 540; https://doi.org/10.3390/vetsci9100540 - 29 Sep 2022
Cited by 5 | Viewed by 8594
Abstract
The most common pancreatic tumour in dogs is the insulinoma. Canine insulinomas are considered to be malignant in more than 95% of the cases because they almost always tend to metastasise. The diagnosis of an insulinoma requires the demonstration of the simultaneous occurrence [...] Read more.
The most common pancreatic tumour in dogs is the insulinoma. Canine insulinomas are considered to be malignant in more than 95% of the cases because they almost always tend to metastasise. The diagnosis of an insulinoma requires the demonstration of the simultaneous occurrence of hypoglycaemia and blood insulin levels that are within or above the high end of the reference interval. The staging of canine insulinomas is preferably conducted by contrast-enhanced computed tomography. In general, surgical treatment is the most effective because of it results in long survival times, but many dogs also require medical treatment at some point. The prognosis of canine insulinomas is guarded as clinical hypoglycaemia almost always returns due to metastasis or tumour regrowth. This review aims to provide a summary and update the current recommendations in the veterinary literature for the diagnosis, treatment and prognostication of canine insulinomas. Full article
(This article belongs to the Special Issue New Insights into Pancreatic Diseases in Animals)
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