Special Issue "Humoral Responses Against HCV"


A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: closed (30 April 2014)

Special Issue Editor

Guest Editor
Dr. François-Loïc Cosset

Human Virology Department, Inserm U758 - Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon, Cedex 07, France
Website: http://cvscience.aviesan.fr/cv/883/francois-loic-cosset
Fax: +33 472 72 81 37
Interests: properties of the viral surface glycoproteins derived from retroviruses; flaviviruses; hepaciviruses and influenza viruses; development of novel gene transfer vectors and viral engineering techniques

Special Issue Information

Dear Colleagues,

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease world-wide. With 180 million persistently infected people chronic hepatitis C infection represents a major public health problem of high socio-economic impact. Treatment options for chronic hepatitis C are limited and a vaccine for prevention against HCV infection is not available. The investigation of the humoral response against HCV and therefore the development of potent B cell immunogens, that have greatly suffered from the paucity of HCV in vitro infection assays, is essential. Owing to recent essential progresses in the field,  the current limitations in vaccine development should be overcome by addressing the improvement of B cell responses. This should be achieved by a thorough investigation: i) of mechanisms of neutralization or escape from neutralizing antibodies, ii) of influence of serum factors - e.g., lipoproteins - that can modulate and/or counteract both cell entry and neutralization and iii) of cell entry steps that can potentially be targeted by antibodies, including those that are not raised naturally. Identifying successful immune responses against HCV and those naturally occurring in individuals spontaneously clearing infection might guide efforts to elicit such immune responses by appropriate vaccination and to produce effective neutralizing antibodies for passive immunization.

Dr. François-Loïc Cosset
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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  • hepatitis C virus
  • neutralizing antibody
  • immune correlates
  • therapy
  • monoclonals
  • viral cell entry
  • antivirals and viral escape
  • vaccines

Published Papers (3 papers)

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Displaying article 1-3
p. 2280-2300
by ,  and
Viruses 2011, 3(11), 2280-2300; doi:10.3390/v3112280
Received: 8 September 2011 / Revised: 28 October 2011 / Accepted: 7 November 2011 / Published: 15 November 2011
Show/Hide Abstract | Cited by 34 | PDF Full-text (274 KB)
(This article belongs to the Special Issue Humoral Responses Against HCV)
p. 2127-2145
by ,  and
Viruses 2011, 3(11), 2127-2145; doi:10.3390/v3112127
Received: 14 September 2011 / Revised: 18 October 2011 / Accepted: 22 October 2011 / Published: 2 November 2011
Show/Hide Abstract | Cited by 31 | PDF Full-text (1823 KB)
(This article belongs to the Special Issue Humoral Responses Against HCV)
p. 1909-1932
by ,  and
Viruses 2011, 3(10), 1909-1932; doi:10.3390/v3101909
Received: 27 July 2011 / Revised: 28 September 2011 / Accepted: 1 October 2011 / Published: 14 October 2011
Show/Hide Abstract | Cited by 32 | PDF Full-text (425 KB)
(This article belongs to the Special Issue Humoral Responses Against HCV)
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Last update: 23 October 2013

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