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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Understanding Viral Pathogenesis and Host Immune Responses to Arboviruses and Respiratory Viruses

edited by

Laura Beatriz Talarico

and

Claudia Filomatori

submission deadline 30 Jun 2026 | 10 articles | Viewed by 15339 | Submission Open

Keywords: arboviruses; respiratory viruses; viral pathogenesis; host immune responses; innate immunity; adaptive immunity; viral immune evasion; cytokine storm; interferon response; viral replication; viral transmission; immunopathology; neutralizing antibodies; host– virus interactions

(This special issue belongs to the Section Animal Viruses)

Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition

edited by

Alberto Borghetti

submission deadline 30 Jun 2026 | 7 articles | Viewed by 13469 | Submission Open

Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure

(This special issue belongs to the Section Human Virology and Viral Diseases)

An Update on Enterovirus Research, 2nd Edition

edited by

Benjamin M. Liu

submission deadline 30 Jun 2026 | 7 articles | Viewed by 13180 | Submission Open

Keywords: antivirals; enteroviruses; picornavirus; diagnostics; emerging and re-emerging diseases; viral proteins; virus replication; viral targets; virus– host interactions; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Zoonotic Viral Diseases: Drivers, Causes, Prevention and Cure, 2nd Edition

edited by

Claude Saegerman

submission deadline 30 Jun 2026 | 5 articles | Viewed by 13044 | Submission Open

Keywords: zoonotic viral diseases; drivers of emergence; disease mechanism and pathogenesis in reservoir host and end host; prevention mitigation measures; treatment

(This special issue belongs to the Section Animal Viruses)

Severe Fever with Thrombocytopenia Syndrome Virus 2026

edited by

Masayuki Saijo

submission deadline 30 Jun 2026 | 6 articles | Viewed by 12834 | Submission Open

Keywords: SFTS; SFTSV; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: 2nd Edition

edited by

Christopher U. T. Hellen

submission deadline 30 Jun 2026 | 6 articles | Viewed by 12577 | Submission Open

Keywords: virus– host interactions; IRES elements; RNA structure; translation initiation; translational control; innate immune response; RNA modification

(This special issue belongs to the Section General Virology)

Emerging Microbes, Infections and Spillovers, 2nd Edition

edited by

Ravi Kant

Tarja Sironen

and

Maciej Grzybek

submission deadline 30 Jun 2026 | 4 articles | Viewed by 9241 | Submission Open

Keywords: emerging infections; virus spillovers; microbes; cross-species transmission; virus evolution; viral disease; virus reservoirs; virus– host interaction; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Viral Hemorrhagic Disease

edited by Joseph W. Golden and Aura R. Garrison

submission deadline 30 Jun 2026 | 4 articles | Viewed by 8589 | Submission Open

Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses

(This special issue belongs to the Section Animal Viruses)

Molecular Virus–Insect Interactions, 2nd Edition

edited by Li-Long Pan

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7758 | Submission Open

Keywords: plant virus-insect vector interactions; virus transmission; entomopathogenic virus-insect host interactions; insect-specific viruses; induction and suppression of immune responses

(This special issue belongs to the Section Invertebrate Viruses)

Immune Responses to Papillomavirus Infections: 2nd Edition

edited by

Jiafen Hu

submission deadline 30 Jun 2026 | 3 articles | Viewed by 7644 | Submission Open

Keywords: papillomavirus; HPV; immune responses; infections; models

(This special issue belongs to the Section Human Virology and Viral Diseases)

Animal Virus Discovery and Genetic Diversity: 2nd Edition

edited by

Ryan Troyer

submission deadline 30 Jun 2026 | 6 articles | Viewed by 7470 | Submission Open

Keywords: animal virus; evolution; genetic; diversity; richness; emerging viruses; virome; metagenomics; ecology; cross-species transmission; zoonotic

(This special issue belongs to the Section Animal Viruses)

Oncogenic Infections and Cancer: Clinical Insights and Emerging Therapeutics

edited by G. Hossein Ashrafi and Mustafa Ozdogan

submission deadline 30 Jun 2026 | 5 articles | Viewed by 7409 | Submission Open

Keywords: oncogenesis; viral oncology; bacterial oncogenesis; human papillomavirus (HPV); Epstein– Barr virus (EBV); Kaposi’ s sarcoma-associated herpesvirus (KSHV); hepatitis B virus (HBV); hepatitis C virus (HCV); human T-lymphotropic virus (HTLV-1); Helicobacter pylori; infection-driven cancers; molecular mechanisms; tumor microenvironment; immunotherapy; viral persistence; antiviral therapies; CRISPR-based treatments; cancer prevention; vaccine development; immune checkpoint inhibitors; diagnostic biomarkers; personalized medicine; translational oncology; therapeutic resistance; emerging therapeutics

(This special issue belongs to the Section Human Virology and Viral Diseases)

ASFV Countermeasures, Pathogenesis, and Epidemiology

edited by Douglas Gladue

submission deadline 30 Jun 2026 | 6 articles | Viewed by 7106 | Submission Open

Keywords: ASF; african swine fever; swine; countermeasures; therapeutics; pathogenesis and epidemiology

(This special issue belongs to the Section Animal Viruses)

Navigating Viral Threats: Enteric and Respiratory Viral Challenges in the Post-COVID-19 Era

edited by Ahmed Mostafa and Abdou Allayeh

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6240 | Submission Open

Keywords: enteric viruses; respiratory viruses; human influenza viruses; COVID-19; avian influenza viruses; surveillance; virus epidemiology; viral diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Influenza Viruses in Wildlife 2026

edited by

Rebecca Poulson

and Wendy Blay Puryear

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5860 | Submission Open

Keywords: avian influenza; wild birds; wildlife; influenza epidemiology; surveillance; HPAI

(This special issue belongs to the Section Animal Viruses)

Early Diagnosis and Surveillance of Transboundary and Emerging Viral Diseases of Animals, 2nd Edition

edited by

Aruna Ambagala

and

Kalhari Goonewardene

submission deadline 30 Jun 2026 | 4 articles | Viewed by 5312 | Submission Open

Keywords: diagnostics; surveillance; transboundary; emerging; animal diseases; virus; detection; validation; novel; sample types; alternative

(This special issue belongs to the Section Animal Viruses)

HIV and Drugs of Abuse, 4th Edition

edited by

Maria Cecilia Garibaldi Marcondes

and

Marcus Kaul

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5219 | Submission Open

Keywords: substance use disorders; HIV; HAND; methamphetamine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Research of Anelloviruses, Second Edition

edited by

Fabrizio Maggi

and

Pietro Giorgio Spezia

submission deadline 30 Jun 2026 | 2 articles | Viewed by 3650 | Submission Open

Keywords: TTV; TTMV; TTMDV; virome; viral species; immune system; orphan virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

RNA Viruses Replication and Innate Immunity

edited by

Griffith Parks

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1881 | Submission Open

Keywords: RNA virus replication and transcription; pathogen-associated molecular patterns; interferons; cytokines; signaling pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Infection and Platelets’ Disorders

edited by

Pierpaolo Di Micco

Alessandro Perrella

and

Giuseppe Camporese

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1707 | Submission Open

Keywords: viral infections; thrombosis; thrombotic microangiopathies; disseminated intravascular coagulation; low molecular weight heparin; bleedings; acute infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in Honey Bee Viruses Research

edited by

Benjamin J. Lamp

and Kerstin Seitz

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1699 | Submission Open

Keywords: honey bee viruses; deformed wing virus; DWV; sacbrood virus; SBV; chronic bee paralysis virus; CBPV; acute bee paralysis virus; ABPV; Israel acute bee paralysis virus; IAPV; Iflavirus; Dicistrovirus; rhabdovirus; ARV

(This special issue belongs to the Section Invertebrate Viruses)

Advances in Parapoxvirus Research: From Veterinary Infections to Public Health Implications

edited by

Yoon-Seok Chung

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1492 | Submission Open

Keywords: parapoxviruses; zoonotic implications; diagnostic innovation; veterinary infections; molecular epidemiology; genomic surveillance

(This special issue belongs to the Section Animal Viruses)

Avian Reovirus 2026

edited by

Sunil Mor

and

Krisztián Bányai

submission deadline 30 Jun 2026 | Viewed by 898 | Submission Open

Keywords: avian reoviruses (ARVs); pathogenesis; genotyping; vaccines; poultry

(This special issue belongs to the Section Animal Viruses)

Host-Targeting Antivirals: From Mechanism to Intervention

edited by

Stephan Pleschka

submission deadline 30 Jun 2026 | Viewed by 425 | Submission Open

Keywords: host-targeting antivirals; host receptors; signaling pathways; metabolic networks; transcription factors; treatment; clinical intervention practice; preclinical data; intervention strategy design; mechanism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Porcine Virus–Host Interactions: Entry, Tropism, Immune Evasion and Control

edited by

Levon Abrahamyan

submission deadline 30 Jun 2026 | Viewed by 396 | Submission Open

Keywords: porcine viruses; virus– host interactions; viral entry; tropism; immune evasion; viral escape; antivirals; single-cell/spatial omics; cell imaging; virus trafficking

(This special issue belongs to the Section Animal Viruses)

HIV Infection, Latency, Pathogenesis and Associated Comorbidities, Including Cancer and Inflammation in the Context of Drugs of Abuse and ART

edited by

Mudit Tyagi

submission deadline 30 Jun 2026 | Viewed by 263 | Submission Open

Keywords: HIV infection; HIV transcription and latency; HIV; ART and drugs of abuse associated comorbidities in people living with HIV (PLWH); HIV; ART and drugs of abuse associated cancer; HIV; ART and drugs of abuse associated inflammation and aging

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in Viral Integration: Mechanisms, Targeting, Reservoirs and Therapeutics

edited by

Stephen Barr

submission deadline 30 Jun 2026 | Viewed by 258 | Submission Open

Keywords: viral integration; integration site selection; chromatin topology; anatomical reservoir; latent provirus; clonal expansion; insertional mutagenesis; gene therapy vector; integrase/co-factor; emerging virus integration

(This special issue belongs to the Section General Virology)

Viral Neuropathogenesis: Mechanisms, Models, and Therapeutic Strategies

edited by

Mukesh Kumar

submission deadline 30 Jun 2026 | Viewed by 251 | Submission Open

Keywords: neurotropic viruses; neuroinflammation; blood– brain barrier; CNS viral infection models; host– pathogen interactions; antiviral immunity; neurological complications; neurodegeneration; viral encephalitis

HIV and Aging

edited by Eugenia Negredo

submission deadline 1 Jul 2026 | 3 articles | Viewed by 3880 | Submission Open

Keywords: HIV and aging; accelerated and accentuated aging; immune senescence; inflammation; comorbidities; geriatric syndromes; neurocognitive function; functional status; antiretroviral therapy

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus Infection Fate Regulation

edited by Andreas Meyerhans and

Gennady Bocharov

submission deadline 1 Jul 2026 | Viewed by 800 | Submission Open

Keywords: virus infection fate; dynamics; immune response; cellular response; regulation

(This special issue belongs to the Section General Virology)

Controlling Zoonotic Viral Diseases from One Health Perspective 2026

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 15 Jul 2026 | 7 articles | Viewed by 31050 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

High Consequence Viral Transmission

edited by

Olivier Escaffre

submission deadline 17 Jul 2026 | 2 articles | Viewed by 1303 | Submission Open

Keywords: high-consequence viruses; zoonotic viruses; spillover events; natural reservoirs; wildlife vectors; pandemic; outbreaks; airborne transmission; droplet transmission; sexual transmission; high fatality rates; Filoviridae; Orthoebolavirus; Orthomarbugvirus; Paramyxoviridae; Orthoparamyxovirinae; Arenaviridae; Mammarenavirus; Peribunyaviridae; Orthobunyavirus; Nairoviridae; Orthonairovirus; Hantaviridae; Orthohantavirus; Coronaviridae; Betacoronavirus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Hepatitis Elimination: HBV, HDV, and HCV

edited by

Federico García

submission deadline 31 Jul 2026 | 13 articles | Viewed by 20081 | Submission Open

Keywords: hepatitis elimination; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Rodent-Borne Viruses 2026

edited by

Renata Carvalho De Oliveira

and

Jorlan Fernandes

submission deadline 31 Jul 2026 | 4 articles | Viewed by 14443 | Submission Open

Keywords: rodent-borne viruses; hantaviridae; arenaviridae; poxviridae; zoonosis; virus ecology and evolution; virus– host interaction; virus discovery; animal model; rodents

(This special issue belongs to the Section Animal Viruses)

Molecular Epidemiology of SARS-CoV-2, 4th Edition

edited by

Marta Giovanetti

submission deadline 31 Jul 2026 | 10 articles | Viewed by 13176 | Submission Open

Keywords: SARS-CoV-2; genomic monitoring; phylodynamic; molecular epidemiology

(This special issue belongs to the Section Coronaviruses)

Coronavirus Pathogenesis and Virus-Host Interaction

edited by

Hin Chu

submission deadline 31 Jul 2026 | 4 articles | Viewed by 6910 | Submission Open

Keywords: COVID-19; SARS-CoV-2; SARS-CoV-1; MERS-CoV; pathogenesis; virus– host interaction; virus entry; host factors; animal models; SARS-CoV-2 variants

(This special issue belongs to the Section General Virology)

HIV in the Context of Chronic Disorders and Aging

edited by

Maria Mazzitelli

Andrea De Vito

and Mattia Trunfio

submission deadline 31 Jul 2026 | 5 articles | Viewed by 6367 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

Translational Research in Virology

edited by

Kenneth Lundstrom

and

Alaa A. A. Aljabali

submission deadline 31 Jul 2026 | 2 articles | Viewed by 5943 | Submission Open

Keywords: vaccines; antiviral drugs; monoclonal antibodies; viral vectors; self-amplifying RNA; clinical trials; translational medicine; proteomic analysis; antiviral resistance; bioinformatics; structural virology; immune escape mechanisms; viral evolution; diagnostic virology; high-throughput screening; nanotechnology in virology; viral assembly and disassembly; host-pathogen interactions; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infection in Airway Epithelial Cells

edited by Camille Ehré and Raymond J. Pickles

submission deadline 31 Jul 2026 | 2 articles | Viewed by 5397 | Submission Open

Keywords: respiratory viral infections; airway epithelial cells; virus– host interactions; viral pathogenesis; immune responses; Influenza viruses; respiratory syncytial virus (rsv); coronaviruses; SARS-CoV-2; respiratory tract

(This special issue belongs to the Section Animal Viruses)

RSV Epidemiological Surveillance: 3rd Edition

edited by Emanuele Castagno and Irene Raffaldi

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4945 | Submission Open

Keywords: respiratory syncytial virus (RSV); epidemiological surveillance; bronchiolitis; children; newborns; infants

(This special issue belongs to the Section Human Virology and Viral Diseases)

Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals

edited by

Jing Zhang

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4830 | Submission Open

Keywords: vaccines; antiviral drugs; domestic animals; virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus-Host Interactions: From Mechanisms to Therapeutics

edited by

Leike Zhang

and

Ke Xu

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4760 | Submission Open

Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral– host interplay

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Nuclear Architecture in Viral Infection

edited by Veronica Sanchez and Elizabeth White

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4065 | Submission Open

Keywords: nuclear architecture; viral transcription; viral replication; viral assembly

(This special issue belongs to the Section General Virology)

Zika Virus and Congenital Zika Syndrome, 2nd Edition

edited by Marcos Vinicius da Silva Pone and Sheila Moura Pone

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3558 | Submission Open

Keywords: viral infections; Zika virus; congenital Zika syndrome

(This special issue belongs to the Section Human Virology and Viral Diseases)

Foot-and-Mouth Disease Virus

edited by

Satya Parida

Zhidong Zhang

and

Madhanmohan Muthukrishnan

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3525 | Submission Open

Keywords: foot-and-mouth disease; foot-and-mouth disease virus; hoof-and-mouth disease; FMD; FMD virus; foot-and-mouth disease vaccines

(This special issue belongs to the Section Animal Viruses)

Dual Nature of Bacteriophages: Friends or Enemies in the Food Industry?—2nd Edition

edited by

Michał Wójcicki

Barbara Sokolowska

and

Ewa Jończyk-Matysiak

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3505 | Submission Open

Keywords: bacteriophages; biocontrol; biosensors; food safety; foodborne bacterial pathogens; food quality; foodborne saprophytic bacteria

(This special issue belongs to the Section Bacterial Viruses)

Congenital Cytomegalovirus Infection, 3rd Edition

edited by

Giovanni Nigro

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2967 | Submission Open

Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virology and Immunology of Gene Therapy 2026

edited by Weidong Xiao and

Jianming Qiu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2819 | Submission Open

Keywords: gene therapy; viral vector; vaccine; immune responses; viruses; AAV; lentiviral vectors; neutralizing antibody

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viroinformatics and Viral Diseases

edited by

Hernan Garcia-Ruiz

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2435 | Submission Open

Keywords: viral genomics; virus variation; genome-wide variation; gene silencing; antiviral defense; virus replication; host factors; high-throughput sequencing; small RNA sequencing

(This special issue belongs to the Section General Virology)

Structural and Mechanistic Advances in Retroviral Biology

edited by Yong Xiong,

Swapnil Chandrakant Devarkar

and

Luiza Mendonca

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1622 | Submission Open

Keywords: retroviruses; capsid structure and assembly; host-viral interactions; in situ cryo EM; reverse transcription; integration; genome packaging

(This special issue belongs to the Section Human Virology and Viral Diseases)

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