Synthesis of 2- and 7- Substituted C19 Steroids Having a 1,4,6-Triene or 1,4-Diene Structure and Their Cytotoxic Effects on T47D and MDA-MB231 Breast Cancer Cells
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Cytotoxic effects
Compound No. | T47D cells | MDA-MB231 cells |
---|---|---|
IC50 (μM) | IC50 (μM) | |
Formestane | 96.5 | >100 |
Tamoxifen | 13.0 | 11.4 |
2 | 7.1 | >100 |
3 | >100 | >100 |
4 | >100 | >100 |
5 | >100 | 18.7 |
7 | >100 | >100 |
8 | 17.3 | 26.9 |
9 | 36.4 | 53.5 |
10 | 44.2 | 33.1 |
11 | 95.6 | >100 |
12 | 54.3 | 43.8 |
13 | >100 | >100 |
14 | 97.1 | >100 |
3. Conclusions
4. Experimental
4.1. General
4.2. Synthesis of 2-substituted-1,4,6-androstatriene-3,17-dione derivatives
4.3. Synthesis of 7-substituted-1,4-androstadiene-3,17-dione derivatives
4.4. Biology
MTT assay on T47D and MDA-MB231 cells
Acknowledgements
References
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Kim, M.; Ma, E. Synthesis of 2- and 7- Substituted C19 Steroids Having a 1,4,6-Triene or 1,4-Diene Structure and Their Cytotoxic Effects on T47D and MDA-MB231 Breast Cancer Cells. Molecules 2010, 15, 4408-4422. https://doi.org/10.3390/molecules15064408
Kim M, Ma E. Synthesis of 2- and 7- Substituted C19 Steroids Having a 1,4,6-Triene or 1,4-Diene Structure and Their Cytotoxic Effects on T47D and MDA-MB231 Breast Cancer Cells. Molecules. 2010; 15(6):4408-4422. https://doi.org/10.3390/molecules15064408
Chicago/Turabian StyleKim, Minwoo, and Eunsook Ma. 2010. "Synthesis of 2- and 7- Substituted C19 Steroids Having a 1,4,6-Triene or 1,4-Diene Structure and Their Cytotoxic Effects on T47D and MDA-MB231 Breast Cancer Cells" Molecules 15, no. 6: 4408-4422. https://doi.org/10.3390/molecules15064408