Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide–Protein Interactions
Abstract
:1. Introduction
2. Oxime Ligation: General Protocol
3. Application to Tsg101-Binding Peptides
4. Application to Peptide–Protein Interactions of Protein Tyrosine Phosphatases
5. Application to Plk1 PBD-Binding Peptides
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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No. | R | IC50(nM) a | ||
---|---|---|---|---|
Plk1 | Plk2 | Plk3 | ||
12 | n/a | 5 | 130 (26×) b | 280 (56×) |
17 | | 7 | 290 (44×) | 1500 (220×) |
18 | | 6 | 3400 (620×) | 1900 (345×) |
19 | | 11 | 3500 (312×) | 29,500 (2600×) |
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Zhao, X.Z.; Liu, F.; Burke, T.R., Jr. Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide–Protein Interactions. Molecules 2020, 25, 2807. https://doi.org/10.3390/molecules25122807
Zhao XZ, Liu F, Burke TR Jr. Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide–Protein Interactions. Molecules. 2020; 25(12):2807. https://doi.org/10.3390/molecules25122807
Chicago/Turabian StyleZhao, Xue Zhi, Fa Liu, and Terrence R. Burke, Jr. 2020. "Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide–Protein Interactions" Molecules 25, no. 12: 2807. https://doi.org/10.3390/molecules25122807