The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril® 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. Materials
3.2. Gel Preparation
3.3. Methods
3.3.1. Rheological Studies
3.3.2. Textural Analysis
Back Extrusion Test
Spreadability Test
3.3.3. Release Test in Vitro
HPLC Analysis
3.3.4. Statistical Analysis
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Gel Sample | Consistency Index (K) | Flow Behavior Index (n) | ||
---|---|---|---|---|
25 °C | 37 °C | 25 °C | 37 °C | |
pH 5.5 | 65.31 ± 2.36 | 58.26 ± 2.01 | 0.134 ± 0.005 | 0.132 ± 0.005 |
pH 6.0 | 80.83 ± 1.58 | 78.83 ± 1.05 | 0.127 ± 0.002 | 0.124 ± 0.002 |
pH 6.6 | 97.57 ± 2.04 | 95.27 ± 1.74 | 0.126 ± 0.004 | 0.123 ± 0.002 |
Dentinox-N | 74.04 ± 1.75 | 70.04 ± 1.75 | 0.129 ± 0.004 | 0.125 ± 0.003 |
Gel Sample | API | Released amount of APIs, mg/cm3 | |||||
---|---|---|---|---|---|---|---|
Samples Selection Time, h | |||||||
0.5 | 1 | 2 | 3 | 4 | 6 | ||
pH 5.5 | ChSal | 1.350 ± 0.165 | 2.680 ± 0.730 | 7.491 ± 1.762 | 12.637 ± 2.025 | 17.350 ± 2.581 | 25.201 ± 2.780 |
LidHyd | 0.233 ± 0.011 | 0.587 ± 0.027 | 0.793 ± 0.038 | 1.058 ± 0.047 | 1.212 ± 0.056 | 1.317 ± 0.061 | |
pH 6.0 | ChSal | 1.055 ± 0.172 | 2.680 ± 0.331 | 7.215 ± 0.398 | 12.338 ± 0.606 | 16.884 ± 0.263 | 24.440 ± 0.360 |
LidHyd | 0.203 ± 0.009 | 0.517 ± 0.025 | 0.748 ± 0.033 | 0.956 ± 0.041 | 1.145 ± 0.054 | 1.251 ± 0.059 | |
pH 6.6 | ChSal | 1.105 ± 0.035 | 2.822 ± 0.429 | 7.194 ± 0.972 | 12.261 ± 1.019 | 16.663 ± 1.915 | 24.015 ± 2.744 |
LidHyd | 0.215 ± 0.010 | 0.533 ± 0.026 | 0.764 ± 0.035 | 0.998 ± 0.044 | 1.154 ± 0.056 | 1.267 ± 0.060 | |
Control | ChSal | 17.262 ± 0.141 | 31.630 ± 0.510 | 47.076 ± 1.044 | 50.545 ± 1.123 | 51.342 ± 1.811 | 51.671 ± 2.012 |
LidHyd | 0.668 ± 0.029 | 1.191 ± 0.057 | 1.388 ± 0.066 | 1.437 ± 0.070 | 1.459 ± 0.071 | 1.481 ± 0.071 |
Ingredients | Amount, % |
---|---|
Tincture “Phytodent” | 15.0 |
Choline salicylate 80% | 8.0 |
Lidocaine hydrochloride | 1.5 |
Carbomer homopolymer (Polacril® 40P) | 1.5 |
Sodium hydroxide (10% solution) | to the required pH |
Vinyl methyl ether and maleic anhydride copolymer | |
(OraRez® W-100L16) | 1.5 |
Methyl parahydroxybenzoate | 0.15 |
Propyl parahydroxybenzoate | 0.05 |
Purified water | Up to 100.0 |
Sample Availability: Samples of the developed gel are available from the authors. |
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Maslii, Y.; Ruban, O.; Kasparaviciene, G.; Kalveniene, Z.; Materiienko, A.; Ivanauskas, L.; Mazurkeviciute, A.; Kopustinskiene, D.M.; Bernatoniene, J. The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril® 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components. Molecules 2020, 25, 5018. https://doi.org/10.3390/molecules25215018
Maslii Y, Ruban O, Kasparaviciene G, Kalveniene Z, Materiienko A, Ivanauskas L, Mazurkeviciute A, Kopustinskiene DM, Bernatoniene J. The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril® 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components. Molecules. 2020; 25(21):5018. https://doi.org/10.3390/molecules25215018
Chicago/Turabian StyleMaslii, Yuliia, Olena Ruban, Giedre Kasparaviciene, Zenona Kalveniene, Anna Materiienko, Liudas Ivanauskas, Agne Mazurkeviciute, Dalia M. Kopustinskiene, and Jurga Bernatoniene. 2020. "The Influence of pH Values on the Rheological, Textural and Release Properties of Carbomer Polacril® 40P-Based Dental Gel Formulation with Plant-Derived and Synthetic Active Components" Molecules 25, no. 21: 5018. https://doi.org/10.3390/molecules25215018