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Article

Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity

by
Roxana Racoviceanu
1,†,
Cristina Trandafirescu
1,†,
Mirela Voicu
2,*,
Roxana Ghiulai
1,*,
Florin Borcan
3,
Cristina Dehelean
4,
Claudia Watz
5,
Zoltán Aigner
6,
Rita Ambrus
6,
Dorina Elena Coricovac
4,
Denisa Cîrcioban
3,
Alexandra Mioc
7,
Camelia Alexandrina Szuhanek
8 and
Codruţa Şoica
1
1
Department of Pharmaceutical Chemistry, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
2
Department of Pharmacology and Clinical Pharmacy, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
3
Department of Analytical Chemistry, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
4
Department of Toxicology, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
5
Department of Pharmaceutical Physics, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
6
Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, 6th Eotvos Str., 6720 Szeged, Hungary
7
Department of Anatomy, Physiology and Physiopathology, Victor Babeș University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timisoara, Romania
8
Department of Orthodontics, Victor Babeș University of Medicine and Pharmacy, 9th Revolutiei din 1989 Bvd, 300041 Timisoara, Romania
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2020, 25(21), 5130; https://doi.org/10.3390/molecules25215130
Submission received: 1 October 2020 / Revised: 29 October 2020 / Accepted: 2 November 2020 / Published: 4 November 2020
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Abstract

Albendazole is a benzimidazole derivative with documented antitumor activity and low toxicity to healthy cells. The major disadvantage in terms of clinical use is its low aqueous solubility which limits its bioavailability. Albendazole was incorporated into stable and homogeneous polyurethane structures with the aim of obtaining an improved drug delivery system model. Spectral and thermal analysis was used to investigate the encapsulation process and confirmed the presence of albendazole inside the nanoparticles. The in vitro anticancer properties of albendazole encapsulated in polyurethane structures versus the un-encapsulated compound were tested on two breast cancer cell lines, MCF-7 and MDA-MB-231, in terms of cellular viability and apoptosis induction. The study showed that the encapsulation process enhanced the antitumor activity of albendazole on the MCF-7 and MDA-MB-23 breast cancer lines. The cytotoxic activity manifested in a concentration-dependent manner and was accompanied by changes in cell morphology and nuclear fragmentation.
Keywords: albendazole; polyurethane; nanoparticles; cell viability albendazole; polyurethane; nanoparticles; cell viability

Share and Cite

MDPI and ACS Style

Racoviceanu, R.; Trandafirescu, C.; Voicu, M.; Ghiulai, R.; Borcan, F.; Dehelean, C.; Watz, C.; Aigner, Z.; Ambrus, R.; Coricovac, D.E.; et al. Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity. Molecules 2020, 25, 5130. https://doi.org/10.3390/molecules25215130

AMA Style

Racoviceanu R, Trandafirescu C, Voicu M, Ghiulai R, Borcan F, Dehelean C, Watz C, Aigner Z, Ambrus R, Coricovac DE, et al. Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity. Molecules. 2020; 25(21):5130. https://doi.org/10.3390/molecules25215130

Chicago/Turabian Style

Racoviceanu, Roxana, Cristina Trandafirescu, Mirela Voicu, Roxana Ghiulai, Florin Borcan, Cristina Dehelean, Claudia Watz, Zoltán Aigner, Rita Ambrus, Dorina Elena Coricovac, and et al. 2020. "Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity" Molecules 25, no. 21: 5130. https://doi.org/10.3390/molecules25215130

APA Style

Racoviceanu, R., Trandafirescu, C., Voicu, M., Ghiulai, R., Borcan, F., Dehelean, C., Watz, C., Aigner, Z., Ambrus, R., Coricovac, D. E., Cîrcioban, D., Mioc, A., Szuhanek, C. A., & Şoica, C. (2020). Solid Polymeric Nanoparticles of Albendazole: Synthesis, Physico-Chemical Characterization and Biological Activity. Molecules, 25(21), 5130. https://doi.org/10.3390/molecules25215130

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