Functionalization of Polyethyleneimine with Hollow Cyclotriveratrylene and Its Subsequent Supramolecular Interaction with Doxorubicin
Abstract
:1. Introduction
2. Methods and Results
2.1. Synthesis of the Cross-Linker
2.2. Preparation of the Cross-Linked Polymer
2.3. Coordination of Doxorubicin
2.4. Computational Analysis of Supramolecular Assembly
3. Materials and Methods
3.1. Materials
3.2. Synthetic Procedures
3.3. Computational Analysis
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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mg of Titrant 1 (Solvent) | λ1, λ2 (nm) | ε1, ε2, (M−1 cm−1) |
---|---|---|
0 mg (MeOH) | 475, 495 | 18,560, 17,460 |
5 mg 2 of 3a (MeOH) | 475, 495 | 10,860, 10,840 |
3 mg 3 (of 3a (MeOH aged 20 days) | 500, 535 | 13,060, 13,330 |
3 mg 3 of PEI (MeOH) | 480, 495 | 17,400, 17,460 |
0 mg (DMSO) | 480 | 9260 |
3 mg 3 of 3a (DMSO) | 485 | 10,200 |
3 mg 3 of 3a (DMSO aged 20 days) | 485 | 10,200 |
3 mg 4 of PEI (DMSO) | 500, 595 | 7330, 3420 |
0 mg of (H2O) | 480 | 13,200 |
3 mg 3 of 3a (H2O) | 485, 495 | 10,860, 10,850 |
3 mg 3 of 3a (H2O aged 20 days) | 510 | 7010 |
3 mg 4 of PEI (H2O) | 550, 590 | 10,300, 9100 |
Protons 2 | (MeOD) | +3a (MeOD) | +PEI (MeOD) | (DMSO) | +3a (DMSO) | (D2O) | +3a (D2O) | +3a aged (D2O) |
---|---|---|---|---|---|---|---|---|
-H1 | 7.99 | 7.97 | 7.73 | 7.85 | 7.89 | 7.22 | 7.20 | 7.26 |
-H2 | 7.86 | 7.83 | 7.46 | 7.85 | 7.89 | 7.50 | 7.48 | 7.53 |
-H3 | 7.60 | 7.57 | 7.46 | 7.61 | 7.65 | 7.22 | 7.20 | 7.26 |
-OH 9,4 | 5.46 | 5.43 | 5.35 | 5.46 | 5.43 | - | - | - |
-H1′ | 5.12 | 5.12 | 4.98 | 5.27 | 5.27 | 5.39 | 5.37 | 5.41 |
-H5′ | 4.29 | 4.25 | 4.18 | 4.19 | 4.16 | 4.18 | 4.18 | 4.20 |
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Coluccini, C.; Ng, Y.M.; Reyes, Y.I.A.; Chen, H.-Y.T.; Khung, Y.L. Functionalization of Polyethyleneimine with Hollow Cyclotriveratrylene and Its Subsequent Supramolecular Interaction with Doxorubicin. Molecules 2020, 25, 5455. https://doi.org/10.3390/molecules25225455
Coluccini C, Ng YM, Reyes YIA, Chen H-YT, Khung YL. Functionalization of Polyethyleneimine with Hollow Cyclotriveratrylene and Its Subsequent Supramolecular Interaction with Doxorubicin. Molecules. 2020; 25(22):5455. https://doi.org/10.3390/molecules25225455
Chicago/Turabian StyleColuccini, Carmine, Yoke Mooi Ng, Yves Ira A. Reyes, Hsin-Yi Tiffany Chen, and Yit Lung Khung. 2020. "Functionalization of Polyethyleneimine with Hollow Cyclotriveratrylene and Its Subsequent Supramolecular Interaction with Doxorubicin" Molecules 25, no. 22: 5455. https://doi.org/10.3390/molecules25225455