Next Article in Journal
The Effects of Selenium on Bone Health: From Element to Therapeutics
Previous Article in Journal
Studies on the Formation of Catalytically Active PGM Nanoparticles from Model Solutions as a Basis for the Recycling of Spent Catalysts
Previous Article in Special Issue
Nanoformulation Development to Improve the Biopharmaceutical Properties of Fisetin Using Design of Experiment Approach
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 27
Issue 2
10.3390/molecules27020391
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture

by
Jesús Alfredo Araujo-León
1,
Rolffy Ortiz-Andrade
2,*,
Efrén Hernández-Baltazar
3,
Emanuel Hernández-Núñez
4,
Julio César Rivera-Leyva
5,
Víctor Yáñez-Pérez
6,
Priscila Vazquez-Garcia
1,2,
Carla Georgina Cicero-Sarmiento
2,7,
Juan Carlos Sánchez-Salgado
8 and
Maira Rubí Segura-Campos
9
1
Laboratorio de Cromatografía, Facultad de Química, Universidad Autónoma de Yucatán, Merida 97069, Mexico
2
Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Merida 97069, Mexico
3
Laboratorio de Tecnología Farmacéutica, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Mexico
4
Departamento de Recursos del Mar, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional-Unidad Mérida, Merida 97205, Mexico
5
Laboratorio 4, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62209, Mexico
6
Bioterio de la Escuela de Medicina, Universidad Anáhuac-Mayab, Merida 97302, Mexico
7
Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico
8
Hypermedic MX, Ciudad de Mexico 04930, Mexico
9
Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Merida 97203, Mexico
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(2), 391; https://doi.org/10.3390/molecules27020391
Submission received: 2 December 2021 / Revised: 24 December 2021 / Accepted: 6 January 2022 / Published: 8 January 2022
(This article belongs to the Special Issue Natural Products: Pharmacokinetics, Pharmacodynamics, and Drug Interaction Potential)
Browse Figures
Review Reports Versions Notes

Abstract

This study was performed to evaluate and compare the pharmacokinetic parameters between two dosage formulations of hesperidin and naringenin: mixture and tablet. Our objective was to determine that the flavonoid tablet does not significantly modify the pharmacokinetic parameters compared with the mixture. For this study, we administered 161 mg/kg of either mixture (Mix-160) or tablet composed of hesperidin and by intragastric administration. Blood microsamples were collected from tail vein up to 24 h. Serum flavonoid extraction was performed by solid phase extraction and analyzed by LC-MS/MS of triple quadrupole (QqQ). Serum concentration vs. time plot showed that data fitted for a first-order model. The pharmacokinetic parameters were calculated by a noncompartmental model. The results showed that the absorption constant is higher than the elimination constant. The first concentration was found at five minutes, and minimal concentration at 24 h after administration, suggesting a enterohepatic recirculation phenomena and regulation of liver cytochromes’ activity. We did not find meaningful differences between the pharmacokinetic parameters of both samples. We concluded that tablet form did not interfere with the bioavailability of hesperidin and naringenin, and it could be a suitable candidate for developing a drug product.
Keywords: LC-MS/MS; flavonoids; hesperidin; naringenin; pharmacokinetics LC-MS/MS; flavonoids; hesperidin; naringenin; pharmacokinetics
Graphical Abstract

Share and Cite

MDPI and ACS Style

Araujo-León, J.A.; Ortiz-Andrade, R.; Hernández-Baltazar, E.; Hernández-Núñez, E.; Rivera-Leyva, J.C.; Yáñez-Pérez, V.; Vazquez-Garcia, P.; Cicero-Sarmiento, C.G.; Sánchez-Salgado, J.C.; Segura-Campos, M.R. A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture. Molecules 2022, 27, 391. https://doi.org/10.3390/molecules27020391

AMA Style

Araujo-León JA, Ortiz-Andrade R, Hernández-Baltazar E, Hernández-Núñez E, Rivera-Leyva JC, Yáñez-Pérez V, Vazquez-Garcia P, Cicero-Sarmiento CG, Sánchez-Salgado JC, Segura-Campos MR. A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture. Molecules. 2022; 27(2):391. https://doi.org/10.3390/molecules27020391

Chicago/Turabian Style

Araujo-León, Jesús Alfredo, Rolffy Ortiz-Andrade, Efrén Hernández-Baltazar, Emanuel Hernández-Núñez, Julio César Rivera-Leyva, Víctor Yáñez-Pérez, Priscila Vazquez-Garcia, Carla Georgina Cicero-Sarmiento, Juan Carlos Sánchez-Salgado, and Maira Rubí Segura-Campos. 2022. "A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture" Molecules 27, no. 2: 391. https://doi.org/10.3390/molecules27020391

APA Style

Araujo-León, J. A., Ortiz-Andrade, R., Hernández-Baltazar, E., Hernández-Núñez, E., Rivera-Leyva, J. C., Yáñez-Pérez, V., Vazquez-Garcia, P., Cicero-Sarmiento, C. G., Sánchez-Salgado, J. C., & Segura-Campos, M. R. (2022). A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture. Molecules, 27(2), 391. https://doi.org/10.3390/molecules27020391

Article Metrics

Back to TopTop