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Molecules
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Natural Products: Pharmacokinetics, Pharmacodynamics, and Drug Interaction Potential
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Natural Products: Pharmacokinetics, Pharmacodynamics, and Drug Interaction Potential

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 6300

Special Issue Editor

Prof. Dr. Tung-Hu Tsai

E-Mail Website
Guest Editor
Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan
Interests: animal experiment; blood–brain barrier; blood–placental barrier; drug–drug interactions; enterohepatic circulation; food chemistry; herbal medicine; liquid chromatography; LC-MS/MS; microdialysis; natural products; neurochemistry; pharmaceutical analysis; pharmacodynamics; pharmacokinetics; traditional Chinese medicine; transporter mechanism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmacokinetics is the subject of investigating the process of drug absorption, distribution, metabolisms, and excretion, while pharmacodynamics explores the pharmacological effect of drugs and their action mechanisms within the biological system, both in vitro and in vivo. Natural products—naturally occurring chemical compounds produced by living organisms—are ever-popular research subjects, providing inspiration for new candidate drugs. Studies typically focus on phytochemical substances, such as phenols, polyphenols, tannins, terpenes, and alkaloids. This Special Issue of Molecules aims to provide a scientific forum to discuss pharmacokinetics, pharmacodynamics, and potential herbal drug interactions of natural products. Manuscripts submitted to this Special Issue should contain a characterization of chemical constituents.

Prof. Dr. Tung-Hu Tsai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemical analysis
  • drug delivery
  • drug-drug interactions
  • herbal drug interactions
  • metabolism
  • natural products
  • pharmacodynamics
  • pharmacokinetics
  • phytomedicine

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Published Papers (2 papers)

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8 pages, 1116 KiB  
Article
A Pharmacokinetic Study of Mix-160 by LC-MS/MS: Oral Bioavailability of a Dosage Form of Citroflavonoids Mixture
by Jesús Alfredo Araujo-León, Rolffy Ortiz-Andrade, Efrén Hernández-Baltazar, Emanuel Hernández-Núñez, Julio César Rivera-Leyva, Víctor Yáñez-Pérez, Priscila Vazquez-Garcia, Carla Georgina Cicero-Sarmiento, Juan Carlos Sánchez-Salgado and Maira Rubí Segura-Campos
Molecules 2022, 27(2), 391; https://doi.org/10.3390/molecules27020391 - 8 Jan 2022
Cited by 2 | Viewed by 2231
Abstract
This study was performed to evaluate and compare the pharmacokinetic parameters between two dosage formulations of hesperidin and naringenin: mixture and tablet. Our objective was to determine that the flavonoid tablet does not significantly modify the pharmacokinetic parameters compared with the mixture. For [...] Read more.
This study was performed to evaluate and compare the pharmacokinetic parameters between two dosage formulations of hesperidin and naringenin: mixture and tablet. Our objective was to determine that the flavonoid tablet does not significantly modify the pharmacokinetic parameters compared with the mixture. For this study, we administered 161 mg/kg of either mixture (Mix-160) or tablet composed of hesperidin and by intragastric administration. Blood microsamples were collected from tail vein up to 24 h. Serum flavonoid extraction was performed by solid phase extraction and analyzed by LC-MS/MS of triple quadrupole (QqQ). Serum concentration vs. time plot showed that data fitted for a first-order model. The pharmacokinetic parameters were calculated by a noncompartmental model. The results showed that the absorption constant is higher than the elimination constant. The first concentration was found at five minutes, and minimal concentration at 24 h after administration, suggesting a enterohepatic recirculation phenomena and regulation of liver cytochromes’ activity. We did not find meaningful differences between the pharmacokinetic parameters of both samples. We concluded that tablet form did not interfere with the bioavailability of hesperidin and naringenin, and it could be a suitable candidate for developing a drug product. Full article
(This article belongs to the Special Issue Natural Products: Pharmacokinetics, Pharmacodynamics, and Drug Interaction Potential)
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18 pages, 3166 KiB  
Article
Nanoformulation Development to Improve the Biopharmaceutical Properties of Fisetin Using Design of Experiment Approach
by Wan-Yi Liu, Chia-Chen Lin, Yun-Shan Hsieh and Yu-Tse Wu
Molecules 2021, 26(10), 3031; https://doi.org/10.3390/molecules26103031 - 19 May 2021
Cited by 30 | Viewed by 3273
Abstract
This study aimed to design an effective nanoparticle-based carrier for the oral delivery of fisetin (FST) with improved biopharmaceutical properties. FST-loaded nanoparticles were prepared with polyvinyl alcohol (PVA) and poly(lactic-co-glycolic acid) (PLGA) by the interfacial deposition method. A central composite design of two [...] Read more.
This study aimed to design an effective nanoparticle-based carrier for the oral delivery of fisetin (FST) with improved biopharmaceutical properties. FST-loaded nanoparticles were prepared with polyvinyl alcohol (PVA) and poly(lactic-co-glycolic acid) (PLGA) by the interfacial deposition method. A central composite design of two independent variables, the concentration of PVA and the amount of PLGA, was applied for the optimization of the preparative parameter. The responses, including average particle size, polydispersity index, encapsulation efficiency, and zeta potential, were assessed. The optimized formulation possessed a mean particle size of 187.9 nm, the polydispersity index of 0.121, encapsulation efficiency of 79.3%, and zeta potential of −29.2 mV. The morphological observation demonstrated a globular shape for particles. Differential scanning calorimetry and powder X-ray diffraction studies confirmed that the encapsulated FST was presented as the amorphous state. The dissolution test indicated a 3.06-fold increase for the accumulating concentrations, and the everted gut sac test showed a 4.9-fold gain for permeability at the duodenum region. In conclusion, the optimized FST-loaded nanoparticle formulation in this work can be developed as an efficient oral delivery system of FST to improve its biopharmaceutic properties. Full article
(This article belongs to the Special Issue Natural Products: Pharmacokinetics, Pharmacodynamics, and Drug Interaction Potential)
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