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Article

Comprehensive Assessment of Collagen/Sodium Alginate-Based Sponges as Hemostatic Dressings

by
Leilei Sun
*,
Yanyan Shen
,
Mingbo Li
,
Qiuting Wang
,
Ruimin Li
and
Shunmin Gong
College of Life Science, Yantai University, Yantai 264005, China
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(13), 2999; https://doi.org/10.3390/molecules29132999
Submission received: 24 May 2024 / Revised: 17 June 2024 / Accepted: 21 June 2024 / Published: 24 June 2024
(This article belongs to the Special Issue Synthesis and Applications of Natural Polymers and Their Derivatives)

Abstract

In our search for a biocompatible composite hemostatic dressing, we focused on the design of a novel biomaterial composed of two natural biological components, collagen and sodium alginate (SA), cross-linked using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) and oxidized sodium alginate (OSA). We conducted a series of tests to evaluate the physicochemical properties, acute systemic toxicity, skin irritation, intradermal reaction, sensitization, cytotoxicity, and in vivo femoral artery hemorrhage model. The results demonstrated the excellent biocompatibility of the collagen/sodium alginate (C/SA)-based dressings before and after crosslinking. Specifically, the femoral artery hemorrhage model revealed a significantly shortened hemostasis time of 132.5 ± 12.82 s for the EDC/NHS cross-linked dressings compared to the gauze in the blank group (hemostasis time of 251.43 ± 10.69 s). These findings indicated that C/SA-based dressings exhibited both good biocompatibility and a significant hemostatic effect, making them suitable for biomedical applications.
Keywords: collagen; sodium alginate; crosslinking; biocompatibility; hemostatic dressing collagen; sodium alginate; crosslinking; biocompatibility; hemostatic dressing

Share and Cite

MDPI and ACS Style

Sun, L.; Shen, Y.; Li, M.; Wang, Q.; Li, R.; Gong, S. Comprehensive Assessment of Collagen/Sodium Alginate-Based Sponges as Hemostatic Dressings. Molecules 2024, 29, 2999. https://doi.org/10.3390/molecules29132999

AMA Style

Sun L, Shen Y, Li M, Wang Q, Li R, Gong S. Comprehensive Assessment of Collagen/Sodium Alginate-Based Sponges as Hemostatic Dressings. Molecules. 2024; 29(13):2999. https://doi.org/10.3390/molecules29132999

Chicago/Turabian Style

Sun, Leilei, Yanyan Shen, Mingbo Li, Qiuting Wang, Ruimin Li, and Shunmin Gong. 2024. "Comprehensive Assessment of Collagen/Sodium Alginate-Based Sponges as Hemostatic Dressings" Molecules 29, no. 13: 2999. https://doi.org/10.3390/molecules29132999

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