Biotransformation of Sumatriptan by Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Salmonella enterica subsp. enterica
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Biotransformation Study
4.3. High-Performance Liquid Chromatography–Photometric Diode Array (HPLC-PDA) and Liquid Chromatography–Mass Spectrometric (LC-MS) Analyses
4.4. NMR Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Organism | TIC, tr (min) | [M]+ (amu) | Fragmentation Pattern (amu) |
---|---|---|---|
B. subtilis | 1.126 | [C8H10S]+ | |
Salmonella spp. | 1.111 | ||
Salmonella spp. | 0.994 | ||
P. aeruginosa | 1.126 | ||
B. subtilis | 1.133 | ||
S. aureus | 1.214 |
Metabolite | LD50 (rat) a mg kg−1 | Pharmacological Properties b |
---|---|---|
(3-methylphenyl)methanethiol (Mw 138.23 g mol−1; CAS # 25697-56-7) | 618.96 | Gastrointestinal absorption: High BBB permeation: Yes Cytochrome P450 1A2 inhibitor: Yes—could result in increased toxicity for CYP1A2 substrates CYP2C19 inhibitor: No, CYP2C9 inhibitor: No CYP2D6 inhibitor: No, CYP3A4 inhibitor: No |
1-(4-amino-3-ethylphenyl)-N-methylmethanesulfonamide (Mw 228.31 g mol−1) | 2461.97 | Gastrointestinal absorption: High BBB permeation: No Cytochrome P450 1A2 inhibitor: No CYP2C19 inhibitor: No, CYP2C9 inhibitor: No CYP2D6 inhibitor: No, CYP3A4 inhibitor: No |
1-{4-amino-3-[(1E)-3-(dimethylamino)prop-1-en-1-yl]phenyl}methanesulfinamide (Mw 253.36 g mol−1) Sumatriptan succinate | 201 2939 | Gastrointestinal absorption: High BBB permeation: No Cytochrome P450 1A2 inhibitor: No CYP2C19 inhibitor: No, CYP2C9 inhibitor: No CYP2D6 inhibitor: No, CYP3A4 inhibitor: No |
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Jehangir, M.; Iqbal, M.S.; Aftab, U. Biotransformation of Sumatriptan by Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Salmonella enterica subsp. enterica. Molecules 2024, 29, 4226. https://doi.org/10.3390/molecules29174226
Jehangir M, Iqbal MS, Aftab U. Biotransformation of Sumatriptan by Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Salmonella enterica subsp. enterica. Molecules. 2024; 29(17):4226. https://doi.org/10.3390/molecules29174226
Chicago/Turabian StyleJehangir, Muhammad, Mohammad Saeed Iqbal, and Usman Aftab. 2024. "Biotransformation of Sumatriptan by Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Salmonella enterica subsp. enterica" Molecules 29, no. 17: 4226. https://doi.org/10.3390/molecules29174226