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Open AccessArticle
Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes
by
Shengzhou Jin
Shengzhou Jin 3,
Lanfen Wang
Lanfen Wang 1,
Yinggang Jia
Yinggang Jia 1,
Wenbo Ma
Wenbo Ma 2,* and
Dingyi Wang
Dingyi Wang 1,*
1
College of Sciences, Northeastern University, Shenyang 110004, China
2
Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics, National Base for International Science and Technology Cooperation of Chengdu University, Chengdu University, Chengdu 610106, China
3
Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, China
*
Authors to whom correspondence should be addressed.
Molecules 2024, 29(18), 4295; https://doi.org/10.3390/molecules29184295 (registering DOI)
Submission received: 13 August 2024
/
Revised: 5 September 2024
/
Accepted: 6 September 2024
/
Published: 10 September 2024
Abstract
Ketones, prevalent in many biologically significant molecules, require the development of novel methods to synthesize these structures, which is a critical endeavor in organic synthesis. Transition metal catalysis has proven to be an effective method for synthesizing ketones. However, the scope of these substrates remains relatively limited, particularly due to their incompatibility with sensitive functional groups. Herein, we report a Ni-catalyzed three-component 1,2-carboacylation of alkenes, which activates secondary/tertiary alkyl bromides. This method offers significant advantages: simplicity of operation, ready availability of substrates, and broad substrate applicability. A series of experimental studies have helped clarify the key mechanistic pathways involved in this cascade reaction.
Share and Cite
MDPI and ACS Style
Jin, S.; Wang, L.; Jia, Y.; Ma, W.; Wang, D.
Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes. Molecules 2024, 29, 4295.
https://doi.org/10.3390/molecules29184295
AMA Style
Jin S, Wang L, Jia Y, Ma W, Wang D.
Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes. Molecules. 2024; 29(18):4295.
https://doi.org/10.3390/molecules29184295
Chicago/Turabian Style
Jin, Shengzhou, Lanfen Wang, Yinggang Jia, Wenbo Ma, and Dingyi Wang.
2024. "Nickel-Catalyzed Three-Component 1,2-Carboacylation of Alkenes" Molecules 29, no. 18: 4295.
https://doi.org/10.3390/molecules29184295
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