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Open AccessArticle
Composite Hydrogels with Rapid Self-Healing, Stretchable, Moldable and Antibacterial Properties Based on PVA/ε-Poly-L-lysine/Hyaluronic Acid
by
Na Sun
Na Sun 1,
Xiangnan Liu
Xiangnan Liu 2,†,
Wenqi Lv
Wenqi Lv 2,†,
Chunlin Xu
Chunlin Xu 2,
Ailing Zhang
Ailing Zhang 3,* and
Panpan Sun
Panpan Sun 2,*
1
College of Pharmacy, Shandong Second Medical University, Weifang 261053, China
2
School of Bioscience and Technology, Shandong Second Medical University, Weifang 261053, China
3
College of Chemical Engineering and Environmental Chemistry, Weifang University, Weifang 261061, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2024, 29(19), 4666; https://doi.org/10.3390/molecules29194666 (registering DOI)
Submission received: 2 September 2024
/
Revised: 29 September 2024
/
Accepted: 30 September 2024
/
Published: 30 September 2024
Abstract
Self-healing, stretchable, and moldable hydrogels have a great potential application in tissue engineering and soft robotics. Despite great success in reported hydrogels, it is still a great challenge to construct the moldable hydrogels with an ultrafast self-healing performance. Herein, the composite hydrogels (PBLH) with ultrafast self-healing, stretchable, and moldable properties were successfully constructed by poly (vinyl alcohol) (PVA), borate (B), ε-poly-L-lysine (EPL), and hyaluronic acid (HA) based on an efficient one-pot method. Fourier transform infrared spectroscopy, X-ray diffraction, and rheological measurements confirmed the formation of a dynamic network among PVA, B, EPL, and HA through the cross-linking of dynamic borate bonds, electrostatic interaction, and hydrogen bonding. Having fabricated the dynamic network structure, the damage gap of the composite hydrogels can heal within 1 min, presenting an excellent self-healing ability. Simultaneously, the composite hydrogels can be molded into various shapes, and the length of the composite hydrogels can be stretched to 15 times their original length. In addition, the composite hydrogels exhibited an excellent antibacterial property against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Our results illustrated that the composite hydrogels not only retain the advantages of traditional hydrogels but also possess ultrafast self-healing, outstanding stretchable and antibacterial properties, presenting a prospective candidate for constructing biomedical materials.
Share and Cite
MDPI and ACS Style
Sun, N.; Liu, X.; Lv, W.; Xu, C.; Zhang, A.; Sun, P.
Composite Hydrogels with Rapid Self-Healing, Stretchable, Moldable and Antibacterial Properties Based on PVA/ε-Poly-L-lysine/Hyaluronic Acid. Molecules 2024, 29, 4666.
https://doi.org/10.3390/molecules29194666
AMA Style
Sun N, Liu X, Lv W, Xu C, Zhang A, Sun P.
Composite Hydrogels with Rapid Self-Healing, Stretchable, Moldable and Antibacterial Properties Based on PVA/ε-Poly-L-lysine/Hyaluronic Acid. Molecules. 2024; 29(19):4666.
https://doi.org/10.3390/molecules29194666
Chicago/Turabian Style
Sun, Na, Xiangnan Liu, Wenqi Lv, Chunlin Xu, Ailing Zhang, and Panpan Sun.
2024. "Composite Hydrogels with Rapid Self-Healing, Stretchable, Moldable and Antibacterial Properties Based on PVA/ε-Poly-L-lysine/Hyaluronic Acid" Molecules 29, no. 19: 4666.
https://doi.org/10.3390/molecules29194666
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