Chemistry of 2-(2′-Aminophenyl)benzothiazole Derivatives: Syntheses, Photophysical Properties and Applications

Pylova, Ekaterina K.; Sukhikh, Taisiya S.; Prieto, Alexis; Jaroschik, Florian; Konchenko, Sergey N.

doi:10.3390/molecules30081659

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Chemistry of 2-(2′-Aminophenyl)benzothiazole Derivatives: Syntheses, Photophysical Properties and Applications

by

Ekaterina K. Pylova

^1,2,3

,

Taisiya S. Sukhikh

¹

,

Alexis Prieto

³

,

Florian Jaroschik

^3,*

and

Sergey N. Konchenko

^1,*

¹

Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, 3 Lavrentiev Ave., 630090 Novosibirsk, Russia

²

Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia

³

ICGM, Univ Montpellier, CNRS, ENSCM, 34090 Montpellier, France

^*

Authors to whom correspondence should be addressed.

Molecules 2025, 30(8), 1659; https://doi.org/10.3390/molecules30081659

Submission received: 13 March 2025 / Revised: 1 April 2025 / Accepted: 3 April 2025 / Published: 8 April 2025

(This article belongs to the Special Issue Advances in Coordination Chemistry, 3rd Edition)

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Abstract

2-(2′-aminophenyl)benzothiazole is a readily tunable fluorescent core with widespread applications in coordination chemistry, sensing, light-emitting processes, medicinal chemistry, and catalysis. This review provides an overview of the synthetic methodologies to access 2-(2′-aminophenyl)benzothiazole and its organic derivatives, including various phosphorous and silane pincer ligands. The luminescent properties will be discussed, with a special focus on ESIPT and AIE processes. The coordination of transition metals and lanthanides is presented, as well as their influence on biological and light-emitting properties. 2-(2′-aminophenyl)benzothiazole derivatives have also been employed as sensors for a range of cations and anions due to their various binding modes, as well as for bioimaging purposes. Recently, the first application in photocatalysis has emerged, showing one of the many openings for these organic building blocks in the future.

Keywords: heterocycle; benzothiazole; metal–organic compounds; luminescence; ESIPT; sensors; bioimaging; photocatalysis

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MDPI and ACS Style

Pylova, E.K.; Sukhikh, T.S.; Prieto, A.; Jaroschik, F.; Konchenko, S.N. Chemistry of 2-(2′-Aminophenyl)benzothiazole Derivatives: Syntheses, Photophysical Properties and Applications. Molecules 2025, 30, 1659. https://doi.org/10.3390/molecules30081659

AMA Style

Pylova EK, Sukhikh TS, Prieto A, Jaroschik F, Konchenko SN. Chemistry of 2-(2′-Aminophenyl)benzothiazole Derivatives: Syntheses, Photophysical Properties and Applications. Molecules. 2025; 30(8):1659. https://doi.org/10.3390/molecules30081659

Chicago/Turabian Style

Pylova, Ekaterina K., Taisiya S. Sukhikh, Alexis Prieto, Florian Jaroschik, and Sergey N. Konchenko. 2025. "Chemistry of 2-(2′-Aminophenyl)benzothiazole Derivatives: Syntheses, Photophysical Properties and Applications" Molecules 30, no. 8: 1659. https://doi.org/10.3390/molecules30081659

APA Style

Pylova, E. K., Sukhikh, T. S., Prieto, A., Jaroschik, F., & Konchenko, S. N. (2025). Chemistry of 2-(2′-Aminophenyl)benzothiazole Derivatives: Syntheses, Photophysical Properties and Applications. Molecules, 30(8), 1659. https://doi.org/10.3390/molecules30081659

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Chemistry of 2-(2′-Aminophenyl)benzothiazole Derivatives: Syntheses, Photophysical Properties and Applications

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