Molecules, Volume 5, Issue 2

Physicochemical theoretical development has been dwarfed by the abundant experimental achievements in molecular recognition studies, including the template effects reported in this book [1-3].[...]

N-(2-Cyanophenyl)chloromethanimidoyl chloride (3) was prepared from 2-isothiocyanatobenzonitrile by the reaction with sulfuryl chloride or gaseous chlorine in an inert solvent. It was found that N-(2-cyanophenyl)chloromethanimidothioic chloride (2) a...

This is not only a book written by specialists for specialists, but also for everyone who wants to brush up on their knowledge on the rapidly and ever-growing field of combinatorial chemistry.[...]

A solution of ceric ammonium nitrate (37 mg, 0.067 mmol) in water was added dropwise to a vigorously stirred solution of naphthol 1 (13 mg, 0.036 mmol) [1] in acetonitrile (2.2 ml) at room temperature and stirred for 15 min.[...]

A mixture of alcohol 1 (121 mg, 0.23 mmol) [1], triethylamine (48 l, 0.34 mmol) and p-nitrobenzoyl chloride (51 mg, 0.28 mmol) in dichloromethane (2 ml) was stirred for 2 h. at 30ºC.[...]

A mixture of alcohol 1 (104 mg, 0.20 mmol) [1], triethylamine (41 l, 0.30 mmol) and 3,5-dinitrobenzoyl chloride (55 mg, 0.24 mmol) in dichloromethane (2 ml) was stirred for 2 h. at 30ºC.[...]

To a suspension of sodium hydride (5.9 mg, 60% in oil, 0.15 mmol) in tetrahydrofuran (0.34 ml) which contained a few drops of N,N-dimethylformamide, under nitrogen at 0°C, was added alcohol 1 (65 mg, 0.11 mmol) [1] in tetrahydrofuran (1.7 ml).[...]

To a solution of alcohol 1 (225 mg, 0.43 mmol) [1] in dry N,N-dimethylformamide (0.9 ml) at 0°C under an atmosphere of nitrogen was added imidazole (72 mg, 1.1 mmol) and tert-butyldimethylsilyl chloride (67 mg, 0.45 mmol).

Acetylation of hydantoins (imidazolidin-2,4-diones) and their 5-substituted derivatives normally occurs more readily in the 1-position [1].[...]

The title compound was synthesized by the reaction of N-benzyl-3-benzylamino-4-hydroxybutanamide with 3-pyridinecarboxaldehyde using the procedure described in [1].[...]

4-(5-Methyl-2-furfuryl)iden-2-furfurylaminobutanolide was prepared by the reaction of 4-(5-methyl- 2-furfuryl)iden-2-butenolide and furfurylamine according to a literature procedure [1].[...]

Ethyl 2-cyano-3,3-bis(methylthio)acrylate 1 [1] (3.255 g; 15.0 mmol) was dissolved in anhydrous ethanol (100 mL), n-butylamine (1.100 g; 15.0 mmol) was added and the solution was heated to reflux for 2 h in a flask equipped with a gas outlet to remov...

A new class of roof-shaped dibenzobarrelenemaleimide derivatives was prepared by the condensation of a bridged maleic anhydride with amines. A para-substituted bifunctional derivative was proven to be a 1:2 complex with acetone by an X-ray crystallog...

Addition of cyclopentadiene to bis-naphthoquinone (1) afforded predominantly the endo-endo [4+2] cycloadduct (2).

Different types of 3-substituted 4H-4-oxobenzopyrans were prepared by microwave irradiation as well as by a classical method. The beneficial effect of microwave irradiation on the aldol condensation of 3-formylchromones with 2-imino-1-methylimidazoli...

The 1,3-dipolar cycloaddition reaction of N-benzyl-C-(2-furyl)nitrones with electron-rich alkenes gives preferentially trans-substituted 3,5-disubstituted isoxazolidines (endo approach). These experimental results are in good qualitative agreement wi...

4-O-Methylcedrusin, a minor component in ‘sangre de drago’, has been synthesized using a strategy of successive protection and deprotection reactions under very mild conditions. The key step of this synthesis is a selective protection of a catechol g...

α-Alkoxynitrile 1 in the presence of tris(methylthio)methyllithium 2 at –78ºC gave the dimer 5 instead of the expected C₁-elongated product 3. The formation of compound 5 is explained in terms of anion formation and self-condensation, a variant of th...

A number of novel 3-bromo-4-methyl-7-methoxy-8-amino substituted coumarins and 2-substituted 7-bromo-6-methyl-8H-pyrano-benzimidazoles, benzoxazoles and/or benzoxazine-8-ones were synthesized for the purpose of pharmacological evaluation. Some repres...

The NaY zeolite catalysed hydrolysis of nitriles to primary amides is reported. It is found that aryl nitriles with strong electron-withdrawing substituents and cyanopyridines are readily hydrolysed in the water suspension, while aliphatic nitriles d...

The oxidation of a borane intermediate by PFC provides a convenient synthesis of 24-ketolanosteryl acetate.