Liquid Biopsy in Oral Cancer

Lousada-Fernandez, Fatima; Rapado-Gonzalez, Oscar; Lopez-Cedrun, Jose-Luis; Lopez-Lopez, Rafael; Muinelo-Romay, Laura; Suarez-Cunqueiro, Maria Mercedes

doi:10.3390/ijms19061704

Open AccessReview

Liquid Biopsy in Oral Cancer

by

Fatima Lousada-Fernandez

^1,†,

Oscar Rapado-Gonzalez

^1,2,†,

Jose-Luis Lopez-Cedrun

³,

Rafael Lopez-Lopez

⁴,

Laura Muinelo-Romay

^2,*

and

Maria Mercedes Suarez-Cunqueiro

^1,5,*

¹

Department of Surgery and Medical Surgical Specialties, Medicine and Dentistry School, Universidade de Santiago de Compostela, 15782 Spain

²

Liquid Biopsy Analysis Unit, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago de Compostela (IDIS), CIBERONC, 15706 Santiago de Compostela, Spain

³

Department of Oral and Maxillofacial Surgery, Complexo Hospitalario Universitario de A Coruña (SERGAS), 15006 La Coruña, Spain

⁴

Translational Medical Oncology, Health Research Institute of Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (SERGAS), ONCOMET, 15706 Santiago de Compostela, Spain

⁵

Oral Sciences, Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2018, 19(6), 1704; https://doi.org/10.3390/ijms19061704

Submission received: 20 April 2018 / Revised: 25 May 2018 / Accepted: 5 June 2018 / Published: 8 June 2018

(This article belongs to the Special Issue Oral Cancer—Diagnosis and Therapeutics)

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Abstract

Oral cancer is one of the most prevalent forms of cancer worldwide. Carcinogenesis is a complex process, in which heterogeneity plays an important role in the development and progression of the disease. This review provides an overview of the current biological and clinical significance of circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), and exosomes for diagnosis and prognosis of oral cancer. We highlight the importance of liquid biopsy—using blood and saliva—which represents a potential alternative to solid biopsy for diagnosis and prognosis. Moreover, liquid biomarkers allow for the real-time monitoring of tumour evolution and therapeutic responses, initiating the era of personalized medicine. However, in oral cancer, the impact of liquid biopsies in clinical settings is still limited, requiring further studies to discover the best scenario for its clinical use.

Keywords: oral cancer; circulating tumour cells (CTCs); circulating tumour DNA (ctDNA); exosomes; liquid biopsy

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MDPI and ACS Style

Lousada-Fernandez, F.; Rapado-Gonzalez, O.; Lopez-Cedrun, J.-L.; Lopez-Lopez, R.; Muinelo-Romay, L.; Suarez-Cunqueiro, M.M. Liquid Biopsy in Oral Cancer. Int. J. Mol. Sci. 2018, 19, 1704. https://doi.org/10.3390/ijms19061704

AMA Style

Lousada-Fernandez F, Rapado-Gonzalez O, Lopez-Cedrun J-L, Lopez-Lopez R, Muinelo-Romay L, Suarez-Cunqueiro MM. Liquid Biopsy in Oral Cancer. International Journal of Molecular Sciences. 2018; 19(6):1704. https://doi.org/10.3390/ijms19061704

Chicago/Turabian Style

Lousada-Fernandez, Fatima, Oscar Rapado-Gonzalez, Jose-Luis Lopez-Cedrun, Rafael Lopez-Lopez, Laura Muinelo-Romay, and Maria Mercedes Suarez-Cunqueiro. 2018. "Liquid Biopsy in Oral Cancer" International Journal of Molecular Sciences 19, no. 6: 1704. https://doi.org/10.3390/ijms19061704

APA Style

Lousada-Fernandez, F., Rapado-Gonzalez, O., Lopez-Cedrun, J.-L., Lopez-Lopez, R., Muinelo-Romay, L., & Suarez-Cunqueiro, M. M. (2018). Liquid Biopsy in Oral Cancer. International Journal of Molecular Sciences, 19(6), 1704. https://doi.org/10.3390/ijms19061704

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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