ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract

Inami, Akie; Kiyono, Hiroshi; Kurashima, Yosuke

doi:10.3390/ijms19082371

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ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract

by

Akie Inami

¹,

Hiroshi Kiyono

^1,2,3,4,5 and

Yosuke Kurashima

^{1,2,3,5,6,7,*}

¹

Department of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

²

International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan

³

Division of Gastroenterology, Department of Medicine, CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines, University of California, San Diego, CA 92093-0956, USA

⁴

Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan

⁵

Mucosal Immunology and Allergy Therapeutics, Institute for Global Prominent Research, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan

⁶

Department of Mucosal Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan

⁷

Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2018, 19(8), 2371; https://doi.org/10.3390/ijms19082371

Submission received: 10 July 2018 / Revised: 2 August 2018 / Accepted: 6 August 2018 / Published: 12 August 2018

(This article belongs to the Special Issue Purinergic Signalling in Cancer and Inflammation)

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Abstract

Extracellular nucleotides, such as adenosine triphosphate (ATP), are released from host cells including nerve termini, immune cells, injured or dead cells, and the commensal bacteria that reside in the gut lumen. Extracellular ATP interacts with the host through purinergic receptors, and promotes intercellular and bacteria-host communication to maintain the tissue homeostasis. However, the release of massive concentrations of ATP into extracellular compartments initiates acute and chronic inflammatory responses through the activation of immunocompetent cells (e.g., T cells, macrophages, and mast cells). In this review, we focus on the functions of ATP as a pathophysiologic mediator that is required for the induction and resolution of inflammation and inter-species communication.

Keywords: ATP; adenosine; inflammatory bowel disease (IBD); purinergic pathway; inter-species communication; commensal bacteria

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MDPI and ACS Style

Inami, A.; Kiyono, H.; Kurashima, Y. ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract. Int. J. Mol. Sci. 2018, 19, 2371. https://doi.org/10.3390/ijms19082371

AMA Style

Inami A, Kiyono H, Kurashima Y. ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract. International Journal of Molecular Sciences. 2018; 19(8):2371. https://doi.org/10.3390/ijms19082371

Chicago/Turabian Style

Inami, Akie, Hiroshi Kiyono, and Yosuke Kurashima. 2018. "ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract" International Journal of Molecular Sciences 19, no. 8: 2371. https://doi.org/10.3390/ijms19082371

APA Style

Inami, A., Kiyono, H., & Kurashima, Y. (2018). ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract. International Journal of Molecular Sciences, 19(8), 2371. https://doi.org/10.3390/ijms19082371

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract

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